[<sup>18</sup>F]FDG PET/CT Radiomics in Cervical Cancer: A Systematic Review
<b>Background/Objectives</b>: Cervical cancer is a significant global health concern, with high incidence and mortality rates, especially in less-developed regions. [<sup>18</sup>F]FDG PET/CT is now indicated at various stages of management, but its analysis is essentially ba...
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2024-12-01
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| author | Judicael Hotton Arnaud Beddok Abdenasser Moubtakir Dimitri Papathanassiou David Morland |
| author_facet | Judicael Hotton Arnaud Beddok Abdenasser Moubtakir Dimitri Papathanassiou David Morland |
| author_sort | Judicael Hotton |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Cervical cancer is a significant global health concern, with high incidence and mortality rates, especially in less-developed regions. [<sup>18</sup>F]FDG PET/CT is now indicated at various stages of management, but its analysis is essentially based on SUVmax, a measure of [<sup>18</sup>F]FDG uptake. Radiomics, by extracting a multitude of parameters, promises to improve the diagnostic and prognostic performance of the examination. However, studies remain heterogeneous, both in terms of patient numbers and methods, so a synthesis is needed. <b>Methods</b>: This systematic review was conducted following PRISMA-P guidelines and registered in PROSPERO (CRD42024584123). Eligible studies on PET/CT radiomics in cervical cancer were identified through PubMed and Scopus and assessed for quality using the Radiomics Quality Score (RQS v2.0), with data extraction focusing on study design, population characteristics, radiomic methods, and model performances. <b>Results</b>: The review identified 22 studies on radiomics in cervical cancer, 19 of which focused specifically on locally advanced cervical cancer (LACC) and assessed various clinical outcomes, such as survival, relapse, treatment response, and lymph node involvement prediction. They reported significant associations between prognostic indicators and radiomic features, indicating the potential of radiomics to improve the predictive accuracy for patient outcomes in LACC; however, the overall quality of the studies was relatively moderate, with a median RQS of 12/36. <b>Conclusions</b>: While radiomic analysis in cervical cancer presents promising opportunities for survival prediction and personalized care, further well-designed studies are essential to provide stronger evidence for its clinical utility. |
| format | Article |
| id | doaj-art-cb1c619180f443f49072fc67ffe7ba1d |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-cb1c619180f443f49072fc67ffe7ba1d2025-01-10T13:16:37ZengMDPI AGDiagnostics2075-44182024-12-011516510.3390/diagnostics15010065[<sup>18</sup>F]FDG PET/CT Radiomics in Cervical Cancer: A Systematic ReviewJudicael Hotton0Arnaud Beddok1Abdenasser Moubtakir2Dimitri Papathanassiou3David Morland4Department of Surgical Oncology, Institut Godinot, 51100 Reims, FranceCReSTIC, UR 3804, Université de Reims Champagne-Ardenne, 51687 Reims, FranceDepartment of Nuclear Medicine, Institut Godinot, 51100 Reims, FranceCReSTIC, UR 3804, Université de Reims Champagne-Ardenne, 51687 Reims, FranceCReSTIC, UR 3804, Université de Reims Champagne-Ardenne, 51687 Reims, France<b>Background/Objectives</b>: Cervical cancer is a significant global health concern, with high incidence and mortality rates, especially in less-developed regions. [<sup>18</sup>F]FDG PET/CT is now indicated at various stages of management, but its analysis is essentially based on SUVmax, a measure of [<sup>18</sup>F]FDG uptake. Radiomics, by extracting a multitude of parameters, promises to improve the diagnostic and prognostic performance of the examination. However, studies remain heterogeneous, both in terms of patient numbers and methods, so a synthesis is needed. <b>Methods</b>: This systematic review was conducted following PRISMA-P guidelines and registered in PROSPERO (CRD42024584123). Eligible studies on PET/CT radiomics in cervical cancer were identified through PubMed and Scopus and assessed for quality using the Radiomics Quality Score (RQS v2.0), with data extraction focusing on study design, population characteristics, radiomic methods, and model performances. <b>Results</b>: The review identified 22 studies on radiomics in cervical cancer, 19 of which focused specifically on locally advanced cervical cancer (LACC) and assessed various clinical outcomes, such as survival, relapse, treatment response, and lymph node involvement prediction. They reported significant associations between prognostic indicators and radiomic features, indicating the potential of radiomics to improve the predictive accuracy for patient outcomes in LACC; however, the overall quality of the studies was relatively moderate, with a median RQS of 12/36. <b>Conclusions</b>: While radiomic analysis in cervical cancer presents promising opportunities for survival prediction and personalized care, further well-designed studies are essential to provide stronger evidence for its clinical utility.https://www.mdpi.com/2075-4418/15/1/65radiomicssystematic reviewmethodological qualitylocally advanced cervical cancerPET/CT |
| spellingShingle | Judicael Hotton Arnaud Beddok Abdenasser Moubtakir Dimitri Papathanassiou David Morland [<sup>18</sup>F]FDG PET/CT Radiomics in Cervical Cancer: A Systematic Review Diagnostics radiomics systematic review methodological quality locally advanced cervical cancer PET/CT |
| title | [<sup>18</sup>F]FDG PET/CT Radiomics in Cervical Cancer: A Systematic Review |
| title_full | [<sup>18</sup>F]FDG PET/CT Radiomics in Cervical Cancer: A Systematic Review |
| title_fullStr | [<sup>18</sup>F]FDG PET/CT Radiomics in Cervical Cancer: A Systematic Review |
| title_full_unstemmed | [<sup>18</sup>F]FDG PET/CT Radiomics in Cervical Cancer: A Systematic Review |
| title_short | [<sup>18</sup>F]FDG PET/CT Radiomics in Cervical Cancer: A Systematic Review |
| title_sort | sup 18 sup f fdg pet ct radiomics in cervical cancer a systematic review |
| topic | radiomics systematic review methodological quality locally advanced cervical cancer PET/CT |
| url | https://www.mdpi.com/2075-4418/15/1/65 |
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