Heterogeneity of T cells regulates tumor immunity mediated by Helicobacter pylori infection in gastric cancer

Heterogeneity of T cells regulates tumor immunity mediated by Helicobacter pylori infection in gastric cancer

Abstract The impact of Helicobacter pylori (H. pylori) status on gastric cancer survival remains unclear. In this study, we conducted a prognostic analysis of 488 gastric cancer patients and performed single-cell RNA sequencing (scRNA-seq) on 18,717 T cells from six tumor samples with varying H. pyl...

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Main Authors: Zhisheng Wu, Xinya Wang, Shujing Shi, Deyuan Kong, Chuanli Ren, Lijun Bian, Yuanliang Gu, Fangmei An, Qiang Zhan, Caiwang Yan, Chupeng Hu, Yun Chen, Runqiu Jiang, Jinfei Chen
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Cancer
Subjects:
Gastric cancer
Helicobacter pylori
Immune microenvironment
Survival
Online Access:https://doi.org/10.1186/s12885-025-13957-9
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