Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format
This study addresses issues in developing spatially controlled magnetic fields for particle guidance, synthesizing biocompatible and chemically stable MNPs and enhancing their specificity to pathological cells through chemical modifications, developing personalized adjustments, and highlighting the...
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2024-12-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/14/24/2030 |
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| author | Tatiana Zimina Nikita Sitkov Ksenia Brusina Viacheslav Fedorov Natalia Mikhailova Dmitriy Testov Kamil Gareev Konstantin Samochernykh Stephanie Combs Maxim Shevtsov |
| author_facet | Tatiana Zimina Nikita Sitkov Ksenia Brusina Viacheslav Fedorov Natalia Mikhailova Dmitriy Testov Kamil Gareev Konstantin Samochernykh Stephanie Combs Maxim Shevtsov |
| author_sort | Tatiana Zimina |
| collection | DOAJ |
| description | This study addresses issues in developing spatially controlled magnetic fields for particle guidance, synthesizing biocompatible and chemically stable MNPs and enhancing their specificity to pathological cells through chemical modifications, developing personalized adjustments, and highlighting the potential of tumor-on-a-chip systems, which can simulate tissue environments and assess drug efficacy and dosage in a controlled setting. The research focused on two MNP types, uncoated magnetite nanoparticles (mMNPs) and carboxymethyl dextran coated superparamagnetic nanoparticles (CD-SPIONs), and evaluated their transport properties in microfluidic systems and porous media. The original uncoated mMNPs of bimodal size distribution and the narrow size distribution of the fractions (23 nm and 106 nm by radii) were demonstrated to agglomerate in magnetically driven microfluidic flow, forming a stable stationary web consisting of magnetic fibers within 30 min. CD-SPIONs were demonstrated to migrate in agar gel with the mean pore size equal to or slightly higher than the particle size. The migration velocity was inversely proportional to the size of particles. No compression of the gel was observed under the magnetic field gradient of 40 T/m. In the brain tissue, particles of sizes 220, 350, 820 nm were not penetrating the tissue, while the compression of tissue was observed. The particles of 95 nm size penetrated the tissue at the edge of the sample, and no compression was observed. For all particles, movement through capillary vessels was observed. |
| format | Article |
| id | doaj-art-cb111761219544d8a53dfd6c7fe3c795 |
| institution | DOAJ |
| issn | 2079-4991 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj-art-cb111761219544d8a53dfd6c7fe3c7952025-08-20T02:43:20ZengMDPI AGNanomaterials2079-49912024-12-011424203010.3390/nano14242030Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip FormatTatiana Zimina0Nikita Sitkov1Ksenia Brusina2Viacheslav Fedorov3Natalia Mikhailova4Dmitriy Testov5Kamil Gareev6Konstantin Samochernykh7Stephanie Combs8Maxim Shevtsov9Department of Micro and Nanoelectronics, St. Petersburg Electrotechnical University “LETI” (ETU “LETI”), Prof. Popova Str., 5, 197022 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, Akkuratova Str. 2, 197341 St. Petersburg, RussiaDepartment of Micro and Nanoelectronics, St. Petersburg Electrotechnical University “LETI” (ETU “LETI”), Prof. Popova Str., 5, 197022 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, Akkuratova Str. 2, 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, Akkuratova Str. 2, 197341 St. Petersburg, RussiaDepartment of Micro and Nanoelectronics, St. Petersburg Electrotechnical University “LETI” (ETU “LETI”), Prof. Popova Str., 5, 197022 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, Akkuratova Str. 2, 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, Akkuratova Str. 2, 197341 St. Petersburg, RussiaDepartment of Radiation Oncology, Technische Universität München (TUM), Klinikum Rechts der Isar, Ismaninger Str. 22, 81675 Munich, GermanyPersonalized Medicine Centre, Almazov National Medical Research Centre, Akkuratova Str. 2, 197341 St. Petersburg, RussiaThis study addresses issues in developing spatially controlled magnetic fields for particle guidance, synthesizing biocompatible and chemically stable MNPs and enhancing their specificity to pathological cells through chemical modifications, developing personalized adjustments, and highlighting the potential of tumor-on-a-chip systems, which can simulate tissue environments and assess drug efficacy and dosage in a controlled setting. The research focused on two MNP types, uncoated magnetite nanoparticles (mMNPs) and carboxymethyl dextran coated superparamagnetic nanoparticles (CD-SPIONs), and evaluated their transport properties in microfluidic systems and porous media. The original uncoated mMNPs of bimodal size distribution and the narrow size distribution of the fractions (23 nm and 106 nm by radii) were demonstrated to agglomerate in magnetically driven microfluidic flow, forming a stable stationary web consisting of magnetic fibers within 30 min. CD-SPIONs were demonstrated to migrate in agar gel with the mean pore size equal to or slightly higher than the particle size. The migration velocity was inversely proportional to the size of particles. No compression of the gel was observed under the magnetic field gradient of 40 T/m. In the brain tissue, particles of sizes 220, 350, 820 nm were not penetrating the tissue, while the compression of tissue was observed. The particles of 95 nm size penetrated the tissue at the edge of the sample, and no compression was observed. For all particles, movement through capillary vessels was observed.https://www.mdpi.com/2079-4991/14/24/2030tumormagnetic nanoparticlesmagnetically controlled transportmicrofluidic systemsorganic porous systemstissue engineering |
| spellingShingle | Tatiana Zimina Nikita Sitkov Ksenia Brusina Viacheslav Fedorov Natalia Mikhailova Dmitriy Testov Kamil Gareev Konstantin Samochernykh Stephanie Combs Maxim Shevtsov Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format Nanomaterials tumor magnetic nanoparticles magnetically controlled transport microfluidic systems organic porous systems tissue engineering |
| title | Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format |
| title_full | Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format |
| title_fullStr | Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format |
| title_full_unstemmed | Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format |
| title_short | Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format |
| title_sort | magnetically controlled transport of nanoparticles in solid tumor tissues and porous media using a tumor on a chip format |
| topic | tumor magnetic nanoparticles magnetically controlled transport microfluidic systems organic porous systems tissue engineering |
| url | https://www.mdpi.com/2079-4991/14/24/2030 |
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