Chitosan from sea urchin (Diadema setosum) spines for orthodontic miniscrews: Antibacterial effects against key oral pathogens

Objective: Peri-implantitis, exacerbated microbial growth characterized by progressive bone loss and soft-tissue inflammation, significantly contributes to miniscrew failure during orthodontic treatment. Using a natural antibacterial coating presents an innovative approach to combat bacterial coloni...

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Main Authors: Karima Qurnia Mansjur, Eka Erwansyah, Ardiansyah S Pawinru, Mansjur Nasir, Arni Irawaty Djais, Virgino Calvine Sumule, Nurnabilla Syfadewi Attaya, Dian Yosi Arinawaty, Islamy Rahma Hutami, Andi Dian Permana
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Oral Biology and Craniofacial Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S2212426825000557
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author Karima Qurnia Mansjur
Eka Erwansyah
Ardiansyah S Pawinru
Mansjur Nasir
Arni Irawaty Djais
Virgino Calvine Sumule
Nurnabilla Syfadewi Attaya
Dian Yosi Arinawaty
Islamy Rahma Hutami
Andi Dian Permana
author_facet Karima Qurnia Mansjur
Eka Erwansyah
Ardiansyah S Pawinru
Mansjur Nasir
Arni Irawaty Djais
Virgino Calvine Sumule
Nurnabilla Syfadewi Attaya
Dian Yosi Arinawaty
Islamy Rahma Hutami
Andi Dian Permana
author_sort Karima Qurnia Mansjur
collection DOAJ
description Objective: Peri-implantitis, exacerbated microbial growth characterized by progressive bone loss and soft-tissue inflammation, significantly contributes to miniscrew failure during orthodontic treatment. Using a natural antibacterial coating presents an innovative approach to combat bacterial colonization. Sea urchin (Diadema setosum) spines containing chitosan (CS) exhibit notable antibacterial properties and biocompatibility effects. This study investigates the antimicrobial potential of CS from sea urchin spines applied onto the surfaces of orthodontic miniscrews, aiming to mitigate the impact of peri-implantitis. Materials and methods: The surface functional groups, phase composition, and crystal structure of CS were investigated using traditional examination methods alongside energy-dispersive X-ray analysis. The antibacterial activity of CS was evaluated against three bacteria by the disk diffusion method, minimum bacterial concentration (MBC), and minimum inhibitory concentration (MIC). Stainless steel miniscrews were coated with CS, and the surface was characterized by scanning electron microscopy (SEM). Results and discussion: Sea urchin-derived chitosan demonstrated significant antibacterial effects against key oral pathogens associated with peri-implantitis, with minimum inhibitory concentrations (MICs) of 16 ppm against Fusobacterium nucleatum and 32 ppm for both Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. The minimum bactericidal concentrations (MBCs) were 4 ppm for A. actinomycetemcomitans and 16 ppm for both F. nucleatum and P. gingivalis, indicating its strong bactericidal potential. Scanning electron microscopy (SEM) revealed that sea urchin chitosan effectively adhered to the surface of orthodontic miniscrews, showcasing its potential as a functional antimicrobial coating. These results emphasize the capability of sea urchin chitosan to target key oral pathogens, offering a promising approach to enhance microbial resistance and improve outcomes in orthodontic treatments.
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publishDate 2025-05-01
publisher Elsevier
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series Journal of Oral Biology and Craniofacial Research
spelling doaj-art-cb0cc03ace3b47b48796c09741d729bc2025-08-20T02:31:05ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682025-05-0115346347110.1016/j.jobcr.2025.02.014Chitosan from sea urchin (Diadema setosum) spines for orthodontic miniscrews: Antibacterial effects against key oral pathogensKarima Qurnia Mansjur0Eka Erwansyah1Ardiansyah S Pawinru2Mansjur Nasir3Arni Irawaty Djais4Virgino Calvine Sumule5Nurnabilla Syfadewi Attaya6Dian Yosi Arinawaty7Islamy Rahma Hutami8Andi Dian Permana9Department of Orthodontics, Faculty of Dentistry, Hasanuddin University, Indonesia; Corresponding author. Perintis Kemerdekaan Street Km 10, Makassar, South Sulawesi, 90245, Indonesia.Department of Orthodontics, Faculty of Dentistry, Hasanuddin University, IndonesiaDepartment of Orthodontics, Faculty of Dentistry, Hasanuddin University, IndonesiaDepartment of Orthodontics, Faculty of Dentistry, Hasanuddin University, IndonesiaDepartment of Periodontology, Faculty of Dentistry, Hasanuddin University, IndonesiaDepartment of Orthodontics, Faculty of Dentistry, Hasanuddin University, IndonesiaDepartment of Orthodontics, Faculty of Dentistry, Hasanuddin University, IndonesiaDepartment of Oral Biology, Faculty of Dentistry, Universitas Muhammadiyah Yogyakarta, IndonesiaDepartment of Orthodontics, Faculty of Dentistry, Islamic University of Sultan Agung, IndonesiaFaculty of Pharmacy, Hasanuddin University, IndonesiaObjective: Peri-implantitis, exacerbated microbial growth characterized by progressive bone loss and soft-tissue inflammation, significantly contributes to miniscrew failure during orthodontic treatment. Using a natural antibacterial coating presents an innovative approach to combat bacterial colonization. Sea urchin (Diadema setosum) spines containing chitosan (CS) exhibit notable antibacterial properties and biocompatibility effects. This study investigates the antimicrobial potential of CS from sea urchin spines applied onto the surfaces of orthodontic miniscrews, aiming to mitigate the impact of peri-implantitis. Materials and methods: The surface functional groups, phase composition, and crystal structure of CS were investigated using traditional examination methods alongside energy-dispersive X-ray analysis. The antibacterial activity of CS was evaluated against three bacteria by the disk diffusion method, minimum bacterial concentration (MBC), and minimum inhibitory concentration (MIC). Stainless steel miniscrews were coated with CS, and the surface was characterized by scanning electron microscopy (SEM). Results and discussion: Sea urchin-derived chitosan demonstrated significant antibacterial effects against key oral pathogens associated with peri-implantitis, with minimum inhibitory concentrations (MICs) of 16 ppm against Fusobacterium nucleatum and 32 ppm for both Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. The minimum bactericidal concentrations (MBCs) were 4 ppm for A. actinomycetemcomitans and 16 ppm for both F. nucleatum and P. gingivalis, indicating its strong bactericidal potential. Scanning electron microscopy (SEM) revealed that sea urchin chitosan effectively adhered to the surface of orthodontic miniscrews, showcasing its potential as a functional antimicrobial coating. These results emphasize the capability of sea urchin chitosan to target key oral pathogens, offering a promising approach to enhance microbial resistance and improve outcomes in orthodontic treatments.http://www.sciencedirect.com/science/article/pii/S2212426825000557ChitosanSea urchinMiniscrew
spellingShingle Karima Qurnia Mansjur
Eka Erwansyah
Ardiansyah S Pawinru
Mansjur Nasir
Arni Irawaty Djais
Virgino Calvine Sumule
Nurnabilla Syfadewi Attaya
Dian Yosi Arinawaty
Islamy Rahma Hutami
Andi Dian Permana
Chitosan from sea urchin (Diadema setosum) spines for orthodontic miniscrews: Antibacterial effects against key oral pathogens
Journal of Oral Biology and Craniofacial Research
Chitosan
Sea urchin
Miniscrew
title Chitosan from sea urchin (Diadema setosum) spines for orthodontic miniscrews: Antibacterial effects against key oral pathogens
title_full Chitosan from sea urchin (Diadema setosum) spines for orthodontic miniscrews: Antibacterial effects against key oral pathogens
title_fullStr Chitosan from sea urchin (Diadema setosum) spines for orthodontic miniscrews: Antibacterial effects against key oral pathogens
title_full_unstemmed Chitosan from sea urchin (Diadema setosum) spines for orthodontic miniscrews: Antibacterial effects against key oral pathogens
title_short Chitosan from sea urchin (Diadema setosum) spines for orthodontic miniscrews: Antibacterial effects against key oral pathogens
title_sort chitosan from sea urchin diadema setosum spines for orthodontic miniscrews antibacterial effects against key oral pathogens
topic Chitosan
Sea urchin
Miniscrew
url http://www.sciencedirect.com/science/article/pii/S2212426825000557
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