Optic Neuritis: From Magnocellular to Cognitive Residual Dysfunction
Optic Neuritis (ON) has been associated to both parvocellular dysfunction and to an alteration of the magnocellular pathway. After objective visual field and acuity recovery, ON patients may complain about their vision suggesting a residual subclinical deficit. To better characterize visual abnormal...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.3233/BEN-120322 |
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| _version_ | 1832561246087413760 |
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| author | Anne-Claire Viret Céline Cavézian Olivier Coubard Vivien Vasseur Noa Raz Netta Levin Catherine Vignal Olivier Gout Sylvie Chokron |
| author_facet | Anne-Claire Viret Céline Cavézian Olivier Coubard Vivien Vasseur Noa Raz Netta Levin Catherine Vignal Olivier Gout Sylvie Chokron |
| author_sort | Anne-Claire Viret |
| collection | DOAJ |
| description | Optic Neuritis (ON) has been associated to both parvocellular dysfunction and to an alteration of the magnocellular pathway. After objective visual field and acuity recovery, ON patients may complain about their vision suggesting a residual subclinical deficit. To better characterize visual abnormalities, 8 patients recovering from a first ON episode as well as 16 healthy controls performed a simple detection task and a more complex categorization task of images presented in low spatial frequencies (to target the magnocellular system) or in high spatial frequencies (to target the parvocellular system) or of non-filtered images. When completing the tasks with their (previously) pathologic eye, optic neuritis patients showed lower accuracy compared to controls or to their healthy eye for low spatial frequency images only. Conjointly, the longest reaction times were observed with the previously pathologic eye regardless the type of images and to a greater extent in the categorization task than in the detection task. Such data suggest two distinct, although associated, types of residual dysfunction in ON: a magnocellular pathway alteration and a more general (magno and parvocellular) visual dysfunction that could implicate the cognitive levels of visual processing. |
| format | Article |
| id | doaj-art-cb0c48dbfc1a4b7c86b4661073899e88 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-cb0c48dbfc1a4b7c86b4661073899e882025-02-03T01:25:42ZengWileyBehavioural Neurology0953-41801875-85842013-01-0127327728310.3233/BEN-120322Optic Neuritis: From Magnocellular to Cognitive Residual DysfunctionAnne-Claire Viret0Céline Cavézian1Olivier Coubard2Vivien Vasseur3Noa Raz4Netta Levin5Catherine Vignal6Olivier Gout7Sylvie Chokron8Unité Fonctionnelle Vision et Cognition, Fondation Ophtalmologique Rothschild, Paris, FranceLaboratoire Vision, Action, Cognition—EAU 01, Université Paris Descartes—Sorbonne Paris Cité, Boulogne-Billancourt, France, FranceService d’Ophtalmologie, Fondation Ophtalmologique Rothschild, Paris, FranceThe Neuropsychological Laboratory, CNS-Fed, Paris, FranceDepartment of Neurology, Hadassah Hebrew-University Hospital, Jerusalem, IsraelDepartment of Neurology, Hadassah Hebrew-University Hospital, Jerusalem, IsraelThe Neuropsychological Laboratory, CNS-Fed, Paris, FranceService de Neurologie, Fondation Ophtalmologique Rothschild, Paris, FranceUnité Fonctionnelle Vision et Cognition, Fondation Ophtalmologique Rothschild, Paris, FranceOptic Neuritis (ON) has been associated to both parvocellular dysfunction and to an alteration of the magnocellular pathway. After objective visual field and acuity recovery, ON patients may complain about their vision suggesting a residual subclinical deficit. To better characterize visual abnormalities, 8 patients recovering from a first ON episode as well as 16 healthy controls performed a simple detection task and a more complex categorization task of images presented in low spatial frequencies (to target the magnocellular system) or in high spatial frequencies (to target the parvocellular system) or of non-filtered images. When completing the tasks with their (previously) pathologic eye, optic neuritis patients showed lower accuracy compared to controls or to their healthy eye for low spatial frequency images only. Conjointly, the longest reaction times were observed with the previously pathologic eye regardless the type of images and to a greater extent in the categorization task than in the detection task. Such data suggest two distinct, although associated, types of residual dysfunction in ON: a magnocellular pathway alteration and a more general (magno and parvocellular) visual dysfunction that could implicate the cognitive levels of visual processing.http://dx.doi.org/10.3233/BEN-120322 |
| spellingShingle | Anne-Claire Viret Céline Cavézian Olivier Coubard Vivien Vasseur Noa Raz Netta Levin Catherine Vignal Olivier Gout Sylvie Chokron Optic Neuritis: From Magnocellular to Cognitive Residual Dysfunction Behavioural Neurology |
| title | Optic Neuritis: From Magnocellular to Cognitive Residual Dysfunction |
| title_full | Optic Neuritis: From Magnocellular to Cognitive Residual Dysfunction |
| title_fullStr | Optic Neuritis: From Magnocellular to Cognitive Residual Dysfunction |
| title_full_unstemmed | Optic Neuritis: From Magnocellular to Cognitive Residual Dysfunction |
| title_short | Optic Neuritis: From Magnocellular to Cognitive Residual Dysfunction |
| title_sort | optic neuritis from magnocellular to cognitive residual dysfunction |
| url | http://dx.doi.org/10.3233/BEN-120322 |
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