Quiescence Multiverse
Cellular quiescence is operationally defined as a temporary and reversible cessation of proliferation. This state encompasses a wide range of physiological situations since most cells, from microbes to cells composing complex tissues, spend most of their lives non-dividing, waiting for signals to re...
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MDPI AG
2025-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/7/960 |
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| author | Damien Laporte Isabelle Sagot |
| author_facet | Damien Laporte Isabelle Sagot |
| author_sort | Damien Laporte |
| collection | DOAJ |
| description | Cellular quiescence is operationally defined as a temporary and reversible cessation of proliferation. This state encompasses a wide range of physiological situations since most cells, from microbes to cells composing complex tissues, spend most of their lives non-dividing, waiting for signals to reproliferate. As such, individual quiescent cells must withstand the effects of time not only to survive but also to maintain their ability to divide. These capacities are shaped by a combination of deterministic factors relying on cell history and cumulative stochastic events linked to the environment but also to time. In addition, with time, quiescence deepens, the quiescence exit process being extended. Yet, this deepening is not necessarily sensed evenly by each individual quiescent cell, and some cells exit quiescence faster than others. Hence, time generates heterogeneity within quiescent cell populations, heterogeneity that, in turn, increases cell population resilience and robustness to time. In this review, we discuss some of the loops that link quiescence and time. |
| format | Article |
| id | doaj-art-cb0c056c8b0841fcbe1ffc2173e74370 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-cb0c056c8b0841fcbe1ffc2173e743702025-08-20T03:58:27ZengMDPI AGBiomolecules2218-273X2025-07-0115796010.3390/biom15070960Quiescence MultiverseDamien Laporte0Isabelle Sagot1CNRS, Institut de Biochimie et Génétique Cellulaires, UMR5095, Université de Bordeaux, 33077 Bordeaux, FranceCNRS, Institut de Biochimie et Génétique Cellulaires, UMR5095, Université de Bordeaux, 33077 Bordeaux, FranceCellular quiescence is operationally defined as a temporary and reversible cessation of proliferation. This state encompasses a wide range of physiological situations since most cells, from microbes to cells composing complex tissues, spend most of their lives non-dividing, waiting for signals to reproliferate. As such, individual quiescent cells must withstand the effects of time not only to survive but also to maintain their ability to divide. These capacities are shaped by a combination of deterministic factors relying on cell history and cumulative stochastic events linked to the environment but also to time. In addition, with time, quiescence deepens, the quiescence exit process being extended. Yet, this deepening is not necessarily sensed evenly by each individual quiescent cell, and some cells exit quiescence faster than others. Hence, time generates heterogeneity within quiescent cell populations, heterogeneity that, in turn, increases cell population resilience and robustness to time. In this review, we discuss some of the loops that link quiescence and time.https://www.mdpi.com/2218-273X/15/7/960ageingquiescencestem cells |
| spellingShingle | Damien Laporte Isabelle Sagot Quiescence Multiverse Biomolecules ageing quiescence stem cells |
| title | Quiescence Multiverse |
| title_full | Quiescence Multiverse |
| title_fullStr | Quiescence Multiverse |
| title_full_unstemmed | Quiescence Multiverse |
| title_short | Quiescence Multiverse |
| title_sort | quiescence multiverse |
| topic | ageing quiescence stem cells |
| url | https://www.mdpi.com/2218-273X/15/7/960 |
| work_keys_str_mv | AT damienlaporte quiescencemultiverse AT isabellesagot quiescencemultiverse |