Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies
Abstract Background One of the most serious and potentially hazardous diseases that trouble the globe today is cancer. Among various cancer treatment options, chemotherapy is currently one of the most efficient ways to remove cancer. Heterocycles play a pivotal role in development of efficient antic...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-06-01
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| Series: | Future Journal of Pharmaceutical Sciences |
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| Online Access: | https://doi.org/10.1186/s43094-025-00821-7 |
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| author | Bhupender Nehra Manoj Kumar Viney Chawla Pooja A. Chawla |
| author_facet | Bhupender Nehra Manoj Kumar Viney Chawla Pooja A. Chawla |
| author_sort | Bhupender Nehra |
| collection | DOAJ |
| description | Abstract Background One of the most serious and potentially hazardous diseases that trouble the globe today is cancer. Among various cancer treatment options, chemotherapy is currently one of the most efficient ways to remove cancer. Heterocycles play a pivotal role in development of efficient anticancer agents. Pyrazole scaffolds have made a substantial contribution to the development of anticancer medications through encouraging ability to combat cancer of synthetic derivatives. Aim and objectives There is a discussion of the synthetic developments of analogues with pyrazole motifs and the related anticancer potential that has been demonstrated by in vitro, in vivo, and in silico methods. Numerous research publications have documented a complete correlation between the design and synthesis of pyrazole-based anticancer compounds. With the following goals in mind, this research aims to explain significant recent advancements in the synthetic and medicinal chemistry of pyrazole-based compounds over the past four to 5 years: (1) highlighting new findings on the anticancer effects of pyrazole derivatives; (2) reviewing the most recent developments in pyrazole derivative synthesis and their biological importance in the fight against cancer; and (3) talking about structure activity relationship (SAR) studies of pyrazole-based compounds to treat various types of cancer. Short conclusion There are numerous applications of pyrazole ranging from both synthetic and natural derivatives with potent anticancer effects. Safer chemotherapeutic lead molecules with greater potency and lower cytotoxicity can prevent adverse effects on ordinary cells caused due to nonselective inhibitory action against the target cell or receptor and also diminish the growth of drug resistance. This review provides insights into the synthesis and design of compounds based on pyrazoles that show interest as anticancer agents. Graphical abstract |
| format | Article |
| id | doaj-art-cb0ba67b06874a85a1a8d4139f299c2d |
| institution | Kabale University |
| issn | 2314-7253 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj-art-cb0ba67b06874a85a1a8d4139f299c2d2025-08-20T03:47:24ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532025-06-0111114910.1186/s43094-025-00821-7Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studiesBhupender Nehra0Manoj Kumar1Viney Chawla2Pooja A. Chawla3Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and TechnologyDepartment of Pharmaceutical Sciences, Guru Jambheshwar University of Science and TechnologyUniversity Institute of Pharmaceutical Sciences and Research, BFUHSUniversity Institute of Pharmaceutical Sciences and Research, BFUHSAbstract Background One of the most serious and potentially hazardous diseases that trouble the globe today is cancer. Among various cancer treatment options, chemotherapy is currently one of the most efficient ways to remove cancer. Heterocycles play a pivotal role in development of efficient anticancer agents. Pyrazole scaffolds have made a substantial contribution to the development of anticancer medications through encouraging ability to combat cancer of synthetic derivatives. Aim and objectives There is a discussion of the synthetic developments of analogues with pyrazole motifs and the related anticancer potential that has been demonstrated by in vitro, in vivo, and in silico methods. Numerous research publications have documented a complete correlation between the design and synthesis of pyrazole-based anticancer compounds. With the following goals in mind, this research aims to explain significant recent advancements in the synthetic and medicinal chemistry of pyrazole-based compounds over the past four to 5 years: (1) highlighting new findings on the anticancer effects of pyrazole derivatives; (2) reviewing the most recent developments in pyrazole derivative synthesis and their biological importance in the fight against cancer; and (3) talking about structure activity relationship (SAR) studies of pyrazole-based compounds to treat various types of cancer. Short conclusion There are numerous applications of pyrazole ranging from both synthetic and natural derivatives with potent anticancer effects. Safer chemotherapeutic lead molecules with greater potency and lower cytotoxicity can prevent adverse effects on ordinary cells caused due to nonselective inhibitory action against the target cell or receptor and also diminish the growth of drug resistance. This review provides insights into the synthesis and design of compounds based on pyrazoles that show interest as anticancer agents. Graphical abstracthttps://doi.org/10.1186/s43094-025-00821-7CancerPyrazoleSyntheticTarget-basedDockingStructure activity relationship |
| spellingShingle | Bhupender Nehra Manoj Kumar Viney Chawla Pooja A. Chawla Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies Future Journal of Pharmaceutical Sciences Cancer Pyrazole Synthetic Target-based Docking Structure activity relationship |
| title | Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies |
| title_full | Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies |
| title_fullStr | Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies |
| title_full_unstemmed | Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies |
| title_short | Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies |
| title_sort | current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with sar studies |
| topic | Cancer Pyrazole Synthetic Target-based Docking Structure activity relationship |
| url | https://doi.org/10.1186/s43094-025-00821-7 |
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