Long Noncoding RNA Regulation of Pluripotency
Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers. As such, human Embryonic Stem Cells (hESCs) and human induced Pluripotent Stem Cells (hiPSCs) provide...
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| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/1797692 |
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| author | Alessandro Rosa Monica Ballarino |
| author_facet | Alessandro Rosa Monica Ballarino |
| author_sort | Alessandro Rosa |
| collection | DOAJ |
| description | Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers. As such, human Embryonic Stem Cells (hESCs) and human induced Pluripotent Stem Cells (hiPSCs) provide a unique opportunity for studying the earliest steps of human embryogenesis and, at the same time, are of great therapeutic interest. The molecular mechanisms underlying pluripotency represent a major field of research. Recent evidence suggests that a complex network of transcription factors, chromatin regulators, and noncoding RNAs exist in pluripotent cells to regulate the balance between self-renewal and multilineage differentiation. Regulatory noncoding RNAs come in two flavors: short and long. The first class includes microRNAs (miRNAs), which are involved in the posttranscriptional regulation of cell cycle and differentiation in PSCs. Instead, long noncoding RNAs (lncRNAs) represent a heterogeneous group of long transcripts that regulate gene expression at transcriptional and posttranscriptional levels. In this review, we focus on the role played by lncRNAs in the maintenance of pluripotency, emphasizing the interplay between lncRNAs and other pivotal regulators in PSCs. |
| format | Article |
| id | doaj-art-cb0a99f2be2145468af040c32bdc44aa |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-cb0a99f2be2145468af040c32bdc44aa2025-02-03T05:46:35ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/17976921797692Long Noncoding RNA Regulation of PluripotencyAlessandro Rosa0Monica Ballarino1Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, 00185 Rome, ItalyPluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers. As such, human Embryonic Stem Cells (hESCs) and human induced Pluripotent Stem Cells (hiPSCs) provide a unique opportunity for studying the earliest steps of human embryogenesis and, at the same time, are of great therapeutic interest. The molecular mechanisms underlying pluripotency represent a major field of research. Recent evidence suggests that a complex network of transcription factors, chromatin regulators, and noncoding RNAs exist in pluripotent cells to regulate the balance between self-renewal and multilineage differentiation. Regulatory noncoding RNAs come in two flavors: short and long. The first class includes microRNAs (miRNAs), which are involved in the posttranscriptional regulation of cell cycle and differentiation in PSCs. Instead, long noncoding RNAs (lncRNAs) represent a heterogeneous group of long transcripts that regulate gene expression at transcriptional and posttranscriptional levels. In this review, we focus on the role played by lncRNAs in the maintenance of pluripotency, emphasizing the interplay between lncRNAs and other pivotal regulators in PSCs.http://dx.doi.org/10.1155/2016/1797692 |
| spellingShingle | Alessandro Rosa Monica Ballarino Long Noncoding RNA Regulation of Pluripotency Stem Cells International |
| title | Long Noncoding RNA Regulation of Pluripotency |
| title_full | Long Noncoding RNA Regulation of Pluripotency |
| title_fullStr | Long Noncoding RNA Regulation of Pluripotency |
| title_full_unstemmed | Long Noncoding RNA Regulation of Pluripotency |
| title_short | Long Noncoding RNA Regulation of Pluripotency |
| title_sort | long noncoding rna regulation of pluripotency |
| url | http://dx.doi.org/10.1155/2016/1797692 |
| work_keys_str_mv | AT alessandrorosa longnoncodingrnaregulationofpluripotency AT monicaballarino longnoncodingrnaregulationofpluripotency |