Impact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims database
Abstract Cardiovascular disease (CVD) is a global health concern; however, its association with the posterior occlusal contact remains unexplored. This study investigated the association between posterior occlusal contact and CVD risk in a large Japanese cohort and examined whether the loss of poste...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-01846-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849726259805814784 |
|---|---|
| author | Takashi Miyano Yudai Tamada Taro Kusama Ken Osaka Kenji Takeuchi |
| author_facet | Takashi Miyano Yudai Tamada Taro Kusama Ken Osaka Kenji Takeuchi |
| author_sort | Takashi Miyano |
| collection | DOAJ |
| description | Abstract Cardiovascular disease (CVD) is a global health concern; however, its association with the posterior occlusal contact remains unexplored. This study investigated the association between posterior occlusal contact and CVD risk in a large Japanese cohort and examined whether the loss of posterior occlusal contact in individuals with at least 20 teeth was a distinct CVD risk factor. Using Japanese health insurance claims data from 1,209,997 adults aged ≥ 40 years without prior CVD history (April 2016–March 2022), participants were categorized using the Eichner classification to assess posterior occlusal contact. Over an average follow-up period of 36.2 months, 51,471 participants developed CVD. Compared with individuals with full occlusal contact (Eichner A), those with reduced contact (Eichner B and C) demonstrated significantly higher CVD risks, with hazard ratios of 1.25 (95% confidence interval [CI]: 1.19–1.32) and 1.31 (95% CI: 1.17–1.46), respectively. In a subgroup analysis of participants with ≥ 20 teeth, reduced occlusal contact from Eichner A2 to B2 was associated with an increased risk of CVD, especially in those aged 40–59 years. These findings suggest that reduced posterior occlusal contact may contribute to increased CVD risk, emphasizing the importance of preserving natural occlusal support for CVD prevention. |
| format | Article |
| id | doaj-art-cb0a3f57dd144e3e9e434103b034f0d5 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-cb0a3f57dd144e3e9e434103b034f0d52025-08-20T03:10:13ZengNature PortfolioScientific Reports2045-23222025-05-0115111210.1038/s41598-025-01846-xImpact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims databaseTakashi Miyano0Yudai Tamada1Taro Kusama2Ken Osaka3Kenji Takeuchi4Department of Medical and Robotic Engineering Design, Tokyo University of ScienceDepartment of International and Community Oral Health, Tohoku University Graduate School of DentistryDepartment of International and Community Oral Health, Tohoku University Graduate School of DentistryDepartment of International and Community Oral Health, Tohoku University Graduate School of DentistryDepartment of International and Community Oral Health, Tohoku University Graduate School of DentistryAbstract Cardiovascular disease (CVD) is a global health concern; however, its association with the posterior occlusal contact remains unexplored. This study investigated the association between posterior occlusal contact and CVD risk in a large Japanese cohort and examined whether the loss of posterior occlusal contact in individuals with at least 20 teeth was a distinct CVD risk factor. Using Japanese health insurance claims data from 1,209,997 adults aged ≥ 40 years without prior CVD history (April 2016–March 2022), participants were categorized using the Eichner classification to assess posterior occlusal contact. Over an average follow-up period of 36.2 months, 51,471 participants developed CVD. Compared with individuals with full occlusal contact (Eichner A), those with reduced contact (Eichner B and C) demonstrated significantly higher CVD risks, with hazard ratios of 1.25 (95% confidence interval [CI]: 1.19–1.32) and 1.31 (95% CI: 1.17–1.46), respectively. In a subgroup analysis of participants with ≥ 20 teeth, reduced occlusal contact from Eichner A2 to B2 was associated with an increased risk of CVD, especially in those aged 40–59 years. These findings suggest that reduced posterior occlusal contact may contribute to increased CVD risk, emphasizing the importance of preserving natural occlusal support for CVD prevention.https://doi.org/10.1038/s41598-025-01846-xCardiovascular diseaseOcclusal contactsEichner classificationTooth number, healthcare administrative claims |
| spellingShingle | Takashi Miyano Yudai Tamada Taro Kusama Ken Osaka Kenji Takeuchi Impact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims database Scientific Reports Cardiovascular disease Occlusal contacts Eichner classification Tooth number, healthcare administrative claims |
| title | Impact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims database |
| title_full | Impact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims database |
| title_fullStr | Impact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims database |
| title_full_unstemmed | Impact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims database |
| title_short | Impact of posterior occlusal contact loss on cardiovascular disease using a Japanese claims database |
| title_sort | impact of posterior occlusal contact loss on cardiovascular disease using a japanese claims database |
| topic | Cardiovascular disease Occlusal contacts Eichner classification Tooth number, healthcare administrative claims |
| url | https://doi.org/10.1038/s41598-025-01846-x |
| work_keys_str_mv | AT takashimiyano impactofposteriorocclusalcontactlossoncardiovasculardiseaseusingajapaneseclaimsdatabase AT yudaitamada impactofposteriorocclusalcontactlossoncardiovasculardiseaseusingajapaneseclaimsdatabase AT tarokusama impactofposteriorocclusalcontactlossoncardiovasculardiseaseusingajapaneseclaimsdatabase AT kenosaka impactofposteriorocclusalcontactlossoncardiovasculardiseaseusingajapaneseclaimsdatabase AT kenjitakeuchi impactofposteriorocclusalcontactlossoncardiovasculardiseaseusingajapaneseclaimsdatabase |