Sympathetic nerve block as an add-on therapy for intervention and prevention of cerebral vasospasm after subarachnoid hemorrhage
Cerebral vasospasm is a major complication after subarachnoid hemorrhage (SAH) and is an important factor leading to disability and mortality in patients. Cerebral vasospasm involves cerebral artery stenosis and leads to delayed cerebral ischemia, further exacerbating brain damage. The pathophysiolo...
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| Format: | Article |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1571550/full |
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| author | Zhaoquan Wang Jianqiang Li |
| author_facet | Zhaoquan Wang Jianqiang Li |
| author_sort | Zhaoquan Wang |
| collection | DOAJ |
| description | Cerebral vasospasm is a major complication after subarachnoid hemorrhage (SAH) and is an important factor leading to disability and mortality in patients. Cerebral vasospasm involves cerebral artery stenosis and leads to delayed cerebral ischemia, further exacerbating brain damage. The pathophysiology of cerebral vasospasm is multifactorial, involving a complex interaction between fragmented red blood cell metabolism, endothelial dysfunction, and hyperresponsive contraction of smooth muscle cells. Recent studies have highlighted the important role of the sympathetic nervous system (SNS) in mediating and exacerbating cerebral vasospasm. Sympathetic activation affects vascular tone and contributes to the development of vasospasm after SAH. Stellate ganglion block (SGB) has been reported to have a protective effect in patients at risk for vasospasm after SAH due to reduced sympathetic activity. This review aims to explore the current understanding of the relationship between sympathetic activity and cerebral vasospasm, investigate the molecular mechanisms involved, clinical implications, and potential therapeutic strategies targeting sympathetic modulation. |
| format | Article |
| id | doaj-art-caf41a2a1a1f44f5a4f19372a539a5e7 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-caf41a2a1a1f44f5a4f19372a539a5e72025-08-20T03:26:16ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-06-011610.3389/fneur.2025.15715501571550Sympathetic nerve block as an add-on therapy for intervention and prevention of cerebral vasospasm after subarachnoid hemorrhageZhaoquan WangJianqiang LiCerebral vasospasm is a major complication after subarachnoid hemorrhage (SAH) and is an important factor leading to disability and mortality in patients. Cerebral vasospasm involves cerebral artery stenosis and leads to delayed cerebral ischemia, further exacerbating brain damage. The pathophysiology of cerebral vasospasm is multifactorial, involving a complex interaction between fragmented red blood cell metabolism, endothelial dysfunction, and hyperresponsive contraction of smooth muscle cells. Recent studies have highlighted the important role of the sympathetic nervous system (SNS) in mediating and exacerbating cerebral vasospasm. Sympathetic activation affects vascular tone and contributes to the development of vasospasm after SAH. Stellate ganglion block (SGB) has been reported to have a protective effect in patients at risk for vasospasm after SAH due to reduced sympathetic activity. This review aims to explore the current understanding of the relationship between sympathetic activity and cerebral vasospasm, investigate the molecular mechanisms involved, clinical implications, and potential therapeutic strategies targeting sympathetic modulation.https://www.frontiersin.org/articles/10.3389/fneur.2025.1571550/fullcerebral vasospasmsubarachnoid hemorrhagesympathetic nervous systemstellate ganglion blockROS |
| spellingShingle | Zhaoquan Wang Jianqiang Li Sympathetic nerve block as an add-on therapy for intervention and prevention of cerebral vasospasm after subarachnoid hemorrhage Frontiers in Neurology cerebral vasospasm subarachnoid hemorrhage sympathetic nervous system stellate ganglion block ROS |
| title | Sympathetic nerve block as an add-on therapy for intervention and prevention of cerebral vasospasm after subarachnoid hemorrhage |
| title_full | Sympathetic nerve block as an add-on therapy for intervention and prevention of cerebral vasospasm after subarachnoid hemorrhage |
| title_fullStr | Sympathetic nerve block as an add-on therapy for intervention and prevention of cerebral vasospasm after subarachnoid hemorrhage |
| title_full_unstemmed | Sympathetic nerve block as an add-on therapy for intervention and prevention of cerebral vasospasm after subarachnoid hemorrhage |
| title_short | Sympathetic nerve block as an add-on therapy for intervention and prevention of cerebral vasospasm after subarachnoid hemorrhage |
| title_sort | sympathetic nerve block as an add on therapy for intervention and prevention of cerebral vasospasm after subarachnoid hemorrhage |
| topic | cerebral vasospasm subarachnoid hemorrhage sympathetic nervous system stellate ganglion block ROS |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1571550/full |
| work_keys_str_mv | AT zhaoquanwang sympatheticnerveblockasanaddontherapyforinterventionandpreventionofcerebralvasospasmaftersubarachnoidhemorrhage AT jianqiangli sympatheticnerveblockasanaddontherapyforinterventionandpreventionofcerebralvasospasmaftersubarachnoidhemorrhage |