Correlation between clinical severity and quality of life in moderate to severe psoriasis patients: Real-world evidence
Background/Aim. Psoriasis is a chronic multisystem, inflammatory, and immune-mediated dermatological disease of a relapsing nature. Not only does it affect objective parameters such as skin and joints, with different intensity involvement and with changes and the degree of changes, but it also signi...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2023-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300050M.pdf |
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| author | Milidrag Ardea Safiye Teodora Gutić Medo Zlatanović Milena Radević Svetlana Ravić-Nikolić Ana |
| author_facet | Milidrag Ardea Safiye Teodora Gutić Medo Zlatanović Milena Radević Svetlana Ravić-Nikolić Ana |
| author_sort | Milidrag Ardea |
| collection | DOAJ |
| description | Background/Aim. Psoriasis is a chronic multisystem, inflammatory, and immune-mediated dermatological disease of a relapsing nature. Not only does it affect objective parameters such as skin and joints, with different intensity involvement and with changes and the degree of changes, but it also significantly affects the health-related quality of life (QoL). The aim of the study was to determine the clinical severity and QoL of patients with moderate to severe psoriasis and examine the association between those parameters before and after the treatment. Methods. This cross-sectional study included 183 patients diagnosed with moderate to severe psoriasis. The severity of the clinical picture was determined by calculating the Psoriasis Area and Severity Index (PASI) by a dermatologist, while the QoL was assessed using the Dermatology Life Quality Index (DLQI) questionnaire and psoriasis-related stress by the Psoriasis Life Stress Inventory (PLSI). Disease severity and QoL were measured at the baseline visit and after the 16th week of therapy. Results. The average PASI score at the beginning of therapy was 23.1 ± 6 .5, while after 16 weeks, this value was 4.36 ± 4.86. The DLQI score was 20.8 ± 5.0 at the start of therapy and 6.20 ± 6 .16 after 16 weeks, while the PLSI score was 35.37 ± 8.84 initially and 12.75 ± 12.82 after 16 weeks of therapy. A strong correlation was found between PASI and PLSI scores (r = 0.702, р < 0.001) in the 16th week of therapy, while the correlation between DLQI and PASI scores was moderate (r = 0.683, р < 0.001). No significant differences between PASI and DLQI scores were found (r = 0.080, р = 0.284) nor between PASI and PLSI scores (r = 0.109, р = 0.140) at baseline. Conclusion. Patients with severe psoriasis experience a significant reduction in their QoL, accompanied by a high level of psychosocial stress. Observed improvements in QoL have shown a moderate correlation, while lower levels of psychosocial stress have strongly correlated with the severity of the clinical presentation, which may indicate a complex interaction between psychological factors and physical health in patients with psoriasis. |
| format | Article |
| id | doaj-art-caf3d641ce5d469982a50163288e1a41 |
| institution | DOAJ |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-caf3d641ce5d469982a50163288e1a412025-08-20T03:24:04ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202023-01-01801192793210.2298/VSP230401050M0042-84502300050MCorrelation between clinical severity and quality of life in moderate to severe psoriasis patients: Real-world evidenceMilidrag Ardea0https://orcid.org/0000-0001-6766-9196Safiye Teodora1Gutić Medo2Zlatanović Milena3Radević Svetlana4https://orcid.org/0000-0001-7329-1310Ravić-Nikolić Ana5https://orcid.org/0000-0002-9402-0832University of Kragujevac, Faculty of Medical Sciences, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia + Public Health Institution Health Center “Dr. Branko Zogović”, Plav, MontenegroUniversity of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia + Academy of Educational and Medical Vocational Studies, Ćuprija Department, Kruševac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia + University Clinical Center Kragujevac, Department of Dermatology, Kragujevac, SerbiaBackground/Aim. Psoriasis is a chronic multisystem, inflammatory, and immune-mediated dermatological disease of a relapsing nature. Not only does it affect objective parameters such as skin and joints, with different intensity involvement and with changes and the degree of changes, but it also significantly affects the health-related quality of life (QoL). The aim of the study was to determine the clinical severity and QoL of patients with moderate to severe psoriasis and examine the association between those parameters before and after the treatment. Methods. This cross-sectional study included 183 patients diagnosed with moderate to severe psoriasis. The severity of the clinical picture was determined by calculating the Psoriasis Area and Severity Index (PASI) by a dermatologist, while the QoL was assessed using the Dermatology Life Quality Index (DLQI) questionnaire and psoriasis-related stress by the Psoriasis Life Stress Inventory (PLSI). Disease severity and QoL were measured at the baseline visit and after the 16th week of therapy. Results. The average PASI score at the beginning of therapy was 23.1 ± 6 .5, while after 16 weeks, this value was 4.36 ± 4.86. The DLQI score was 20.8 ± 5.0 at the start of therapy and 6.20 ± 6 .16 after 16 weeks, while the PLSI score was 35.37 ± 8.84 initially and 12.75 ± 12.82 after 16 weeks of therapy. A strong correlation was found between PASI and PLSI scores (r = 0.702, р < 0.001) in the 16th week of therapy, while the correlation between DLQI and PASI scores was moderate (r = 0.683, р < 0.001). No significant differences between PASI and DLQI scores were found (r = 0.080, р = 0.284) nor between PASI and PLSI scores (r = 0.109, р = 0.140) at baseline. Conclusion. Patients with severe psoriasis experience a significant reduction in their QoL, accompanied by a high level of psychosocial stress. Observed improvements in QoL have shown a moderate correlation, while lower levels of psychosocial stress have strongly correlated with the severity of the clinical presentation, which may indicate a complex interaction between psychological factors and physical health in patients with psoriasis.https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300050M.pdfpsoriasisquality of lifeseverity of illness indexsurveys and questionnairesstress, psychological |
| spellingShingle | Milidrag Ardea Safiye Teodora Gutić Medo Zlatanović Milena Radević Svetlana Ravić-Nikolić Ana Correlation between clinical severity and quality of life in moderate to severe psoriasis patients: Real-world evidence Vojnosanitetski Pregled psoriasis quality of life severity of illness index surveys and questionnaires stress, psychological |
| title | Correlation between clinical severity and quality of life in moderate to severe psoriasis patients: Real-world evidence |
| title_full | Correlation between clinical severity and quality of life in moderate to severe psoriasis patients: Real-world evidence |
| title_fullStr | Correlation between clinical severity and quality of life in moderate to severe psoriasis patients: Real-world evidence |
| title_full_unstemmed | Correlation between clinical severity and quality of life in moderate to severe psoriasis patients: Real-world evidence |
| title_short | Correlation between clinical severity and quality of life in moderate to severe psoriasis patients: Real-world evidence |
| title_sort | correlation between clinical severity and quality of life in moderate to severe psoriasis patients real world evidence |
| topic | psoriasis quality of life severity of illness index surveys and questionnaires stress, psychological |
| url | https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300050M.pdf |
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