Cardioneuroablation for Vasovagal Syncope: An Updated Systematic Review and Single-Arm Meta-Analysis
<b>Background:</b> When conservative therapies are insufficient for vasovagal syncope (VVS), procedural options such as permanent pacemakers or catheter ablation of ganglionated plexi (GP) may be considered. This meta-analysis aimed to evaluate the efficacy of GP catheter ablation in pat...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/7/1758 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849405851618508800 |
|---|---|
| author | Alexandru Ababei Cosmin Gabriel Ursu Mircea Ioan Alexandru Bistriceanu Darie Ioan Andreescu Iasmina-Maria Iurea Beatrice Budeanu Adriana Elena Dumitrache Alexandra Hostiuc Maria-Celina Sturz-Lazar Cristian-Valentin Toma Stefan Sebastian Busnatu Alexandru Deaconu Stefan Bogdan |
| author_facet | Alexandru Ababei Cosmin Gabriel Ursu Mircea Ioan Alexandru Bistriceanu Darie Ioan Andreescu Iasmina-Maria Iurea Beatrice Budeanu Adriana Elena Dumitrache Alexandra Hostiuc Maria-Celina Sturz-Lazar Cristian-Valentin Toma Stefan Sebastian Busnatu Alexandru Deaconu Stefan Bogdan |
| author_sort | Alexandru Ababei |
| collection | DOAJ |
| description | <b>Background:</b> When conservative therapies are insufficient for vasovagal syncope (VVS), procedural options such as permanent pacemakers or catheter ablation of ganglionated plexi (GP) may be considered. This meta-analysis aimed to evaluate the efficacy of GP catheter ablation in patients with VVS. <b>Methods:</b> A comprehensive literature search was performed in PubMed, Embase, and the Cochrane Library from 15 March 2024 to 10 May 2025. After duplicate removal, two reviewers independently screened studies and assessed full texts based on predefined criteria. A single-arm proportion meta-analysis was conducted. <b>Results:</b> Thirty-seven studies comprising 1585 participants were included. The pooled proportion of VVS recurrence after ablation was 8.9% (95% CI, 6.4–11.4%), but with substantial heterogeneity (I<sup>2</sup> = 74.4%, <i>p</i> < 0.001). Sensitivity and subgroup analyses confirmed the robustness of the pooled estimate. A meta-regression was performed to further explore potential effect modifiers, but no covariate reached statistical significance. <b>Conclusions:</b> This meta-analysis suggests that ganglionated plexi catheter ablation may be associated with a reduced recurrence of vasovagal syncope in selected populations. However, the findings are based predominantly on non-randomized observational studies, and the high between-study heterogeneity limits the strength of inference. Future randomized controlled trials with standardized methodologies are needed to confirm the long-term efficacy and safety of this intervention. |
| format | Article |
| id | doaj-art-caf162d6534c4b7bbfb0a05674629bd8 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-caf162d6534c4b7bbfb0a05674629bd82025-08-20T03:36:34ZengMDPI AGBiomedicines2227-90592025-07-01137175810.3390/biomedicines13071758Cardioneuroablation for Vasovagal Syncope: An Updated Systematic Review and Single-Arm Meta-AnalysisAlexandru Ababei0Cosmin Gabriel Ursu1Mircea Ioan Alexandru Bistriceanu2Darie Ioan Andreescu3Iasmina-Maria Iurea4Beatrice Budeanu5Adriana Elena Dumitrache6Alexandra Hostiuc7Maria-Celina Sturz-Lazar8Cristian-Valentin Toma9Stefan Sebastian Busnatu10Alexandru Deaconu11Stefan Bogdan12Iliescu Emergency Institute for Cardiovascular Diseases, 022328 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania<b>Background:</b> When conservative therapies are insufficient for vasovagal syncope (VVS), procedural options such as permanent pacemakers or catheter ablation of ganglionated plexi (GP) may be considered. This meta-analysis aimed to evaluate the efficacy of GP catheter ablation in patients with VVS. <b>Methods:</b> A comprehensive literature search was performed in PubMed, Embase, and the Cochrane Library from 15 March 2024 to 10 May 2025. After duplicate removal, two reviewers independently screened studies and assessed full texts based on predefined criteria. A single-arm proportion meta-analysis was conducted. <b>Results:</b> Thirty-seven studies comprising 1585 participants were included. The pooled proportion of VVS recurrence after ablation was 8.9% (95% CI, 6.4–11.4%), but with substantial heterogeneity (I<sup>2</sup> = 74.4%, <i>p</i> < 0.001). Sensitivity and subgroup analyses confirmed the robustness of the pooled estimate. A meta-regression was performed to further explore potential effect modifiers, but no covariate reached statistical significance. <b>Conclusions:</b> This meta-analysis suggests that ganglionated plexi catheter ablation may be associated with a reduced recurrence of vasovagal syncope in selected populations. However, the findings are based predominantly on non-randomized observational studies, and the high between-study heterogeneity limits the strength of inference. Future randomized controlled trials with standardized methodologies are needed to confirm the long-term efficacy and safety of this intervention.https://www.mdpi.com/2227-9059/13/7/1758vasovagal syncopecardioneuroablationganglionated plexus |
| spellingShingle | Alexandru Ababei Cosmin Gabriel Ursu Mircea Ioan Alexandru Bistriceanu Darie Ioan Andreescu Iasmina-Maria Iurea Beatrice Budeanu Adriana Elena Dumitrache Alexandra Hostiuc Maria-Celina Sturz-Lazar Cristian-Valentin Toma Stefan Sebastian Busnatu Alexandru Deaconu Stefan Bogdan Cardioneuroablation for Vasovagal Syncope: An Updated Systematic Review and Single-Arm Meta-Analysis Biomedicines vasovagal syncope cardioneuroablation ganglionated plexus |
| title | Cardioneuroablation for Vasovagal Syncope: An Updated Systematic Review and Single-Arm Meta-Analysis |
| title_full | Cardioneuroablation for Vasovagal Syncope: An Updated Systematic Review and Single-Arm Meta-Analysis |
| title_fullStr | Cardioneuroablation for Vasovagal Syncope: An Updated Systematic Review and Single-Arm Meta-Analysis |
| title_full_unstemmed | Cardioneuroablation for Vasovagal Syncope: An Updated Systematic Review and Single-Arm Meta-Analysis |
| title_short | Cardioneuroablation for Vasovagal Syncope: An Updated Systematic Review and Single-Arm Meta-Analysis |
| title_sort | cardioneuroablation for vasovagal syncope an updated systematic review and single arm meta analysis |
| topic | vasovagal syncope cardioneuroablation ganglionated plexus |
| url | https://www.mdpi.com/2227-9059/13/7/1758 |
| work_keys_str_mv | AT alexandruababei cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis AT cosmingabrielursu cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis AT mirceaioanalexandrubistriceanu cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis AT darieioanandreescu cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis AT iasminamariaiurea cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis AT beatricebudeanu cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis AT adrianaelenadumitrache cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis AT alexandrahostiuc cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis AT mariacelinasturzlazar cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis AT cristianvalentintoma cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis AT stefansebastianbusnatu cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis AT alexandrudeaconu cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis AT stefanbogdan cardioneuroablationforvasovagalsyncopeanupdatedsystematicreviewandsinglearmmetaanalysis |