The role of gut microbiota dysbiosis in drug-induced brain injury: mechanisms and therapeutic implications

The role of gut microbiota dysbiosis in drug-induced brain injury: mechanisms and therapeutic implications

Drug-induced brain injury (DIBI) results from toxicity, interactions or misuse and is increasingly linked to gut-microbiota dysbiosis operating via the gut–brain axis. Disturbed microbial balance drives three core mechanisms—oxidative stress, neuroinflammation and metabolic dysfunction—leading to bl...

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Bibliographic Details
Main Authors: Jinghui Zhai, Yue Zhang, Shuyue Ma, Yingli Zhang, Miao Jin, Huiyu Yan, Sixi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
drug-induced brain injury
gut microbiota
gut-brain axis
neuroinflammation
blood-brain barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1604539/full
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