<i>Clostridium butyricum</i> Ameliorates Atherosclerosis by Regulating Host Linoleic Acid Metabolism
Dysbiosis of the gut microbiota is strongly implicated in atherosclerosis (AS), thus prompting microbial modulation to be explored as a therapeutic strategy. However, limited evidence exists for probiotic interventions capable of alleviating AS. Here, we focused on <i>Clostridium butyricum<...
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MDPI AG
2025-05-01
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| Online Access: | https://www.mdpi.com/2076-2607/13/6/1220 |
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| author | Chao Yin Peizhi Fan Xiangyu Mou Wenjing Zhao |
| author_facet | Chao Yin Peizhi Fan Xiangyu Mou Wenjing Zhao |
| author_sort | Chao Yin |
| collection | DOAJ |
| description | Dysbiosis of the gut microbiota is strongly implicated in atherosclerosis (AS), thus prompting microbial modulation to be explored as a therapeutic strategy. However, limited evidence exists for probiotic interventions capable of alleviating AS. Here, we focused on <i>Clostridium butyricum</i> (<i>C. butyricum</i>; CB), a probiotic known for its production of short-chain fatty acids (SCFAs). We found that administration of <i>C. butyricum</i> to high-fat diet (HFD)-fed <i>Apoe</i> deficient (<i>Apoe<sup>−/−</sup></i>) mice reduced plaque area by improving blood lipid profiles, decreasing macrophage infiltration in the aortic roots, and lowering the levels of circulating pro-inflammatory monocytes and macrophages. By non-targeted serum metabolomics analysis, <i>C. butyricum</i> treatment significantly reduced the levels of both linoleic acid and its downstream metabolites. Collectively, these findings establish <i>C. butyricum</i>-mediated amelioration of AS through modulation of linoleic acid metabolism. |
| format | Article |
| id | doaj-art-caea0f18fbdd4cbd956d4684dbbc06bc |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-caea0f18fbdd4cbd956d4684dbbc06bc2025-08-20T03:29:35ZengMDPI AGMicroorganisms2076-26072025-05-01136122010.3390/microorganisms13061220<i>Clostridium butyricum</i> Ameliorates Atherosclerosis by Regulating Host Linoleic Acid MetabolismChao Yin0Peizhi Fan1Xiangyu Mou2Wenjing Zhao3Shenzhen Key Laboratory for Systems Medicine for Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaShenzhen Key Laboratory for Systems Medicine for Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaShenzhen Key Laboratory for Systems Medicine for Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaShenzhen Key Laboratory for Systems Medicine for Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaDysbiosis of the gut microbiota is strongly implicated in atherosclerosis (AS), thus prompting microbial modulation to be explored as a therapeutic strategy. However, limited evidence exists for probiotic interventions capable of alleviating AS. Here, we focused on <i>Clostridium butyricum</i> (<i>C. butyricum</i>; CB), a probiotic known for its production of short-chain fatty acids (SCFAs). We found that administration of <i>C. butyricum</i> to high-fat diet (HFD)-fed <i>Apoe</i> deficient (<i>Apoe<sup>−/−</sup></i>) mice reduced plaque area by improving blood lipid profiles, decreasing macrophage infiltration in the aortic roots, and lowering the levels of circulating pro-inflammatory monocytes and macrophages. By non-targeted serum metabolomics analysis, <i>C. butyricum</i> treatment significantly reduced the levels of both linoleic acid and its downstream metabolites. Collectively, these findings establish <i>C. butyricum</i>-mediated amelioration of AS through modulation of linoleic acid metabolism.https://www.mdpi.com/2076-2607/13/6/1220<i>Clostridium butyricum</i>ASlinoleic acidinflammation |
| spellingShingle | Chao Yin Peizhi Fan Xiangyu Mou Wenjing Zhao <i>Clostridium butyricum</i> Ameliorates Atherosclerosis by Regulating Host Linoleic Acid Metabolism Microorganisms <i>Clostridium butyricum</i> AS linoleic acid inflammation |
| title | <i>Clostridium butyricum</i> Ameliorates Atherosclerosis by Regulating Host Linoleic Acid Metabolism |
| title_full | <i>Clostridium butyricum</i> Ameliorates Atherosclerosis by Regulating Host Linoleic Acid Metabolism |
| title_fullStr | <i>Clostridium butyricum</i> Ameliorates Atherosclerosis by Regulating Host Linoleic Acid Metabolism |
| title_full_unstemmed | <i>Clostridium butyricum</i> Ameliorates Atherosclerosis by Regulating Host Linoleic Acid Metabolism |
| title_short | <i>Clostridium butyricum</i> Ameliorates Atherosclerosis by Regulating Host Linoleic Acid Metabolism |
| title_sort | i clostridium butyricum i ameliorates atherosclerosis by regulating host linoleic acid metabolism |
| topic | <i>Clostridium butyricum</i> AS linoleic acid inflammation |
| url | https://www.mdpi.com/2076-2607/13/6/1220 |
| work_keys_str_mv | AT chaoyin iclostridiumbutyricumiamelioratesatherosclerosisbyregulatinghostlinoleicacidmetabolism AT peizhifan iclostridiumbutyricumiamelioratesatherosclerosisbyregulatinghostlinoleicacidmetabolism AT xiangyumou iclostridiumbutyricumiamelioratesatherosclerosisbyregulatinghostlinoleicacidmetabolism AT wenjingzhao iclostridiumbutyricumiamelioratesatherosclerosisbyregulatinghostlinoleicacidmetabolism |