An unbiased tissue transcriptome analysis identifies potential markers for skin phenotypes and therapeutic responses in atopic dermatitis

An unbiased tissue transcriptome analysis identifies potential markers for skin phenotypes and therapeutic responses in atopic dermatitis

Abstract Atopic dermatitis (AD) is a skin disease exhibiting clinical and molecular heterogeneity, thereby jeopardizing the development of personalized treatments. Here we pursue a cross-sectional and longitudinal cohort analysis of 951 whole-skin samples, employing an unsupervised decomposition ana...

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Main Authors: Ayano Fukushima-Nomura, Hiroshi Kawasaki, Kiyoshi Yashiro, Shoko Obata, Keiji Tanese, Tamotsu Ebihara, Hidehisa Saeki, Takafumi Etoh, Takehiro Hasegawa, Junshi Yazaki, Jun Seita, Osamu Ohara, Aiko Sekita, Tomohiro Miyai, Koichi Ashizaki, Haruhiko Koseki, Kazuhiro Sakurada, Eiryo Kawakami, Masayuki Amagai
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59340-x
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