Cell Death Mechanisms Produced by Carbon-Based Nanoparticles
Using carbon-based nanoparticles, such as diamond, graphite, fullerene, and nanotubes, has increased their research as possible strategies for drug delivery to control diseases, especially cancer. However, because these materials, when interacting with the living environment, release substances that...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/jnt/9961520 |
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| author | Santos-Adriana Martel-Estrada Claudia-Lucía Vargas-Requena Josue-Itan Sifuentes-Chavarría Maileth-Yoelis Yepes-Mendoza Daniel-Santiago Palacio-Castillo Florinda Jimenez-Vega Imelda Olivas-Armendáriz |
| author_facet | Santos-Adriana Martel-Estrada Claudia-Lucía Vargas-Requena Josue-Itan Sifuentes-Chavarría Maileth-Yoelis Yepes-Mendoza Daniel-Santiago Palacio-Castillo Florinda Jimenez-Vega Imelda Olivas-Armendáriz |
| author_sort | Santos-Adriana Martel-Estrada |
| collection | DOAJ |
| description | Using carbon-based nanoparticles, such as diamond, graphite, fullerene, and nanotubes, has increased their research as possible strategies for drug delivery to control diseases, especially cancer. However, because these materials, when interacting with the living environment, release substances that are capable of inducing cell death by themselves, it is of vital importance to analyze the type of cell death that the particle can induce. Although there are different efforts to describe the kind of nanoparticles used to treat diseases such as cancer, no paper explains the mechanisms of cell death induced by different nanoparticle systems. Therefore, this paper attempts to gain cutting-edge information on using carbon-based nanopolymorphisms and the mechanism of cell death that the particles produce. In conclusion, carbon nanoparticles can interact directly with cell membranes, causing physical damage and disturbing the integrity of the membrane. This alteration can mainly lead to cell death by necrosis or apoptosis. The definition of a predominant mechanism for each nanoparticle depends on a dose-dependent manner. Primarily, the concentrations used to analyze cytotoxicity were 100–500 μg/mL. In several studies analyzed, it was only possible to find that the nanodiamonds proved not to be cytotoxic. |
| format | Article |
| id | doaj-art-cadaadbde61f49a6add0e4ee007dd89c |
| institution | OA Journals |
| issn | 1687-9511 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-cadaadbde61f49a6add0e4ee007dd89c2025-08-20T02:12:19ZengWileyJournal of Nanotechnology1687-95112025-01-01202510.1155/jnt/9961520Cell Death Mechanisms Produced by Carbon-Based NanoparticlesSantos-Adriana Martel-Estrada0Claudia-Lucía Vargas-Requena1Josue-Itan Sifuentes-Chavarría2Maileth-Yoelis Yepes-Mendoza3Daniel-Santiago Palacio-Castillo4Florinda Jimenez-Vega5Imelda Olivas-Armendáriz6Architecture, Design, and Art InstituteBiomedical Sciences InstituteBiomedical Sciences InstituteEngineering FacultyEngineering FacultyBiomedical Sciences InstituteDepartment of Physics and MathematicsUsing carbon-based nanoparticles, such as diamond, graphite, fullerene, and nanotubes, has increased their research as possible strategies for drug delivery to control diseases, especially cancer. However, because these materials, when interacting with the living environment, release substances that are capable of inducing cell death by themselves, it is of vital importance to analyze the type of cell death that the particle can induce. Although there are different efforts to describe the kind of nanoparticles used to treat diseases such as cancer, no paper explains the mechanisms of cell death induced by different nanoparticle systems. Therefore, this paper attempts to gain cutting-edge information on using carbon-based nanopolymorphisms and the mechanism of cell death that the particles produce. In conclusion, carbon nanoparticles can interact directly with cell membranes, causing physical damage and disturbing the integrity of the membrane. This alteration can mainly lead to cell death by necrosis or apoptosis. The definition of a predominant mechanism for each nanoparticle depends on a dose-dependent manner. Primarily, the concentrations used to analyze cytotoxicity were 100–500 μg/mL. In several studies analyzed, it was only possible to find that the nanodiamonds proved not to be cytotoxic.http://dx.doi.org/10.1155/jnt/9961520 |
| spellingShingle | Santos-Adriana Martel-Estrada Claudia-Lucía Vargas-Requena Josue-Itan Sifuentes-Chavarría Maileth-Yoelis Yepes-Mendoza Daniel-Santiago Palacio-Castillo Florinda Jimenez-Vega Imelda Olivas-Armendáriz Cell Death Mechanisms Produced by Carbon-Based Nanoparticles Journal of Nanotechnology |
| title | Cell Death Mechanisms Produced by Carbon-Based Nanoparticles |
| title_full | Cell Death Mechanisms Produced by Carbon-Based Nanoparticles |
| title_fullStr | Cell Death Mechanisms Produced by Carbon-Based Nanoparticles |
| title_full_unstemmed | Cell Death Mechanisms Produced by Carbon-Based Nanoparticles |
| title_short | Cell Death Mechanisms Produced by Carbon-Based Nanoparticles |
| title_sort | cell death mechanisms produced by carbon based nanoparticles |
| url | http://dx.doi.org/10.1155/jnt/9961520 |
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