Management of Primary Sclerosing Cholangitis: Conventions and Controversies
Primary sclerosing cholangitis (PSC) is a chronic inflammatory cholangiopathy that results in fibrotic strictures and dilations of the intra- and extrahepatic bile ducts. PSC is uncommon, occurs predominantly in males and has a strong association with inflammatory bowel disease. While the pathogenes...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2012/426430 |
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| _version_ | 1832554664075198464 |
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| author | Natasha Chandok Gideon M Hirschfield |
| author_facet | Natasha Chandok Gideon M Hirschfield |
| author_sort | Natasha Chandok |
| collection | DOAJ |
| description | Primary sclerosing cholangitis (PSC) is a chronic inflammatory cholangiopathy that results in fibrotic strictures and dilations of the intra- and extrahepatic bile ducts. PSC is uncommon, occurs predominantly in males and has a strong association with inflammatory bowel disease. While the pathogenesis of PSC has not been fully elucidated, emerging evidence supports roles for the innate and adaptive immune systems, and genome-wide analyses have identified several genetic associations. Using the best available evidence, the present review summarizes the current understanding of the diagnosis, pathogenesis and management of PSC. Despite its rarity, there is an urgent need for collaborative research efforts to advance therapeutic options for PSC beyond liver transplantation. |
| format | Article |
| id | doaj-art-cad0db5f178c48bab922183f9417837c |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-cad0db5f178c48bab922183f9417837c2025-02-03T05:50:56ZengWileyCanadian Journal of Gastroenterology0835-79002012-01-0126526126810.1155/2012/426430Management of Primary Sclerosing Cholangitis: Conventions and ControversiesNatasha Chandok0Gideon M Hirschfield1Division of Gastroenterology, Western University, London, CanadaDepartment of Medicine, University of Toronto, Toronto, Ontario, CanadaPrimary sclerosing cholangitis (PSC) is a chronic inflammatory cholangiopathy that results in fibrotic strictures and dilations of the intra- and extrahepatic bile ducts. PSC is uncommon, occurs predominantly in males and has a strong association with inflammatory bowel disease. While the pathogenesis of PSC has not been fully elucidated, emerging evidence supports roles for the innate and adaptive immune systems, and genome-wide analyses have identified several genetic associations. Using the best available evidence, the present review summarizes the current understanding of the diagnosis, pathogenesis and management of PSC. Despite its rarity, there is an urgent need for collaborative research efforts to advance therapeutic options for PSC beyond liver transplantation.http://dx.doi.org/10.1155/2012/426430 |
| spellingShingle | Natasha Chandok Gideon M Hirschfield Management of Primary Sclerosing Cholangitis: Conventions and Controversies Canadian Journal of Gastroenterology |
| title | Management of Primary Sclerosing Cholangitis: Conventions and Controversies |
| title_full | Management of Primary Sclerosing Cholangitis: Conventions and Controversies |
| title_fullStr | Management of Primary Sclerosing Cholangitis: Conventions and Controversies |
| title_full_unstemmed | Management of Primary Sclerosing Cholangitis: Conventions and Controversies |
| title_short | Management of Primary Sclerosing Cholangitis: Conventions and Controversies |
| title_sort | management of primary sclerosing cholangitis conventions and controversies |
| url | http://dx.doi.org/10.1155/2012/426430 |
| work_keys_str_mv | AT natashachandok managementofprimarysclerosingcholangitisconventionsandcontroversies AT gideonmhirschfield managementofprimarysclerosingcholangitisconventionsandcontroversies |