Cardiovascular Risk in Chronic Kidney Disease: Role of the Sympathetic Nervous System
Patients with chronic kidney disease are at significantly increased risk for cardiovascular disease and sudden cardiac death. One mechanism underlying increased cardiovascular risk in patients with renal failure includes overactivation of the sympathetic nervous system (SNS). Multiple human and anim...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/319432 |
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| _version_ | 1832555564446515200 |
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| author | Jeanie Park |
| author_facet | Jeanie Park |
| author_sort | Jeanie Park |
| collection | DOAJ |
| description | Patients with chronic kidney disease are at significantly increased risk for cardiovascular disease and sudden cardiac death. One mechanism underlying increased cardiovascular risk in patients with renal failure includes overactivation of the sympathetic nervous system (SNS). Multiple human and animal studies have shown that central sympathetic outflow is chronically elevated in patients with both end-stage renal disease (ESRD) and chronic kidney disease (CKD). SNS overactivation, in turn, increases the risk of cardiovascular disease and sudden death by increasing arterial blood pressure, arrythmogenicity, left ventricular hypertrophy, and coronary vasoconstriction and contributes to the progression renal disease. This paper will examine the evidence for SNS overactivation in renal failure from both human and experimental studies and discuss mechanisms of SNS overactivity in CKD and therapeutic implications. |
| format | Article |
| id | doaj-art-cace544d42484389a54dc9c790051a51 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-cace544d42484389a54dc9c790051a512025-02-03T05:47:57ZengWileyCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/319432319432Cardiovascular Risk in Chronic Kidney Disease: Role of the Sympathetic Nervous SystemJeanie Park0Renal Division, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, WMB 338, Atlanta, GA 30322, USAPatients with chronic kidney disease are at significantly increased risk for cardiovascular disease and sudden cardiac death. One mechanism underlying increased cardiovascular risk in patients with renal failure includes overactivation of the sympathetic nervous system (SNS). Multiple human and animal studies have shown that central sympathetic outflow is chronically elevated in patients with both end-stage renal disease (ESRD) and chronic kidney disease (CKD). SNS overactivation, in turn, increases the risk of cardiovascular disease and sudden death by increasing arterial blood pressure, arrythmogenicity, left ventricular hypertrophy, and coronary vasoconstriction and contributes to the progression renal disease. This paper will examine the evidence for SNS overactivation in renal failure from both human and experimental studies and discuss mechanisms of SNS overactivity in CKD and therapeutic implications.http://dx.doi.org/10.1155/2012/319432 |
| spellingShingle | Jeanie Park Cardiovascular Risk in Chronic Kidney Disease: Role of the Sympathetic Nervous System Cardiology Research and Practice |
| title | Cardiovascular Risk in Chronic Kidney Disease: Role of the Sympathetic Nervous System |
| title_full | Cardiovascular Risk in Chronic Kidney Disease: Role of the Sympathetic Nervous System |
| title_fullStr | Cardiovascular Risk in Chronic Kidney Disease: Role of the Sympathetic Nervous System |
| title_full_unstemmed | Cardiovascular Risk in Chronic Kidney Disease: Role of the Sympathetic Nervous System |
| title_short | Cardiovascular Risk in Chronic Kidney Disease: Role of the Sympathetic Nervous System |
| title_sort | cardiovascular risk in chronic kidney disease role of the sympathetic nervous system |
| url | http://dx.doi.org/10.1155/2012/319432 |
| work_keys_str_mv | AT jeaniepark cardiovascularriskinchronickidneydiseaseroleofthesympatheticnervoussystem |