Comparative effectiveness of antihypertensive agents in hypothyreosis patients
Aim. To assess various antihypertensive agents’ effects on arterial hypertension (AH) severity in hypothyrosispatients.Material and methods. In total, 81 patients with moderate primary hypothyrosis and Stage I-III AH were examined. General clinical examination, hormone level measurement, thyroid ult...
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«SILICEA-POLIGRAF» LLC
2008-02-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1052 |
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| author | E. T. Dykhne A. S. Galyavich |
| author_facet | E. T. Dykhne A. S. Galyavich |
| author_sort | E. T. Dykhne |
| collection | DOAJ |
| description | Aim. To assess various antihypertensive agents’ effects on arterial hypertension (AH) severity in hypothyrosispatients.Material and methods. In total, 81 patients with moderate primary hypothyrosis and Stage I-III AH were examined. General clinical examination, hormone level measurement, thyroid ultrasound, blood biochemistry assay(lipid profile, glucose, creatinine, potassium levels), electrocardiography, and echocardiography were performed.The participants were divided into four groups, receiving imidazoline receptor agonist rilmenidine (Group 1),ACE inhibitor spirapril (Group 2), diuretic indapamide (Group 3), and dihydropyridine calcium antagonistamlodipine (Group 4).Results. Spirapril reduced systolic and diastolic blood pressure (SBP, DBP) by 9,1% and 7,1%, amlodipine – by10,7% and 9,6%, rilmenidine – by 8,3% and 7,8%, respectively. Antihypertensive effectiveness of indapamidemonotherapy was problematic to assess, as only 1/3 of the patients received this treatment. Nevertheless, in indapamide group SBP and DBP reduction was greater (10,5% and 8,4%, respectively) than in spirapril and rilmenidine groups, where 75% and 68,4% of the subjects received monotherapy, respectively.Conclusion. Considering good antihypertensive effect of indapamide, mostly in combination with another antihypertensive agent, target BP level in hypothyrosis patients should be achieved by combined therapy, includingdiuretic. |
| format | Article |
| id | doaj-art-cac28094faed45f4a427b2833fd833a9 |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2008-02-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-cac28094faed45f4a427b2833fd833a92025-08-20T02:59:54Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252008-02-01711114765Comparative effectiveness of antihypertensive agents in hypothyreosis patientsE. T. Dykhne0A. S. Galyavich1Kazan State Medical University, KazanKazan State Medical University, KazanAim. To assess various antihypertensive agents’ effects on arterial hypertension (AH) severity in hypothyrosispatients.Material and methods. In total, 81 patients with moderate primary hypothyrosis and Stage I-III AH were examined. General clinical examination, hormone level measurement, thyroid ultrasound, blood biochemistry assay(lipid profile, glucose, creatinine, potassium levels), electrocardiography, and echocardiography were performed.The participants were divided into four groups, receiving imidazoline receptor agonist rilmenidine (Group 1),ACE inhibitor spirapril (Group 2), diuretic indapamide (Group 3), and dihydropyridine calcium antagonistamlodipine (Group 4).Results. Spirapril reduced systolic and diastolic blood pressure (SBP, DBP) by 9,1% and 7,1%, amlodipine – by10,7% and 9,6%, rilmenidine – by 8,3% and 7,8%, respectively. Antihypertensive effectiveness of indapamidemonotherapy was problematic to assess, as only 1/3 of the patients received this treatment. Nevertheless, in indapamide group SBP and DBP reduction was greater (10,5% and 8,4%, respectively) than in spirapril and rilmenidine groups, where 75% and 68,4% of the subjects received monotherapy, respectively.Conclusion. Considering good antihypertensive effect of indapamide, mostly in combination with another antihypertensive agent, target BP level in hypothyrosis patients should be achieved by combined therapy, includingdiuretic.https://cardiovascular.elpub.ru/jour/article/view/1052arterial hypertensionhypothyrosisantihypertensive agents |
| spellingShingle | E. T. Dykhne A. S. Galyavich Comparative effectiveness of antihypertensive agents in hypothyreosis patients Кардиоваскулярная терапия и профилактика arterial hypertension hypothyrosis antihypertensive agents |
| title | Comparative effectiveness of antihypertensive agents in hypothyreosis patients |
| title_full | Comparative effectiveness of antihypertensive agents in hypothyreosis patients |
| title_fullStr | Comparative effectiveness of antihypertensive agents in hypothyreosis patients |
| title_full_unstemmed | Comparative effectiveness of antihypertensive agents in hypothyreosis patients |
| title_short | Comparative effectiveness of antihypertensive agents in hypothyreosis patients |
| title_sort | comparative effectiveness of antihypertensive agents in hypothyreosis patients |
| topic | arterial hypertension hypothyrosis antihypertensive agents |
| url | https://cardiovascular.elpub.ru/jour/article/view/1052 |
| work_keys_str_mv | AT etdykhne comparativeeffectivenessofantihypertensiveagentsinhypothyreosispatients AT asgalyavich comparativeeffectivenessofantihypertensiveagentsinhypothyreosispatients |