Astaxanthin attenuates DNA fragmentation and cognitive decline in type 2 diabetic rats
Abstract Potential properties of astaxanthin include immunomodulation, antioxidant, and anti-inflammatory effects. In diabetic rats, we examined the potential impacts and underlying mechanisms of astaxanthin on hippocampal DNA, cognition, and glycemic status. Rats were divided into five equal groups...
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| Format: | Article |
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Nature Portfolio
2025-06-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-04402-9 |
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| author | Sohair A. Saleh Gergess S. Hanna Sobhy H. El-Naby Suzy F. Ewida Rasha S. A. Elseadawy Basma S. Ghoneim Shaimaa M. Motawea |
| author_facet | Sohair A. Saleh Gergess S. Hanna Sobhy H. El-Naby Suzy F. Ewida Rasha S. A. Elseadawy Basma S. Ghoneim Shaimaa M. Motawea |
| author_sort | Sohair A. Saleh |
| collection | DOAJ |
| description | Abstract Potential properties of astaxanthin include immunomodulation, antioxidant, and anti-inflammatory effects. In diabetic rats, we examined the potential impacts and underlying mechanisms of astaxanthin on hippocampal DNA, cognition, and glycemic status. Rats were divided into five equal groups: non-diabetic, and diabetic (non-treated, metformin treated, astaxanthin treated, and treated with a combination of metformin and astaxanthin). Both spatial and non-spatial memory and learning were assessed. IL-6, malondialdehyde, total antioxidant capacity, lipid profile, and glycemic status were assessed. Phosphorylated tau expression level was measured, and H&E section analysis was used to evaluate the hippocampal tissue. DNA fragmentation, intact DNA, and hippocampal RNA were evaluated. Induction of diabetes led to a reduction in cognitive abilities along with significant hyperglycemia, dyslipidemia, oxidative stress, hyperphosphorylation of tau, and DNA fragmentation. Astaxanthin as monotherapy or in combination with metformin improved cognitive functions with reduction of hyperglycemia, dyslipidemia, oxidative stress, hyperphosphorylation of tau, and DNA fragmentation. |
| format | Article |
| id | doaj-art-cac1acdbc0da45b9af44491f06884aec |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-cac1acdbc0da45b9af44491f06884aec2025-08-20T02:37:14ZengNature PortfolioScientific Reports2045-23222025-06-0115111310.1038/s41598-025-04402-9Astaxanthin attenuates DNA fragmentation and cognitive decline in type 2 diabetic ratsSohair A. Saleh0Gergess S. Hanna1Sobhy H. El-Naby2Suzy F. Ewida3Rasha S. A. Elseadawy4Basma S. Ghoneim5Shaimaa M. Motawea6Clinical Physiology Department, Faculty of Medicine, Menoufia UniversityClinical Physiology Department, Faculty of Medicine, Menoufia UniversityGenetics and Molecular Biology, Faculty of Science, Menoufia UniversityClinical Physiology Department, Faculty of Medicine, Menoufia UniversityNeurology Department, Faculty of Medicine, Menoufia UniversityClinical Physiology Department, Faculty of Medicine, Menoufia UniversityClinical Physiology Department, Faculty of Medicine, Menoufia UniversityAbstract Potential properties of astaxanthin include immunomodulation, antioxidant, and anti-inflammatory effects. In diabetic rats, we examined the potential impacts and underlying mechanisms of astaxanthin on hippocampal DNA, cognition, and glycemic status. Rats were divided into five equal groups: non-diabetic, and diabetic (non-treated, metformin treated, astaxanthin treated, and treated with a combination of metformin and astaxanthin). Both spatial and non-spatial memory and learning were assessed. IL-6, malondialdehyde, total antioxidant capacity, lipid profile, and glycemic status were assessed. Phosphorylated tau expression level was measured, and H&E section analysis was used to evaluate the hippocampal tissue. DNA fragmentation, intact DNA, and hippocampal RNA were evaluated. Induction of diabetes led to a reduction in cognitive abilities along with significant hyperglycemia, dyslipidemia, oxidative stress, hyperphosphorylation of tau, and DNA fragmentation. Astaxanthin as monotherapy or in combination with metformin improved cognitive functions with reduction of hyperglycemia, dyslipidemia, oxidative stress, hyperphosphorylation of tau, and DNA fragmentation.https://doi.org/10.1038/s41598-025-04402-9AstaxanthinCognitionHippocampus DNAPhosphorylated tauDiabetes type 2 |
| spellingShingle | Sohair A. Saleh Gergess S. Hanna Sobhy H. El-Naby Suzy F. Ewida Rasha S. A. Elseadawy Basma S. Ghoneim Shaimaa M. Motawea Astaxanthin attenuates DNA fragmentation and cognitive decline in type 2 diabetic rats Scientific Reports Astaxanthin Cognition Hippocampus DNA Phosphorylated tau Diabetes type 2 |
| title | Astaxanthin attenuates DNA fragmentation and cognitive decline in type 2 diabetic rats |
| title_full | Astaxanthin attenuates DNA fragmentation and cognitive decline in type 2 diabetic rats |
| title_fullStr | Astaxanthin attenuates DNA fragmentation and cognitive decline in type 2 diabetic rats |
| title_full_unstemmed | Astaxanthin attenuates DNA fragmentation and cognitive decline in type 2 diabetic rats |
| title_short | Astaxanthin attenuates DNA fragmentation and cognitive decline in type 2 diabetic rats |
| title_sort | astaxanthin attenuates dna fragmentation and cognitive decline in type 2 diabetic rats |
| topic | Astaxanthin Cognition Hippocampus DNA Phosphorylated tau Diabetes type 2 |
| url | https://doi.org/10.1038/s41598-025-04402-9 |
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