Anti-programmed death-1 inhibitors and nimotuzumab in combination with induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma: a propensity score-matched analysis
Background: The poor prognosis of locoregionally advanced nasopharyngeal carcinoma (LANPC) due to the high incidence of metastasis necessitates effective treatment strategies. Synergistic effects have been observed when anti-programmed death-1 (PD-1) inhibitors are combined with chemotherapy or targ...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Therapeutic Advances in Medical Oncology |
| Online Access: | https://doi.org/10.1177/17588359251316094 |
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| author | Ya-Ni Zhang Yu-Pei Chen Pu-Yun OuYang Tai-Xiang Lu Fang-Yun Xie Fei Han Chun-Yan Chen |
| author_facet | Ya-Ni Zhang Yu-Pei Chen Pu-Yun OuYang Tai-Xiang Lu Fang-Yun Xie Fei Han Chun-Yan Chen |
| author_sort | Ya-Ni Zhang |
| collection | DOAJ |
| description | Background: The poor prognosis of locoregionally advanced nasopharyngeal carcinoma (LANPC) due to the high incidence of metastasis necessitates effective treatment strategies. Synergistic effects have been observed when anti-programmed death-1 (PD-1) inhibitors are combined with chemotherapy or targeted therapy. Objectives: To compare the efficacy and safety of induction chemotherapy in combination with nimotuzumab with or without anti-PD-1 inhibitors for LANPC. Design: Retrospective study. Methods: In total, 319 patients with LANPC were retrospectively enrolled between December 2017 and November 2022. The primary endpoint was progression-free survival (PFS). Propensity score matching was performed to adjust for potential confounders. Results: Overall, 150 patients were included after propensity score matching. The immunotherapy + nimotuzumab + chemotherapy (INC) group ( n = 50) had a higher 3-year PFS rate (96.6% (95% confidence interval (CI): 93.2–100.0)) than the nimotuzumab + chemotherapy (NC) group ( n = 100) (79.8% (95% CI: 75.6–84.0)). The INC group had a hazard ratio of 0.16 (95% CI: 0.02–1.22; p = 0.04). The objective response rates were 100% and 99% for the INC and NC groups, respectively. Grade ⩾3 treatment-related adverse events were reported in eight (5.3%) patients, and hyponatremia (2.0%) was the most common. Grade ⩾3 immune-related adverse events (rash and reactive capillary proliferation) were reported in two (4.0%) patients. Conclusion: INC demonstrated remarkable anti-tumor activity with acceptable safety for LANPC. |
| format | Article |
| id | doaj-art-cabff4c74029459cac9910f8027c4d0a |
| institution | Kabale University |
| issn | 1758-8359 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Medical Oncology |
| spelling | doaj-art-cabff4c74029459cac9910f8027c4d0a2025-01-31T14:04:45ZengSAGE PublishingTherapeutic Advances in Medical Oncology1758-83592025-01-011710.1177/17588359251316094Anti-programmed death-1 inhibitors and nimotuzumab in combination with induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma: a propensity score-matched analysisYa-Ni ZhangYu-Pei ChenPu-Yun OuYangTai-Xiang LuFang-Yun XieFei HanChun-Yan ChenBackground: The poor prognosis of locoregionally advanced nasopharyngeal carcinoma (LANPC) due to the high incidence of metastasis necessitates effective treatment strategies. Synergistic effects have been observed when anti-programmed death-1 (PD-1) inhibitors are combined with chemotherapy or targeted therapy. Objectives: To compare the efficacy and safety of induction chemotherapy in combination with nimotuzumab with or without anti-PD-1 inhibitors for LANPC. Design: Retrospective study. Methods: In total, 319 patients with LANPC were retrospectively enrolled between December 2017 and November 2022. The primary endpoint was progression-free survival (PFS). Propensity score matching was performed to adjust for potential confounders. Results: Overall, 150 patients were included after propensity score matching. The immunotherapy + nimotuzumab + chemotherapy (INC) group ( n = 50) had a higher 3-year PFS rate (96.6% (95% confidence interval (CI): 93.2–100.0)) than the nimotuzumab + chemotherapy (NC) group ( n = 100) (79.8% (95% CI: 75.6–84.0)). The INC group had a hazard ratio of 0.16 (95% CI: 0.02–1.22; p = 0.04). The objective response rates were 100% and 99% for the INC and NC groups, respectively. Grade ⩾3 treatment-related adverse events were reported in eight (5.3%) patients, and hyponatremia (2.0%) was the most common. Grade ⩾3 immune-related adverse events (rash and reactive capillary proliferation) were reported in two (4.0%) patients. Conclusion: INC demonstrated remarkable anti-tumor activity with acceptable safety for LANPC.https://doi.org/10.1177/17588359251316094 |
| spellingShingle | Ya-Ni Zhang Yu-Pei Chen Pu-Yun OuYang Tai-Xiang Lu Fang-Yun Xie Fei Han Chun-Yan Chen Anti-programmed death-1 inhibitors and nimotuzumab in combination with induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma: a propensity score-matched analysis Therapeutic Advances in Medical Oncology |
| title | Anti-programmed death-1 inhibitors and nimotuzumab in combination with induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma: a propensity score-matched analysis |
| title_full | Anti-programmed death-1 inhibitors and nimotuzumab in combination with induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma: a propensity score-matched analysis |
| title_fullStr | Anti-programmed death-1 inhibitors and nimotuzumab in combination with induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma: a propensity score-matched analysis |
| title_full_unstemmed | Anti-programmed death-1 inhibitors and nimotuzumab in combination with induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma: a propensity score-matched analysis |
| title_short | Anti-programmed death-1 inhibitors and nimotuzumab in combination with induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma: a propensity score-matched analysis |
| title_sort | anti programmed death 1 inhibitors and nimotuzumab in combination with induction chemotherapy for locoregionally advanced nasopharyngeal carcinoma a propensity score matched analysis |
| url | https://doi.org/10.1177/17588359251316094 |
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