Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD
Despite the acknowledged contribution of eosinophils to the disease pathogenesis, available data on cytokines closely related to the peripheral eosinophils in inflammatory bowel disease (IBD) are scattered. We assessed the concentrations of eosinophil-associated cytokines and growth factors in the g...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/7265812 |
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| author | Katarzyna Neubauer Malgorzata Matusiewicz Iwona Bednarz-Misa Sabina Gorska Andrzej Gamian Malgorzata Krzystek-Korpacka |
| author_facet | Katarzyna Neubauer Malgorzata Matusiewicz Iwona Bednarz-Misa Sabina Gorska Andrzej Gamian Malgorzata Krzystek-Korpacka |
| author_sort | Katarzyna Neubauer |
| collection | DOAJ |
| description | Despite the acknowledged contribution of eosinophils to the disease pathogenesis, available data on cytokines closely related to the peripheral eosinophils in inflammatory bowel disease (IBD) are scattered. We assessed the concentrations of eosinophil-associated cytokines and growth factors in the group of 277 individuals (101 patients with Crohn’s disease (CD), 77 with ulcerative colitis (UC), 16 with irritable bowel syndrome (IBS), and 83 healthy controls) and referred to IBD activity and the levels of hsCRP. As compared to IBS patients or healthy controls, patients with CD had significantly higher levels of IL5, IL8, IL12(p70), GM-CSF, and TNFα and patients with UC, the levels of eotaxin, IL4, IL5, IL8, IL12(p70), IL13, GM-CSF, and TNFα were also higher. As compared to CD patients, patients with UC had significantly higher levels of eotaxin, IL4, IL5, IL8, and IL1. In turn, the concentrations of hsCRP were significantly higher in CD than UC. Except for IL13, all cytokines and hsCRP positively correlated with CDAI. In UC, a positive correlation with MDAI was observed for hsCRP, GM-CSF, IL12(p70), and IFNγ and a negative one for IL8. The concentrations of hsCRP, GM-CSF, IFNγ, IL12(p70), and RANTES were higher in UC patients with active than inactive disease whereas those of IL8 and TNFα were significantly lower. Eotaxin, determined individually or in a panel with IFNγ and hsCRP, showed fair accuracy in differentiating CD from UC. If confirmed on a larger representation of IBS patients, IL8 might support differential diagnosis of organic and functional conditions of the bowel. GM-CSF, in turn, demonstrated to be an excellent indicator of bowel inflammation and may be taken into consideration as a noninvasive marker of mucosal healing. In summary, eosinophil-associated cytokines are elevated in IBD, more pronouncedly in UC, and may support the differential diagnosis of IBD and aid in monitoring of mucosal healing. |
| format | Article |
| id | doaj-art-cabd33954e594521a7cfb36124a8b2ed |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-cabd33954e594521a7cfb36124a8b2ed2025-02-03T01:12:24ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/72658127265812Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBDKatarzyna Neubauer0Malgorzata Matusiewicz1Iwona Bednarz-Misa2Sabina Gorska3Andrzej Gamian4Malgorzata Krzystek-Korpacka5Department of Gastroenterology and Hepatology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Medical Biochemistry, Wroclaw Medical University, 50-368 Wroclaw, PolandDepartment of Medical Biochemistry, Wroclaw Medical University, 50-368 Wroclaw, PolandLaboratory of Medical Microbiology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, PolandDepartment of Medical Biochemistry, Wroclaw Medical University, 50-368 Wroclaw, PolandDepartment of Medical Biochemistry, Wroclaw Medical University, 50-368 Wroclaw, PolandDespite the acknowledged contribution of eosinophils to the disease pathogenesis, available data on cytokines closely related to the peripheral eosinophils in inflammatory bowel disease (IBD) are scattered. We assessed the concentrations of eosinophil-associated cytokines and growth factors in the group of 277 individuals (101 patients with Crohn’s disease (CD), 77 with ulcerative colitis (UC), 16 with irritable bowel syndrome (IBS), and 83 healthy controls) and referred to IBD activity and the levels of hsCRP. As compared to IBS patients or healthy controls, patients with CD had significantly higher levels of IL5, IL8, IL12(p70), GM-CSF, and TNFα and patients with UC, the levels of eotaxin, IL4, IL5, IL8, IL12(p70), IL13, GM-CSF, and TNFα were also higher. As compared to CD patients, patients with UC had significantly higher levels of eotaxin, IL4, IL5, IL8, and IL1. In turn, the concentrations of hsCRP were significantly higher in CD than UC. Except for IL13, all cytokines and hsCRP positively correlated with CDAI. In UC, a positive correlation with MDAI was observed for hsCRP, GM-CSF, IL12(p70), and IFNγ and a negative one for IL8. The concentrations of hsCRP, GM-CSF, IFNγ, IL12(p70), and RANTES were higher in UC patients with active than inactive disease whereas those of IL8 and TNFα were significantly lower. Eotaxin, determined individually or in a panel with IFNγ and hsCRP, showed fair accuracy in differentiating CD from UC. If confirmed on a larger representation of IBS patients, IL8 might support differential diagnosis of organic and functional conditions of the bowel. GM-CSF, in turn, demonstrated to be an excellent indicator of bowel inflammation and may be taken into consideration as a noninvasive marker of mucosal healing. In summary, eosinophil-associated cytokines are elevated in IBD, more pronouncedly in UC, and may support the differential diagnosis of IBD and aid in monitoring of mucosal healing.http://dx.doi.org/10.1155/2018/7265812 |
| spellingShingle | Katarzyna Neubauer Malgorzata Matusiewicz Iwona Bednarz-Misa Sabina Gorska Andrzej Gamian Malgorzata Krzystek-Korpacka Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD Gastroenterology Research and Practice |
| title | Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD |
| title_full | Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD |
| title_fullStr | Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD |
| title_full_unstemmed | Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD |
| title_short | Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD |
| title_sort | diagnostic potential of systemic eosinophil associated cytokines and growth factors in ibd |
| url | http://dx.doi.org/10.1155/2018/7265812 |
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