Impact of acute respiratory distress syndrome on outcome in critically ill patients with liver cirrhosis
Abstract We investigated the occurrence and outcome of respiratory failure and ARDS in critically ill patients with liver cirrhosis. This is a retrospective analysis of patients with liver cirrhosis at an ICU during an 8-Year period. An assessment of acute on chronic liver failure as well as the pre...
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Nature Portfolio
2025-02-01
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| author | Pischtaz Adel Tariparast Kevin Roedl Thomas Horvatits Andreas Drolz Stefan Kluge Valentin Fuhrmann |
| author_facet | Pischtaz Adel Tariparast Kevin Roedl Thomas Horvatits Andreas Drolz Stefan Kluge Valentin Fuhrmann |
| author_sort | Pischtaz Adel Tariparast |
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| description | Abstract We investigated the occurrence and outcome of respiratory failure and ARDS in critically ill patients with liver cirrhosis. This is a retrospective analysis of patients with liver cirrhosis at an ICU during an 8-Year period. An assessment of acute on chronic liver failure as well as the presence and grade of ARDS within the first 72 h of admission to the ICU was performed. A total of 735 patients during the study period. Median age was 58 (50–69) years and 61% (n = 447) were male. 57% (n = 421) of the patients received mechanical ventilation (MV). Liver specific as well as ICU scores on admission were significantly higher in patients with MV. Necessity of vasopressor support (86%vs.25%, p < 0.001) and RRT (50%vs.11%, p < 0.001) was more frequent in patients with MV. The incidence of ARDS within the first 72 h of admission was 8% (n = 61). We observed a 28-day mortality or liver transplantation rate of 54% (n = 196) and 66% (n = 66%) in patients with MV and ARDS, respectively. After 90-days 63% (n = 226) with MV and 70% (n = 43) with ARDS were dead or received liver transplantation. ARDS is a prognostic factor for mortality in patients with liver cirrhosis admitted to the ICU. One out of ten critically ill cirrhotic patients develop ARDS within 72 h after admission. Although mortality rates are high initially critical care therapy should not be withheld and must be reevaluated regularly. |
| format | Article |
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| institution | Kabale University |
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| language | English |
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| spelling | doaj-art-cabcb7c8f73d413a9c4784a0511894702025-02-09T12:36:15ZengNature PortfolioScientific Reports2045-23222025-02-0115111010.1038/s41598-025-88606-zImpact of acute respiratory distress syndrome on outcome in critically ill patients with liver cirrhosisPischtaz Adel Tariparast0Kevin Roedl1Thomas Horvatits2Andreas Drolz3Stefan Kluge4Valentin Fuhrmann5Department of Intensive Care Medicine, University Medical Center Hamburg-EppendorfDepartment of Intensive Care Medicine, University Medical Center Hamburg-EppendorfDepartment of Medicine I, University Medical Center Hamburg-EppendorfDepartment of Medicine I, University Medical Center Hamburg-EppendorfDepartment of Intensive Care Medicine, University Medical Center Hamburg-EppendorfDepartment of Intensive Care Medicine, University Medical Center Hamburg-EppendorfAbstract We investigated the occurrence and outcome of respiratory failure and ARDS in critically ill patients with liver cirrhosis. This is a retrospective analysis of patients with liver cirrhosis at an ICU during an 8-Year period. An assessment of acute on chronic liver failure as well as the presence and grade of ARDS within the first 72 h of admission to the ICU was performed. A total of 735 patients during the study period. Median age was 58 (50–69) years and 61% (n = 447) were male. 57% (n = 421) of the patients received mechanical ventilation (MV). Liver specific as well as ICU scores on admission were significantly higher in patients with MV. Necessity of vasopressor support (86%vs.25%, p < 0.001) and RRT (50%vs.11%, p < 0.001) was more frequent in patients with MV. The incidence of ARDS within the first 72 h of admission was 8% (n = 61). We observed a 28-day mortality or liver transplantation rate of 54% (n = 196) and 66% (n = 66%) in patients with MV and ARDS, respectively. After 90-days 63% (n = 226) with MV and 70% (n = 43) with ARDS were dead or received liver transplantation. ARDS is a prognostic factor for mortality in patients with liver cirrhosis admitted to the ICU. One out of ten critically ill cirrhotic patients develop ARDS within 72 h after admission. Although mortality rates are high initially critical care therapy should not be withheld and must be reevaluated regularly.https://doi.org/10.1038/s41598-025-88606-zLiver cirrhosisAcute-on-chronic liver failureMultiple organ failureIntensive care unitAcute liver failureARDS |
| spellingShingle | Pischtaz Adel Tariparast Kevin Roedl Thomas Horvatits Andreas Drolz Stefan Kluge Valentin Fuhrmann Impact of acute respiratory distress syndrome on outcome in critically ill patients with liver cirrhosis Scientific Reports Liver cirrhosis Acute-on-chronic liver failure Multiple organ failure Intensive care unit Acute liver failure ARDS |
| title | Impact of acute respiratory distress syndrome on outcome in critically ill patients with liver cirrhosis |
| title_full | Impact of acute respiratory distress syndrome on outcome in critically ill patients with liver cirrhosis |
| title_fullStr | Impact of acute respiratory distress syndrome on outcome in critically ill patients with liver cirrhosis |
| title_full_unstemmed | Impact of acute respiratory distress syndrome on outcome in critically ill patients with liver cirrhosis |
| title_short | Impact of acute respiratory distress syndrome on outcome in critically ill patients with liver cirrhosis |
| title_sort | impact of acute respiratory distress syndrome on outcome in critically ill patients with liver cirrhosis |
| topic | Liver cirrhosis Acute-on-chronic liver failure Multiple organ failure Intensive care unit Acute liver failure ARDS |
| url | https://doi.org/10.1038/s41598-025-88606-z |
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