Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts

Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts

IntroductionBurkitt Lymphoma (BL), an aggressive B-cell lymphoma driven by MYC translocations, requires intensive chemotherapy treatments which deliver high effectiveness yet increase future risks of developing secondary malignancies. We have previously shown that DDX3X, an RNA helicase frequently m...

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Bibliographic Details
Main Authors: Hugues Beauchemin, Zeinab Dalloul, Eva-Maria Piskor, Virginie Calderon, Andrew Chatr-aryamontri, Thierry Bertomeu, Tarik Möröy
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
RNA helicase
DDX3 as a potential target
Burkitt lymphoma (BL)
DDX3 inhibitor
xenograft
ATP-dependent RNA helicase
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1642006/full
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