Loading and Skeletal Development and Maintenance
Mechanical loading is a major regulator of bone mass and geometry. The osteocytes network is considered the main sensor of loads, through the shear stress generated by strain induced fluid flow in the lacuno-canalicular system. Intracellular transduction implies several kinases and phosphorylation o...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.4061/2011/786752 |
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| _version_ | 1832568029481795584 |
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| author | P. Bergmann J. J. Body S. Boonen Y. Boutsen J. P. Devogelaer S. Goemaere J. Kaufman J. Y. Reginster S. Rozenberg |
| author_facet | P. Bergmann J. J. Body S. Boonen Y. Boutsen J. P. Devogelaer S. Goemaere J. Kaufman J. Y. Reginster S. Rozenberg |
| author_sort | P. Bergmann |
| collection | DOAJ |
| description | Mechanical loading is a major regulator of bone mass and geometry. The osteocytes network is considered the main sensor of loads, through the shear stress generated by strain induced fluid flow in the lacuno-canalicular system. Intracellular transduction implies several kinases and phosphorylation of the estrogen receptor. Several extra-cellular mediators, among which NO and prostaglandins are transducing the signal to the effector cells. Disuse results in osteocytes apoptosis and rapid imbalanced bone resorption, leading to severe osteoporosis. Exercising during growth increases peak bone mass, and could be beneficial with regards to osteoporosis later in life, but the gain could be lost if training is abandoned. Exercise programs in adults and seniors have barely significant effects on bone mass and geometry at least at short term. There are few data on a possible additive effect of exercise and drugs in osteoporosis treatment, but disuse could decrease drugs action. Exercise programs proposed for bone health are tedious and compliance is usually low. The most practical advice for patients is to walk a minimum of 30 to 60 minutes per day. Other exercises like swimming or cycling have less effect on bone, but could reduce fracture risk indirectly by maintaining muscle mass and force. |
| format | Article |
| id | doaj-art-cab7f73f5c134ce993765a51182dc371 |
| institution | Kabale University |
| issn | 2042-0064 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-cab7f73f5c134ce993765a51182dc3712025-02-03T00:59:52ZengWileyJournal of Osteoporosis2042-00642011-01-01201110.4061/2011/786752786752Loading and Skeletal Development and MaintenanceP. Bergmann0J. J. Body1S. Boonen2Y. Boutsen3J. P. Devogelaer4S. Goemaere5J. Kaufman6J. Y. Reginster7S. Rozenberg8Department of Nuclear Medicine, Laboratory of Clinical Chemistry and Experimental Medicine, CHU Brugmann, Université Libre de Bruxelles, 4 Pl. Van Gehuchten, 1020 Brussels, BelgiumDepartment of Medicine, CHU Brugmann, Université Libre de Bruxelles, 1020 Brussels, BelgiumDivision of Gerontology and Geriatrics, Center for Musculoskeletal Research, Department of Experimental Medicine, Catholic Leuven University, 3000 Leuven, BelgiumDepartment of Rheumatology, Mont-Godinne University Hospital, Université Catholique de Louvain, 1200 Brussels, BelgiumRheumatology Unit, Saint-Luc University Hospital, Université Catholique de Louvain, 1200 Brussels, BelgiumUnit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, 9000 Ghent, BelgiumUnit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, 9000 Ghent, BelgiumDepartment of Public Health Sciences, University of Liège, 4000 Liège, BelgiumDepartment of Gynaecology-Obstetrics, Free University of Brussels, 1090 Brussels, BelgiumMechanical loading is a major regulator of bone mass and geometry. The osteocytes network is considered the main sensor of loads, through the shear stress generated by strain induced fluid flow in the lacuno-canalicular system. Intracellular transduction implies several kinases and phosphorylation of the estrogen receptor. Several extra-cellular mediators, among which NO and prostaglandins are transducing the signal to the effector cells. Disuse results in osteocytes apoptosis and rapid imbalanced bone resorption, leading to severe osteoporosis. Exercising during growth increases peak bone mass, and could be beneficial with regards to osteoporosis later in life, but the gain could be lost if training is abandoned. Exercise programs in adults and seniors have barely significant effects on bone mass and geometry at least at short term. There are few data on a possible additive effect of exercise and drugs in osteoporosis treatment, but disuse could decrease drugs action. Exercise programs proposed for bone health are tedious and compliance is usually low. The most practical advice for patients is to walk a minimum of 30 to 60 minutes per day. Other exercises like swimming or cycling have less effect on bone, but could reduce fracture risk indirectly by maintaining muscle mass and force.http://dx.doi.org/10.4061/2011/786752 |
| spellingShingle | P. Bergmann J. J. Body S. Boonen Y. Boutsen J. P. Devogelaer S. Goemaere J. Kaufman J. Y. Reginster S. Rozenberg Loading and Skeletal Development and Maintenance Journal of Osteoporosis |
| title | Loading and Skeletal Development and Maintenance |
| title_full | Loading and Skeletal Development and Maintenance |
| title_fullStr | Loading and Skeletal Development and Maintenance |
| title_full_unstemmed | Loading and Skeletal Development and Maintenance |
| title_short | Loading and Skeletal Development and Maintenance |
| title_sort | loading and skeletal development and maintenance |
| url | http://dx.doi.org/10.4061/2011/786752 |
| work_keys_str_mv | AT pbergmann loadingandskeletaldevelopmentandmaintenance AT jjbody loadingandskeletaldevelopmentandmaintenance AT sboonen loadingandskeletaldevelopmentandmaintenance AT yboutsen loadingandskeletaldevelopmentandmaintenance AT jpdevogelaer loadingandskeletaldevelopmentandmaintenance AT sgoemaere loadingandskeletaldevelopmentandmaintenance AT jkaufman loadingandskeletaldevelopmentandmaintenance AT jyreginster loadingandskeletaldevelopmentandmaintenance AT srozenberg loadingandskeletaldevelopmentandmaintenance |