Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice

Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice

Background and Aims: Entecavir (ETV) resistance of hepatitis B virus (HBV) conventionally requires rt184, 202, or 250 mutations plus lamivudine-resistance mutation (rtM204V/I ± L180M). This study aimed to clarify whether rtL180M+A181C+M204V mutations may contribute to HBV ETV resistance.Methods: Ser...

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Main Authors: Yan Liu, Yi Zhou, Xiaodong Li, Ming Niu, Rongjuan Chen, Jinman Shao, Lanlan Si, Dan Luo, Yayun Lin, Le Li, Kai Zhang, Xiaohe Xiao, Zhihui Xu, Min Liu, Mengji Lu, Fabien Zoulim, Dongping Xu
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
Hepatitis B virus
nucleoside/nucleotide analogues
entecavir resistance
mutation
rtA181C
antiviral therapy
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1584018
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