Biopharmaceutical Characterization and Stability of Nabumetone–Cyclodextrins Complexes Prepared by Grinding

Biopharmaceutical Characterization and Stability of Nabumetone–Cyclodextrins Complexes Prepared by Grinding

<b>Background:</b> Nabumetone (NAB) is a poorly soluble nonsteroidal anti-inflammatory prodrug (BCS class II drug) whose solubility is significantly improved by complexation with cyclodextrins (CDs). <b>Methods</b>: The solid complexes, in a 1:1 molar ratio, were prepared by...

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Bibliographic Details
Main Authors: David Klarić, Željka Soldin, Anna Vincze, Rita Szolláth, György Tibor Balogh, Mario Jug, Nives Galić
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceutics
Subjects:
nabumetone
cyclodextrins
mechanochemistry
solid-state characterization
in vitro permeability
in vitro dissolution
Online Access:https://www.mdpi.com/1999-4923/16/12/1493
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