DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells

DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells

IntroductionThe functionalization of nanoparticles (NPs) with an antiCD19 targeting mechanism represents a promising approach for the selective delivery of drugs and nucleic acids into normal and tumor B cells. This strategy has the advantage of minimizing off-target effects by restricting gene deli...

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Main Authors: Maria Cristina Grimaldi, Sara Bozzer, Dick J. Sjöström, Linnea I. Andersson, Tom Eirik Mollnes, Per H. Nilsson, Luca De Maso, Federico Riccardi, Michele Dal Bo, Daniele Sblattero, Paolo Macor
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
polymeric nanoparticles
targeting
safety
in vivo transfection
zebrafish
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1509322/full
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