A or AB? Resolving the dilemma of weaker subgroup through serological evaluation: Reporting two cases from Uttarakhand
Blood group discrepancies and their resolution can sometimes become tricky when it comes to weaker subgroups. A number of weaker B subgroups, which are very infrequently encountered, have been described, including B3, Bx, Bm, and Bel. The varied serologic reactivity of these subgroups, using routine...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Asian Journal of Transfusion Science |
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| Online Access: | https://journals.lww.com/10.4103/ajts.ajts_154_23 |
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| author | Vaidehi Prasanth Pradip Banerjee Daljit Kaur Dixa Kumari Chanchi B. Khiamniungan Juhi Bhatia Ashish Jain Gita Negi |
| author_facet | Vaidehi Prasanth Pradip Banerjee Daljit Kaur Dixa Kumari Chanchi B. Khiamniungan Juhi Bhatia Ashish Jain Gita Negi |
| author_sort | Vaidehi Prasanth |
| collection | DOAJ |
| description | Blood group discrepancies and their resolution can sometimes become tricky when it comes to weaker subgroups. A number of weaker B subgroups, which are very infrequently encountered, have been described, including B3, Bx, Bm, and Bel. The varied serologic reactivity of these subgroups, using routine human polyclonal antisera, usually startles the personnel involved in such blood group discrepancies and interpretation is either delayed or incorrect. Here, we present two cases of AB Rh (D) positive with weak B subgroups, detected in two whole blood donors. Their red cells showed strong agglutination with anti-A, anti-AB, and anti-D, no reaction with anti-B, and serum showed no reaction with A1, A2, B, and O cells. Adsorption-elution procedure and salivary testing suggested the presence of a weaker B subgroup (Bel). Hence, ABel subgroup was reported for both the donors. Resolution of blood group discrepancies is crucial, as it would aid to prevent hemolytic transfusion reactions due to inaccurate blood group interpretation. |
| format | Article |
| id | doaj-art-caad528001194cfa81adad660a4b41eb |
| institution | Kabale University |
| issn | 0973-6247 1998-3565 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj-art-caad528001194cfa81adad660a4b41eb2025-08-20T03:39:15ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652025-07-0119115415710.4103/ajts.ajts_154_23A or AB? Resolving the dilemma of weaker subgroup through serological evaluation: Reporting two cases from UttarakhandVaidehi PrasanthPradip BanerjeeDaljit KaurDixa KumariChanchi B. KhiamniunganJuhi BhatiaAshish JainGita NegiBlood group discrepancies and their resolution can sometimes become tricky when it comes to weaker subgroups. A number of weaker B subgroups, which are very infrequently encountered, have been described, including B3, Bx, Bm, and Bel. The varied serologic reactivity of these subgroups, using routine human polyclonal antisera, usually startles the personnel involved in such blood group discrepancies and interpretation is either delayed or incorrect. Here, we present two cases of AB Rh (D) positive with weak B subgroups, detected in two whole blood donors. Their red cells showed strong agglutination with anti-A, anti-AB, and anti-D, no reaction with anti-B, and serum showed no reaction with A1, A2, B, and O cells. Adsorption-elution procedure and salivary testing suggested the presence of a weaker B subgroup (Bel). Hence, ABel subgroup was reported for both the donors. Resolution of blood group discrepancies is crucial, as it would aid to prevent hemolytic transfusion reactions due to inaccurate blood group interpretation.https://journals.lww.com/10.4103/ajts.ajts_154_23blood group discrepancyelutionsaliva testingweak subgroup |
| spellingShingle | Vaidehi Prasanth Pradip Banerjee Daljit Kaur Dixa Kumari Chanchi B. Khiamniungan Juhi Bhatia Ashish Jain Gita Negi A or AB? Resolving the dilemma of weaker subgroup through serological evaluation: Reporting two cases from Uttarakhand Asian Journal of Transfusion Science blood group discrepancy elution saliva testing weak subgroup |
| title | A or AB? Resolving the dilemma of weaker subgroup through serological evaluation: Reporting two cases from Uttarakhand |
| title_full | A or AB? Resolving the dilemma of weaker subgroup through serological evaluation: Reporting two cases from Uttarakhand |
| title_fullStr | A or AB? Resolving the dilemma of weaker subgroup through serological evaluation: Reporting two cases from Uttarakhand |
| title_full_unstemmed | A or AB? Resolving the dilemma of weaker subgroup through serological evaluation: Reporting two cases from Uttarakhand |
| title_short | A or AB? Resolving the dilemma of weaker subgroup through serological evaluation: Reporting two cases from Uttarakhand |
| title_sort | or ab resolving the dilemma of weaker subgroup through serological evaluation reporting two cases from uttarakhand |
| topic | blood group discrepancy elution saliva testing weak subgroup |
| url | https://journals.lww.com/10.4103/ajts.ajts_154_23 |
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