A Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with <i>Klebsiella pneumoniae</i>: Analyzing a Dataset from a Romanian Tertiary Hospital
<b>Introduction:</b> The emergence of carbapenem-resistant pathogenic bacteria is a growing global public health concern. Carbapenem-resistant uropathogenic strains of <i>Klebsiella pneumoniae</i> can cause uncomplicated or complicated urinary tract infections, leading to a h...
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2024-12-01
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| author | Dragos Stefan Lazar Maria Nica Daniel Romeo Codreanu Alma Gabriela Kosa Lucian L. Visinescu Corneliu Petru Popescu Ion Cristian Efrem Simin Aysel Florescu George Sebastian Gherlan |
| author_facet | Dragos Stefan Lazar Maria Nica Daniel Romeo Codreanu Alma Gabriela Kosa Lucian L. Visinescu Corneliu Petru Popescu Ion Cristian Efrem Simin Aysel Florescu George Sebastian Gherlan |
| author_sort | Dragos Stefan Lazar |
| collection | DOAJ |
| description | <b>Introduction:</b> The emergence of carbapenem-resistant pathogenic bacteria is a growing global public health concern. Carbapenem-resistant uropathogenic strains of <i>Klebsiella pneumoniae</i> can cause uncomplicated or complicated urinary tract infections, leading to a high risk of treatment failure and the spread of resistance determinants. The objectives of this 24-month study were to identify the prognostic characteristics of patients who were infected with carbapenem-resistant <i>Klebsiella pneumoniae</i> (<i>CRKpn</i>) and to create a tool to estimate the probability of a <i>CRKpn</i> infection before having the complete results of a patient’s antibiogram. <b>Results:</b> We found that 41.6% of all urinary infections with <i>Kpn</i> were caused by <i>CRKpn</i>. Factors such as male gender, the presence of upper urinary tract infections, invasive urinary maneuvers, recent infection with or carriage of the germ, and the nosocomial occurrence of UTIs with <i>Kpn</i> were predictive for <i>CRKpn</i> infection. Based on these factors, we proposed a model to estimate the presence of <i>CRKpn</i>. <b>Methods:</b> A retrospective case–control study including all hospitalized patients with urinary tract infections (UTIs) caused by <i>Klebsiella pneumoniae</i> was carried out. We reported data as percentages, identified independent predictors of the presence of <i>CRKpn</i>, and proposed a tool to evaluate the probability through multivariate analysis. <b>Conclusions:</b> Through this study, we aim to provide clinicians with a tool to support decision making regarding first-line antibiotic treatment. |
| format | Article |
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| institution | OA Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-caaa31e9852f4cb19459076bc3c3020c2025-08-20T02:01:05ZengMDPI AGAntibiotics2079-63822024-12-011312117010.3390/antibiotics13121170A Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with <i>Klebsiella pneumoniae</i>: Analyzing a Dataset from a Romanian Tertiary HospitalDragos Stefan Lazar0Maria Nica1Daniel Romeo Codreanu2Alma Gabriela Kosa3Lucian L. Visinescu4Corneliu Petru Popescu5Ion Cristian Efrem6Simin Aysel Florescu7George Sebastian Gherlan8“Dr Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, “Carol Davila” University of Medicine and Pharmacy, 030303 Bucharest, Romania“Dr Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, “Carol Davila” University of Medicine and Pharmacy, 030303 Bucharest, Romania“Dr Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, “Carol Davila” University of Medicine and Pharmacy, 030303 Bucharest, Romania“Dr Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, “Carol Davila” University of Medicine and Pharmacy, 030303 Bucharest, RomaniaDepartment of Information Systems & Analytics Austin, Texas State University, San Marcos, TX 78666, USA“Dr Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, “Carol Davila” University of Medicine and Pharmacy, 030303 Bucharest, RomaniaInternal Medicine Department, Craiova University of Medicine and Pharmacy, 200349 Craiova, Romania“Dr Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, “Carol Davila” University of Medicine and Pharmacy, 030303 Bucharest, Romania“Dr Victor Babes” Clinical Hospital of Infectious and Tropical Diseases, “Carol Davila” University of Medicine and Pharmacy, 030303 Bucharest, Romania<b>Introduction:</b> The emergence of carbapenem-resistant pathogenic bacteria is a growing global public health concern. Carbapenem-resistant uropathogenic strains of <i>Klebsiella pneumoniae</i> can cause uncomplicated or complicated urinary tract infections, leading to a high risk of treatment failure and the spread of resistance determinants. The objectives of this 24-month study were to identify the prognostic characteristics of patients who were infected with carbapenem-resistant <i>Klebsiella pneumoniae</i> (<i>CRKpn</i>) and to create a tool to estimate the probability of a <i>CRKpn</i> infection before having the complete results of a patient’s antibiogram. <b>Results:</b> We found that 41.6% of all urinary infections with <i>Kpn</i> were caused by <i>CRKpn</i>. Factors such as male gender, the presence of upper urinary tract infections, invasive urinary maneuvers, recent infection with or carriage of the germ, and the nosocomial occurrence of UTIs with <i>Kpn</i> were predictive for <i>CRKpn</i> infection. Based on these factors, we proposed a model to estimate the presence of <i>CRKpn</i>. <b>Methods:</b> A retrospective case–control study including all hospitalized patients with urinary tract infections (UTIs) caused by <i>Klebsiella pneumoniae</i> was carried out. We reported data as percentages, identified independent predictors of the presence of <i>CRKpn</i>, and proposed a tool to evaluate the probability through multivariate analysis. <b>Conclusions:</b> Through this study, we aim to provide clinicians with a tool to support decision making regarding first-line antibiotic treatment.https://www.mdpi.com/2079-6382/13/12/1170carbapenem-resistant <i>Klebsiella pneumoniae</i>urinary tract infectionrisk estimation toolcarbapenemasesantibiotic therapy |
| spellingShingle | Dragos Stefan Lazar Maria Nica Daniel Romeo Codreanu Alma Gabriela Kosa Lucian L. Visinescu Corneliu Petru Popescu Ion Cristian Efrem Simin Aysel Florescu George Sebastian Gherlan A Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with <i>Klebsiella pneumoniae</i>: Analyzing a Dataset from a Romanian Tertiary Hospital Antibiotics carbapenem-resistant <i>Klebsiella pneumoniae</i> urinary tract infection risk estimation tool carbapenemases antibiotic therapy |
| title | A Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with <i>Klebsiella pneumoniae</i>: Analyzing a Dataset from a Romanian Tertiary Hospital |
| title_full | A Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with <i>Klebsiella pneumoniae</i>: Analyzing a Dataset from a Romanian Tertiary Hospital |
| title_fullStr | A Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with <i>Klebsiella pneumoniae</i>: Analyzing a Dataset from a Romanian Tertiary Hospital |
| title_full_unstemmed | A Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with <i>Klebsiella pneumoniae</i>: Analyzing a Dataset from a Romanian Tertiary Hospital |
| title_short | A Possible Tool for Guiding Therapeutic Approaches to Urinary Infections with <i>Klebsiella pneumoniae</i>: Analyzing a Dataset from a Romanian Tertiary Hospital |
| title_sort | possible tool for guiding therapeutic approaches to urinary infections with i klebsiella pneumoniae i analyzing a dataset from a romanian tertiary hospital |
| topic | carbapenem-resistant <i>Klebsiella pneumoniae</i> urinary tract infection risk estimation tool carbapenemases antibiotic therapy |
| url | https://www.mdpi.com/2079-6382/13/12/1170 |
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