Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study
Objective. This study was performed to evaluate the efficacy and safety of a prebiotic treatment in the balance recovery of the vaginal flora in subjects previously treated for bacterial vaginosis (BV). Study Design. A randomized trial was carried out on 42 subjects with an active prebiotic group co...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2012/147867 |
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| author | Isabelle Coste Philippe Judlin Jean-Pierre Lepargneur Sami Bou-Antoun |
| author_facet | Isabelle Coste Philippe Judlin Jean-Pierre Lepargneur Sami Bou-Antoun |
| author_sort | Isabelle Coste |
| collection | DOAJ |
| description | Objective. This study was performed to evaluate the efficacy and safety of a prebiotic treatment in the balance recovery of the vaginal flora in subjects previously treated for bacterial vaginosis (BV). Study Design. A randomized trial was carried out on 42 subjects with an active prebiotic group compared to a placebo group. The main evaluation criterion was the quantification of the vaginal flora measured by the Nugent score. Secondary criteria included vaginal pH and BV recurrence. Results. After 8 days of treatment, all subjects who received the prebiotic had a normal Nugent score, whereas 33% of the subjects treated with placebo had an intermediate or positive Nugent score. After 16 days of application, a normal Nugent score was maintained in all subjects treated with the prebiotic, whereas in the placebo group 24% of the subjects still had an elevated Nugent score. Moreover, the maintenance of (or reversion to) a normal flora was associated with the maintenance of (or reversion to) physiological pH values. Conclusions. The intravaginal gel treatment improves the recovery of a normal vaginal flora after the treatment of a BV episode, which should warrant a reduction in the risk of further recurrences. |
| format | Article |
| id | doaj-art-caa92fc01a014ca593cc363332548849 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-caa92fc01a014ca593cc3633325488492025-02-03T01:02:29ZengWileyObstetrics and Gynecology International1687-95891687-95972012-01-01201210.1155/2012/147867147867Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind StudyIsabelle Coste0Philippe Judlin1Jean-Pierre Lepargneur2Sami Bou-Antoun3Alliospharma, 1 Allée des Ecureuils, 69380 Lissieu, FranceDepartment of Obstetrics, Gynecology & Reproduction, Maternité Régionale Universitaire, 10 rue du Dr Heydenreich, 54042 Nancy, FranceNovescia, 29 rue de la bienfaisance, 75008 Paris, FranceAlliospharma, 1 Allée des Ecureuils, 69380 Lissieu, FranceObjective. This study was performed to evaluate the efficacy and safety of a prebiotic treatment in the balance recovery of the vaginal flora in subjects previously treated for bacterial vaginosis (BV). Study Design. A randomized trial was carried out on 42 subjects with an active prebiotic group compared to a placebo group. The main evaluation criterion was the quantification of the vaginal flora measured by the Nugent score. Secondary criteria included vaginal pH and BV recurrence. Results. After 8 days of treatment, all subjects who received the prebiotic had a normal Nugent score, whereas 33% of the subjects treated with placebo had an intermediate or positive Nugent score. After 16 days of application, a normal Nugent score was maintained in all subjects treated with the prebiotic, whereas in the placebo group 24% of the subjects still had an elevated Nugent score. Moreover, the maintenance of (or reversion to) a normal flora was associated with the maintenance of (or reversion to) physiological pH values. Conclusions. The intravaginal gel treatment improves the recovery of a normal vaginal flora after the treatment of a BV episode, which should warrant a reduction in the risk of further recurrences.http://dx.doi.org/10.1155/2012/147867 |
| spellingShingle | Isabelle Coste Philippe Judlin Jean-Pierre Lepargneur Sami Bou-Antoun Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study Obstetrics and Gynecology International |
| title | Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study |
| title_full | Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study |
| title_fullStr | Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study |
| title_full_unstemmed | Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study |
| title_short | Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study |
| title_sort | safety and efficacy of an intravaginal prebiotic gel in the prevention of recurrent bacterial vaginosis a randomized double blind study |
| url | http://dx.doi.org/10.1155/2012/147867 |
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