Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice

Accumulating evidence revealed that some probiotics regulated lipid metabolism and alleviated diet-induced non-alcoholic fatty liver disease (NAFLD). This study mainly explored whether yogurt-derived Lactobacillus plantarum Q16 modulated lipid and energy metabolism, and suppressed microbial dysbiosi...

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Main Authors: Chao Tang, Weiwei Zhou, Mengyuan Shan, Zhaoxin Lu, Yingjian Lu
Format: Article
Language:English
Published: Tsinghua University Press 2022-09-01
Series:Food Science and Human Wellness
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213453022000726
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author Chao Tang
Weiwei Zhou
Mengyuan Shan
Zhaoxin Lu
Yingjian Lu
author_facet Chao Tang
Weiwei Zhou
Mengyuan Shan
Zhaoxin Lu
Yingjian Lu
author_sort Chao Tang
collection DOAJ
description Accumulating evidence revealed that some probiotics regulated lipid metabolism and alleviated diet-induced non-alcoholic fatty liver disease (NAFLD). This study mainly explored whether yogurt-derived Lactobacillus plantarum Q16 modulated lipid and energy metabolism, and suppressed microbial dysbiosis in high-fat diet (HFD)-fed mice. Results showed that oral administration of L. plantarum Q16 improved serum and hepatic lipid profile. Protein analysis showed that L. plantarum Q16 could reduce hepatic lipid content by reducing the expression of FAS, ACC, SCD-1, Srebp-1c and ATGL, but increasing expression levels of CPT-1α, PPAR-α and ATGL. Meanwhile, L. plantarum Q16 also improved hepatic energy metabolism by regulating FGF21/adiponectin/AMPKα/PGC-1α signaling pathway. Metagenomic analysis also discovered that L. plantarum Q16 increased species diversity and richness of intestinal microbiota, promoted proliferation of beneficial commensals and suppressed the growth of endotoxin-producing microorganisms in the colon of HFD-fed mice. Overall, L. plantarum Q16 protected against HFD-induced NAFLD by improving hepatic profile and regulating colonic microbiota composition.
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spelling doaj-art-caa3911932a740f497aff437c72de7f82025-02-03T06:15:29ZengTsinghua University PressFood Science and Human Wellness2213-45302022-09-0111514281439Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in miceChao Tang0Weiwei Zhou1Mengyuan Shan2Zhaoxin Lu3Yingjian Lu4College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China; Corresponding authors. Fax: 0086-25-84396583College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210023, China; Corresponding authors. Fax: 0086-25-84396583Accumulating evidence revealed that some probiotics regulated lipid metabolism and alleviated diet-induced non-alcoholic fatty liver disease (NAFLD). This study mainly explored whether yogurt-derived Lactobacillus plantarum Q16 modulated lipid and energy metabolism, and suppressed microbial dysbiosis in high-fat diet (HFD)-fed mice. Results showed that oral administration of L. plantarum Q16 improved serum and hepatic lipid profile. Protein analysis showed that L. plantarum Q16 could reduce hepatic lipid content by reducing the expression of FAS, ACC, SCD-1, Srebp-1c and ATGL, but increasing expression levels of CPT-1α, PPAR-α and ATGL. Meanwhile, L. plantarum Q16 also improved hepatic energy metabolism by regulating FGF21/adiponectin/AMPKα/PGC-1α signaling pathway. Metagenomic analysis also discovered that L. plantarum Q16 increased species diversity and richness of intestinal microbiota, promoted proliferation of beneficial commensals and suppressed the growth of endotoxin-producing microorganisms in the colon of HFD-fed mice. Overall, L. plantarum Q16 protected against HFD-induced NAFLD by improving hepatic profile and regulating colonic microbiota composition.http://www.sciencedirect.com/science/article/pii/S2213453022000726Lactobacillus plantarum Q16Non-alcoholic fatty acid liver diseaseLipid metabolismEnergy metabolismColonic microbiota
spellingShingle Chao Tang
Weiwei Zhou
Mengyuan Shan
Zhaoxin Lu
Yingjian Lu
Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice
Food Science and Human Wellness
Lactobacillus plantarum Q16
Non-alcoholic fatty acid liver disease
Lipid metabolism
Energy metabolism
Colonic microbiota
title Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice
title_full Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice
title_fullStr Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice
title_full_unstemmed Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice
title_short Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice
title_sort yogurt derived lactobacillus plantarum q16 alleviated high fat diet induced non alcoholic fatty liver disease in mice
topic Lactobacillus plantarum Q16
Non-alcoholic fatty acid liver disease
Lipid metabolism
Energy metabolism
Colonic microbiota
url http://www.sciencedirect.com/science/article/pii/S2213453022000726
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