Transcriptomic Analysis of Tambaqui (<i>Colossoma macropomum</i>) Exposed to Trichlorfon-Induced Toxicity
Trichlorfon is an antiparasitic agent widely used to control pests and parasites in farmed fish. Tambaqui (<i>C. macropomum</i>) is the most commercially important characid species farmed in the Amazon region. Trichlorfon exposure is known to cause physiological damage in fish due to its...
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MDPI AG
2025-06-01
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| Online Access: | https://www.mdpi.com/2076-2615/15/12/1807 |
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| author | Hallana Cristina Menezes da Silva Igor Kelvyn Cavalcante Lobo André Gentil da Silva Ana Lúcia Silva Gomes Wallice Paxiúba Duncan Juliana Costa Silva Fabrício M. Lopes Roberto Ferreira Artoni Daniele Aparecida Matoso |
| author_facet | Hallana Cristina Menezes da Silva Igor Kelvyn Cavalcante Lobo André Gentil da Silva Ana Lúcia Silva Gomes Wallice Paxiúba Duncan Juliana Costa Silva Fabrício M. Lopes Roberto Ferreira Artoni Daniele Aparecida Matoso |
| author_sort | Hallana Cristina Menezes da Silva |
| collection | DOAJ |
| description | Trichlorfon is an antiparasitic agent widely used to control pests and parasites in farmed fish. Tambaqui (<i>C. macropomum</i>) is the most commercially important characid species farmed in the Amazon region. Trichlorfon exposure is known to cause physiological damage in fish due to its organophosphate nature. In this study, we used RNA-Seq to investigate the hepatic response of tambaqui following exposure to 0.435 mg/L of trichlorfon. The analysis revealed activation of several metabolic pathways, particularly those related to tumor processes, immune responses, and apoptosis. Additionally, we identified upregulation of solute carrier (SLC) genes, which may facilitate trichlorfon entry into hepatocytes. These findings enhance our understanding of fish responses to antiparasitic agents and support further research into the molecular impacts of organophosphate compounds in aquaculture species. |
| format | Article |
| id | doaj-art-caa2ddfa495c4cf1b9145e31443e7d17 |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-caa2ddfa495c4cf1b9145e31443e7d172025-08-20T03:32:28ZengMDPI AGAnimals2076-26152025-06-011512180710.3390/ani15121807Transcriptomic Analysis of Tambaqui (<i>Colossoma macropomum</i>) Exposed to Trichlorfon-Induced ToxicityHallana Cristina Menezes da Silva0Igor Kelvyn Cavalcante Lobo1André Gentil da Silva2Ana Lúcia Silva Gomes3Wallice Paxiúba Duncan4Juliana Costa Silva5Fabrício M. Lopes6Roberto Ferreira Artoni7Daniele Aparecida Matoso8Programa de Pós-Graduação em Genética, Conservação e Biologia Evolutiva, Instituto Nacional de Pesquisas da Amazônia, Manaus 69067-375, AM, BrazilPrograma de Pós-Graduação em Genética, Laboratório de Algoritmos em Biologia, Universidade Federal de Minas Gerais, Belo-Horizonte 31270-800, MG, BrazilLaboratório de Parasitologia de Animais Aquáticos, Universidade Federal do Amazonas, Manaus 69067-005, AM, BrazilLaboratório de Parasitologia de Animais Aquáticos, Departamento de Parasitologia, Universidade Federal do Amazonas, Manaus 69067-005, AM, BrazilLaboratório de Morfologia Funcional, Departamento de Morfologia, Universidade Federal do Amazonas, Manaus 69067-005, AM, BrazilDepartamento de Informática, Universidade Federal do Paraná, Curitiba 81531-990, PR, BrazilPrograma de Pós-Graduação em Bioinformática, Departamento Acadêmico de Computação, Universidade Tecnológica Federal do Paraná, Cornélio Procópio 86300-000, PR, BrazilLaboratório de Genética e Evolução, Departamento de Biologia Estrutural, Molecular e Genética, Universidade Estadual de Ponta Grossa, Ponta Grossa 84010-330, PR, BrazilLaboratório de Biotecnologia e Citogenômica Animal, Departamento de Genética, Universidade Federal do Amazonas, Manaus 69067-005, AM, BrazilTrichlorfon is an antiparasitic agent widely used to control pests and parasites in farmed fish. Tambaqui (<i>C. macropomum</i>) is the most commercially important characid species farmed in the Amazon region. Trichlorfon exposure is known to cause physiological damage in fish due to its organophosphate nature. In this study, we used RNA-Seq to investigate the hepatic response of tambaqui following exposure to 0.435 mg/L of trichlorfon. The analysis revealed activation of several metabolic pathways, particularly those related to tumor processes, immune responses, and apoptosis. Additionally, we identified upregulation of solute carrier (SLC) genes, which may facilitate trichlorfon entry into hepatocytes. These findings enhance our understanding of fish responses to antiparasitic agents and support further research into the molecular impacts of organophosphate compounds in aquaculture species.https://www.mdpi.com/2076-2615/15/12/1807toxicologytrichlorfonfresh water<i>C. macropomum</i> |
| spellingShingle | Hallana Cristina Menezes da Silva Igor Kelvyn Cavalcante Lobo André Gentil da Silva Ana Lúcia Silva Gomes Wallice Paxiúba Duncan Juliana Costa Silva Fabrício M. Lopes Roberto Ferreira Artoni Daniele Aparecida Matoso Transcriptomic Analysis of Tambaqui (<i>Colossoma macropomum</i>) Exposed to Trichlorfon-Induced Toxicity Animals toxicology trichlorfon fresh water <i>C. macropomum</i> |
| title | Transcriptomic Analysis of Tambaqui (<i>Colossoma macropomum</i>) Exposed to Trichlorfon-Induced Toxicity |
| title_full | Transcriptomic Analysis of Tambaqui (<i>Colossoma macropomum</i>) Exposed to Trichlorfon-Induced Toxicity |
| title_fullStr | Transcriptomic Analysis of Tambaqui (<i>Colossoma macropomum</i>) Exposed to Trichlorfon-Induced Toxicity |
| title_full_unstemmed | Transcriptomic Analysis of Tambaqui (<i>Colossoma macropomum</i>) Exposed to Trichlorfon-Induced Toxicity |
| title_short | Transcriptomic Analysis of Tambaqui (<i>Colossoma macropomum</i>) Exposed to Trichlorfon-Induced Toxicity |
| title_sort | transcriptomic analysis of tambaqui i colossoma macropomum i exposed to trichlorfon induced toxicity |
| topic | toxicology trichlorfon fresh water <i>C. macropomum</i> |
| url | https://www.mdpi.com/2076-2615/15/12/1807 |
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