Mathematical evaluation of hemolysis in a channel centrifugal blood pump
The objective of this work is to conduct research on a mathematical model to assess hemolytic characteristics in a channel centrifugal blood pump developed by us with 2000–3400 rpm impeller speed range and 100–250 mmHg pressure drop in different parts of the pump flow path. Hemolysis index was measu...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2020-10-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/1230 |
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| author | A. P. Kuleshov G. P. Itkin A. S. Buchnev A. A. Drobyshev |
| author_facet | A. P. Kuleshov G. P. Itkin A. S. Buchnev A. A. Drobyshev |
| author_sort | A. P. Kuleshov |
| collection | DOAJ |
| description | The objective of this work is to conduct research on a mathematical model to assess hemolytic characteristics in a channel centrifugal blood pump developed by us with 2000–3400 rpm impeller speed range and 100–250 mmHg pressure drop in different parts of the pump flow path. Hemolysis index was measured at 1 to 10 L/min flow rate. The result was an estimate of the average magnitude of the shear stress (SS), taking into account the distribution in the pump, which ranged from 40 to 60 Pa. The most critical areas of the pump in terms of blood injury were evaluated. The maximum SSs were determined: 456 Pa in the impeller wheel zone and 533.3 Pa in the adjacent area of the body, with an exposure time of 0.0115 s and 0.0821 s respectively. In these zones, maximum hemolysis index values were 0.0420 and 0.0744 respectively. Based on the data obtained, these zones were optimized in terms of minimizing hemolysis. |
| format | Article |
| id | doaj-art-caa2269dbed9483b9fb1eaae53fde5e0 |
| institution | DOAJ |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2020-10-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-caa2269dbed9483b9fb1eaae53fde5e02025-08-20T03:01:38ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912020-10-01223798510.15825/1995-1191-2020-3-79-85898Mathematical evaluation of hemolysis in a channel centrifugal blood pumpA. P. Kuleshov0G. P. Itkin1A. S. Buchnev2A. A. Drobyshev3Shumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial Organs; Moscow Institute of Physics and TechnologyShumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial OrgansThe objective of this work is to conduct research on a mathematical model to assess hemolytic characteristics in a channel centrifugal blood pump developed by us with 2000–3400 rpm impeller speed range and 100–250 mmHg pressure drop in different parts of the pump flow path. Hemolysis index was measured at 1 to 10 L/min flow rate. The result was an estimate of the average magnitude of the shear stress (SS), taking into account the distribution in the pump, which ranged from 40 to 60 Pa. The most critical areas of the pump in terms of blood injury were evaluated. The maximum SSs were determined: 456 Pa in the impeller wheel zone and 533.3 Pa in the adjacent area of the body, with an exposure time of 0.0115 s and 0.0821 s respectively. In these zones, maximum hemolysis index values were 0.0420 and 0.0744 respectively. Based on the data obtained, these zones were optimized in terms of minimizing hemolysis.https://journal.transpl.ru/vtio/article/view/12303d modelingmechanical circulatory supportchannel centrifugal blood pumpshear stressexposure timehemolysis index |
| spellingShingle | A. P. Kuleshov G. P. Itkin A. S. Buchnev A. A. Drobyshev Mathematical evaluation of hemolysis in a channel centrifugal blood pump Вестник трансплантологии и искусственных органов 3d modeling mechanical circulatory support channel centrifugal blood pump shear stress exposure time hemolysis index |
| title | Mathematical evaluation of hemolysis in a channel centrifugal blood pump |
| title_full | Mathematical evaluation of hemolysis in a channel centrifugal blood pump |
| title_fullStr | Mathematical evaluation of hemolysis in a channel centrifugal blood pump |
| title_full_unstemmed | Mathematical evaluation of hemolysis in a channel centrifugal blood pump |
| title_short | Mathematical evaluation of hemolysis in a channel centrifugal blood pump |
| title_sort | mathematical evaluation of hemolysis in a channel centrifugal blood pump |
| topic | 3d modeling mechanical circulatory support channel centrifugal blood pump shear stress exposure time hemolysis index |
| url | https://journal.transpl.ru/vtio/article/view/1230 |
| work_keys_str_mv | AT apkuleshov mathematicalevaluationofhemolysisinachannelcentrifugalbloodpump AT gpitkin mathematicalevaluationofhemolysisinachannelcentrifugalbloodpump AT asbuchnev mathematicalevaluationofhemolysisinachannelcentrifugalbloodpump AT aadrobyshev mathematicalevaluationofhemolysisinachannelcentrifugalbloodpump |