Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy
Abstract Photodynamic therapy (PDT) has emerged as a promising strategy for cancer treatment due to its non‐invasive nature and high specificity toward malignant tissues. In recent years, a variety of protocols have been proposed to improve the PDT efficacy, of which organelle‐targeted PDT strategy...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Aggregate |
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| Online Access: | https://doi.org/10.1002/agt2.665 |
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| author | Shan Wang Qiang Wang Yang Lv Zhe Liu Kippeum Lee Dongeun Kim Miae Won Jianliang Shen Jong Seung Kim |
| author_facet | Shan Wang Qiang Wang Yang Lv Zhe Liu Kippeum Lee Dongeun Kim Miae Won Jianliang Shen Jong Seung Kim |
| author_sort | Shan Wang |
| collection | DOAJ |
| description | Abstract Photodynamic therapy (PDT) has emerged as a promising strategy for cancer treatment due to its non‐invasive nature and high specificity toward malignant tissues. In recent years, a variety of protocols have been proposed to improve the PDT efficacy, of which organelle‐targeted PDT strategy is supposed to be quite promising. Particularly, lipid droplets (LDs)‐localized PDT attracts a lot of interest due to the inherent advantages such as abundant LDs in cancer cells and their close relation with ferroptosis. This review provides a comprehensive summary of the advancements of LDs‐localized photosensitizers (PSs) according to their chemical structures and functions. Especially, these PSs are featured with fluorescence emission, thereby facilitating an imaging‐guided phototherapy. The review highlights the cytocidal actions of these PSs, such as the cell death pathway and their cytotoxicity. Finally, some unresolved issues and challenges in this domain will be discussed. |
| format | Article |
| id | doaj-art-caa0d967f70b48b59b44f4fbf7c3d31b |
| institution | Kabale University |
| issn | 2692-4560 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aggregate |
| spelling | doaj-art-caa0d967f70b48b59b44f4fbf7c3d31b2025-01-21T08:57:07ZengWileyAggregate2692-45602025-01-0161n/an/a10.1002/agt2.665Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapyShan Wang0Qiang Wang1Yang Lv2Zhe Liu3Kippeum Lee4Dongeun Kim5Miae Won6Jianliang Shen7Jong Seung Kim8Zhejiang Key Laboratory of Critical Care Medicine The First Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Ophthalmology Third Affiliated Hospital Wenzhou Medical University Ruian ChinaNational Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University Wenzhou ChinaNational Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University Wenzhou ChinaDepartment of Chemistry Korea University Seoul South KoreaDepartment of Chemistry Korea University Seoul South KoreaDepartment of Chemistry Korea University Seoul South KoreaNational Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University Wenzhou ChinaDepartment of Chemistry Korea University Seoul South KoreaAbstract Photodynamic therapy (PDT) has emerged as a promising strategy for cancer treatment due to its non‐invasive nature and high specificity toward malignant tissues. In recent years, a variety of protocols have been proposed to improve the PDT efficacy, of which organelle‐targeted PDT strategy is supposed to be quite promising. Particularly, lipid droplets (LDs)‐localized PDT attracts a lot of interest due to the inherent advantages such as abundant LDs in cancer cells and their close relation with ferroptosis. This review provides a comprehensive summary of the advancements of LDs‐localized photosensitizers (PSs) according to their chemical structures and functions. Especially, these PSs are featured with fluorescence emission, thereby facilitating an imaging‐guided phototherapy. The review highlights the cytocidal actions of these PSs, such as the cell death pathway and their cytotoxicity. Finally, some unresolved issues and challenges in this domain will be discussed.https://doi.org/10.1002/agt2.665aggregation‐induced emissionintramolecular charge transferlipid dropletphotodynamic therapyphotosensitizers |
| spellingShingle | Shan Wang Qiang Wang Yang Lv Zhe Liu Kippeum Lee Dongeun Kim Miae Won Jianliang Shen Jong Seung Kim Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy Aggregate aggregation‐induced emission intramolecular charge transfer lipid droplet photodynamic therapy photosensitizers |
| title | Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy |
| title_full | Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy |
| title_fullStr | Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy |
| title_full_unstemmed | Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy |
| title_short | Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy |
| title_sort | fluorescence imaging guided lipid droplets localized photodynamic therapy |
| topic | aggregation‐induced emission intramolecular charge transfer lipid droplet photodynamic therapy photosensitizers |
| url | https://doi.org/10.1002/agt2.665 |
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