Association between influenza vaccine effectiveness and chronic diseases among older adults with dementia
Abstract This retrospective cohort study aimed to assess whether influenza vaccination reduces hospitalization rates and morbidity such as pneumonia incidence among older adults aged 80 years and above with severe dementia. Participants were grouped according to their influenza vaccination status. T...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-10633-7 |
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| author | Pavel Mutter Anat Romem |
| author_facet | Pavel Mutter Anat Romem |
| author_sort | Pavel Mutter |
| collection | DOAJ |
| description | Abstract This retrospective cohort study aimed to assess whether influenza vaccination reduces hospitalization rates and morbidity such as pneumonia incidence among older adults aged 80 years and above with severe dementia. Participants were grouped according to their influenza vaccination status. The primary outcomes evaluated included hospitalization rates, pneumonia incidence, and antibiotic use. Logistic regression models were used to predict pneumonia, and hospitalizations by the primary demographic and clinical characteristics. A total of 2,052 individuals were included in this study. Unvaccinated older adult patients had the lowest risk of being diagnosed with pneumonia and hospitalization. Female sex and Unvaccinated status were protective factors (OR = 0.389, 95%CI = 0.206, 0.733). The expected protective effects of the vaccine on pneumonia incidence and hospitalization may be less pronounced among older adults living with dementia. There is a need for more tailored influenza vaccination strategies for older adults with severe dementia and comorbid conditions. |
| format | Article |
| id | doaj-art-caa0161c0cc14e0f9c873d7260b8d483 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-caa0161c0cc14e0f9c873d7260b8d4832025-08-20T03:46:08ZengNature PortfolioScientific Reports2045-23222025-07-011511910.1038/s41598-025-10633-7Association between influenza vaccine effectiveness and chronic diseases among older adults with dementiaPavel Mutter0Anat Romem1Meuhedet Health ServicesJerusalem College of Technology, Herzog Medical CenterAbstract This retrospective cohort study aimed to assess whether influenza vaccination reduces hospitalization rates and morbidity such as pneumonia incidence among older adults aged 80 years and above with severe dementia. Participants were grouped according to their influenza vaccination status. The primary outcomes evaluated included hospitalization rates, pneumonia incidence, and antibiotic use. Logistic regression models were used to predict pneumonia, and hospitalizations by the primary demographic and clinical characteristics. A total of 2,052 individuals were included in this study. Unvaccinated older adult patients had the lowest risk of being diagnosed with pneumonia and hospitalization. Female sex and Unvaccinated status were protective factors (OR = 0.389, 95%CI = 0.206, 0.733). The expected protective effects of the vaccine on pneumonia incidence and hospitalization may be less pronounced among older adults living with dementia. There is a need for more tailored influenza vaccination strategies for older adults with severe dementia and comorbid conditions.https://doi.org/10.1038/s41598-025-10633-7DementiaOlder adultsInfluenzaVaccination |
| spellingShingle | Pavel Mutter Anat Romem Association between influenza vaccine effectiveness and chronic diseases among older adults with dementia Scientific Reports Dementia Older adults Influenza Vaccination |
| title | Association between influenza vaccine effectiveness and chronic diseases among older adults with dementia |
| title_full | Association between influenza vaccine effectiveness and chronic diseases among older adults with dementia |
| title_fullStr | Association between influenza vaccine effectiveness and chronic diseases among older adults with dementia |
| title_full_unstemmed | Association between influenza vaccine effectiveness and chronic diseases among older adults with dementia |
| title_short | Association between influenza vaccine effectiveness and chronic diseases among older adults with dementia |
| title_sort | association between influenza vaccine effectiveness and chronic diseases among older adults with dementia |
| topic | Dementia Older adults Influenza Vaccination |
| url | https://doi.org/10.1038/s41598-025-10633-7 |
| work_keys_str_mv | AT pavelmutter associationbetweeninfluenzavaccineeffectivenessandchronicdiseasesamongolderadultswithdementia AT anatromem associationbetweeninfluenzavaccineeffectivenessandchronicdiseasesamongolderadultswithdementia |