The Association Between the Atherogenic Index of Plasma and Cognitive Function: Evidence From the NHANES 2011–2014
ABSTRACT Background Atherosclerosis is the primary cause of cerebrovascular disease, which in turn has substantial deleterious impacts on cognitive abilities. The atherogenic index of plasma (AIP), calculated as the logarithmic transformation of the ratio of triglycerides to high‐density lipoprotein...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70768 |
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| author | Pingping Huang Gaocan Ren Yifei Wang Yicheng Liu Hongwei Zhang Shuangqing Fu Zhibo Zhang Lijun Guo Xiaochang Ma |
| author_facet | Pingping Huang Gaocan Ren Yifei Wang Yicheng Liu Hongwei Zhang Shuangqing Fu Zhibo Zhang Lijun Guo Xiaochang Ma |
| author_sort | Pingping Huang |
| collection | DOAJ |
| description | ABSTRACT Background Atherosclerosis is the primary cause of cerebrovascular disease, which in turn has substantial deleterious impacts on cognitive abilities. The atherogenic index of plasma (AIP), calculated as the logarithmic transformation of the ratio of triglycerides to high‐density lipoprotein cholesterol (log[TG/HDL‐C]), has emerged as a novel biomarker reflecting the balance between proatherogenic and antiatherogenic lipoproteins. Nevertheless, the association between AIP and cognitive function has not been examined in a large cohort. This study examined the relationship between AIP and cognitive performance in a nationally representative cohort of adult Americans. Methods A cross‐sectional study was conducted using data from the 2011–2014 National Health and Nutrition Examination Survey (NHANES). The relationship between AIP and cognitive function was examined using several multivariate regression models with adjustment for arrays of potential confound factors. Fitted smoothed curves and threshold effect analysis were used to characterize possible nonlinear relationships. Results The study population comprised 995 adults (mean age 63.01 ± 14.93 years; 51.86% female), with 49.65% identifying as non‐Hispanic White, 9.15% as Mexican American, and 20.2% as non‐Hispanic Black. Higher AIP was associated with greater risk of cognitive impairment. Negative correlations were detected between the AIP and both Animal Fluency Test (AFT) performance (β = ‐5.54, 95%CI: ‐9.26, ‐1.82, p < 0.05) and Digit Symbol Substitution Test (DSST) performance (β = ‐15.79, 95% CI: ‐26.32, ‐5.27, p < 0.05) after adjusting for multiple confounding variables. Conclusion Elevated AIP is associated with cognitive impairment in adult Americans. |
| format | Article |
| id | doaj-art-ca9f9e8f965749f896f9e4594388e092 |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-ca9f9e8f965749f896f9e4594388e0922025-08-23T04:41:01ZengWileyBrain and Behavior2162-32792025-08-01158n/an/a10.1002/brb3.70768The Association Between the Atherogenic Index of Plasma and Cognitive Function: Evidence From the NHANES 2011–2014Pingping Huang0Gaocan Ren1Yifei Wang2Yicheng Liu3Hongwei Zhang4Shuangqing Fu5Zhibo Zhang6Lijun Guo7Xiaochang Ma8Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing ChinaXiyuan Hospital China Academy of Chinese Medical Sciences Beijing ChinaGraduate School China Academy of Chinese Medical Sciences Beijing ChinaXiyuan Hospital China Academy of Chinese Medical Sciences Beijing ChinaXiyuan Hospital China Academy of Chinese Medical Sciences Beijing ChinaGraduate School China Academy of Chinese Medical Sciences Beijing ChinaGraduate School China Academy of Chinese Medical Sciences Beijing ChinaNational Clinical Research Center for Chinese Medicine Cardiology Beijing ChinaNational Clinical Research Center for Chinese Medicine Cardiology Beijing ChinaABSTRACT Background Atherosclerosis is the primary cause of cerebrovascular disease, which in turn has substantial deleterious impacts on cognitive abilities. The atherogenic index of plasma (AIP), calculated as the logarithmic transformation of the ratio of triglycerides to high‐density lipoprotein cholesterol (log[TG/HDL‐C]), has emerged as a novel biomarker reflecting the balance between proatherogenic and antiatherogenic lipoproteins. Nevertheless, the association between AIP and cognitive function has not been examined in a large cohort. This study examined the relationship between AIP and cognitive performance in a nationally representative cohort of adult Americans. Methods A cross‐sectional study was conducted using data from the 2011–2014 National Health and Nutrition Examination Survey (NHANES). The relationship between AIP and cognitive function was examined using several multivariate regression models with adjustment for arrays of potential confound factors. Fitted smoothed curves and threshold effect analysis were used to characterize possible nonlinear relationships. Results The study population comprised 995 adults (mean age 63.01 ± 14.93 years; 51.86% female), with 49.65% identifying as non‐Hispanic White, 9.15% as Mexican American, and 20.2% as non‐Hispanic Black. Higher AIP was associated with greater risk of cognitive impairment. Negative correlations were detected between the AIP and both Animal Fluency Test (AFT) performance (β = ‐5.54, 95%CI: ‐9.26, ‐1.82, p < 0.05) and Digit Symbol Substitution Test (DSST) performance (β = ‐15.79, 95% CI: ‐26.32, ‐5.27, p < 0.05) after adjusting for multiple confounding variables. Conclusion Elevated AIP is associated with cognitive impairment in adult Americans.https://doi.org/10.1002/brb3.70768atherogenic index of plasmacognitive functioncross‐sectional studyNHANES |
| spellingShingle | Pingping Huang Gaocan Ren Yifei Wang Yicheng Liu Hongwei Zhang Shuangqing Fu Zhibo Zhang Lijun Guo Xiaochang Ma The Association Between the Atherogenic Index of Plasma and Cognitive Function: Evidence From the NHANES 2011–2014 Brain and Behavior atherogenic index of plasma cognitive function cross‐sectional study NHANES |
| title | The Association Between the Atherogenic Index of Plasma and Cognitive Function: Evidence From the NHANES 2011–2014 |
| title_full | The Association Between the Atherogenic Index of Plasma and Cognitive Function: Evidence From the NHANES 2011–2014 |
| title_fullStr | The Association Between the Atherogenic Index of Plasma and Cognitive Function: Evidence From the NHANES 2011–2014 |
| title_full_unstemmed | The Association Between the Atherogenic Index of Plasma and Cognitive Function: Evidence From the NHANES 2011–2014 |
| title_short | The Association Between the Atherogenic Index of Plasma and Cognitive Function: Evidence From the NHANES 2011–2014 |
| title_sort | association between the atherogenic index of plasma and cognitive function evidence from the nhanes 2011 2014 |
| topic | atherogenic index of plasma cognitive function cross‐sectional study NHANES |
| url | https://doi.org/10.1002/brb3.70768 |
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