Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy
The wt-1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context. The wt-1 regulates the expression of a large number of genes that have a critical role in kidney development. Congenital obstructive nephrop...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2013/401750 |
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| author | Luciana Mazzei Walter Manucha |
| author_facet | Luciana Mazzei Walter Manucha |
| author_sort | Luciana Mazzei |
| collection | DOAJ |
| description | The wt-1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context. The wt-1 regulates the expression of a large number of genes that have a critical role in kidney development. Congenital obstructive nephropathy disrupts normal renal development and causes chronic progressive interstitial fibrosis, which contributes to renal growth arrest, ultimately leading to chronic renal failure. Wt-1 is downregulated during congenital obstructive nephropathy, leading to apoptosis. Of great interest, nitric oxide bioavailability associated with heat shock protein 70 (Hsp70) interaction may modulate wt-1 mRNA expression, preventing obstruction-induced cell death during neonatal unilateral ureteral obstruction. Moreover, recent genetic researches have allowed characterization of many of the complex interactions among the individual components cited, but the realization of new biochemical, molecular, and functional experiments as proposed in our and other research labs allows us to establish a deeper level of commitment among proteins involved and the potential pathogenic consequences of their imbalance. |
| format | Article |
| id | doaj-art-ca9c8c47333c4c3b8fb3a8d21d2e22c1 |
| institution | OA Journals |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-ca9c8c47333c4c3b8fb3a8d21d2e22c12025-08-20T02:19:34ZengWileyAdvances in Urology1687-63691687-63772013-01-01201310.1155/2013/401750401750Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive NephropathyLuciana Mazzei0Walter Manucha1Área de Fisiopatología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Centro Universitario, CP 5500, Mendoza, ArgentinaÁrea de Fisiopatología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Centro Universitario, CP 5500, Mendoza, ArgentinaThe wt-1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context. The wt-1 regulates the expression of a large number of genes that have a critical role in kidney development. Congenital obstructive nephropathy disrupts normal renal development and causes chronic progressive interstitial fibrosis, which contributes to renal growth arrest, ultimately leading to chronic renal failure. Wt-1 is downregulated during congenital obstructive nephropathy, leading to apoptosis. Of great interest, nitric oxide bioavailability associated with heat shock protein 70 (Hsp70) interaction may modulate wt-1 mRNA expression, preventing obstruction-induced cell death during neonatal unilateral ureteral obstruction. Moreover, recent genetic researches have allowed characterization of many of the complex interactions among the individual components cited, but the realization of new biochemical, molecular, and functional experiments as proposed in our and other research labs allows us to establish a deeper level of commitment among proteins involved and the potential pathogenic consequences of their imbalance.http://dx.doi.org/10.1155/2013/401750 |
| spellingShingle | Luciana Mazzei Walter Manucha Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy Advances in Urology |
| title | Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy |
| title_full | Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy |
| title_fullStr | Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy |
| title_full_unstemmed | Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy |
| title_short | Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy |
| title_sort | wt 1 expression linked to nitric oxide availability during neonatal obstructive nephropathy |
| url | http://dx.doi.org/10.1155/2013/401750 |
| work_keys_str_mv | AT lucianamazzei wt1expressionlinkedtonitricoxideavailabilityduringneonatalobstructivenephropathy AT waltermanucha wt1expressionlinkedtonitricoxideavailabilityduringneonatalobstructivenephropathy |