Eliminating lead-exposure in nebulization therapy by lead-free piezoelectric
Abstract Present main-stream medical ultrasonic nebulizers contain Pb(Zr,Ti)O3-based piezoceramics, which could expose the patients to toxic lead when the acidic liquid medicine, compounded with ultrasonic vibration, corrodes the piezoceramics. Enormous amount of lead ions up to 150 ppm can be extra...
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| Format: | Article |
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Nature Portfolio
2025-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61993-7 |
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| author | Fang-Zhou Yao Wenying Fan Yunfan Zhang Bing Han Zimin Feng Binjie Chen Zhongshang Dou Jia Jiang Ziyun Li Haihan Gao Chaofeng Wu Naixin Liang Yan Wei Ke Wang Xin Ma Wen Gong |
| author_facet | Fang-Zhou Yao Wenying Fan Yunfan Zhang Bing Han Zimin Feng Binjie Chen Zhongshang Dou Jia Jiang Ziyun Li Haihan Gao Chaofeng Wu Naixin Liang Yan Wei Ke Wang Xin Ma Wen Gong |
| author_sort | Fang-Zhou Yao |
| collection | DOAJ |
| description | Abstract Present main-stream medical ultrasonic nebulizers contain Pb(Zr,Ti)O3-based piezoceramics, which could expose the patients to toxic lead when the acidic liquid medicine, compounded with ultrasonic vibration, corrodes the piezoceramics. Enormous amount of lead ions up to 150 ppm can be extracted when lead-containing piezoceramics were exposed to typical acidic liquid medicines. Thus, a series of nebulization in a course of treatment could easily raise a child’s blood lead level well above the blood lead reference value of 0.035 ppm, causing adverse and likely irreversible health effects. Herein, we introduce the lead-free medical ultrasonic nebulizers based on high-performance (K,Na)NbO3-based lead-free piezoceramics. It’s designed for facile and safe at-home treatment, offering a healthy, safe, and lead-free solution for patients. It also marks the first commercialization of (K,Na)NbO3-based lead-free piezoceramics as a replacement for Pb(Zr,Ti)O3, helping expedite the lead-removing process of piezoelectric materials in general, in line with sustainable development goals worldwide. |
| format | Article |
| id | doaj-art-ca994650e34f46ecabc073ef17da5d52 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-ca994650e34f46ecabc073ef17da5d522025-08-20T03:46:25ZengNature PortfolioNature Communications2041-17232025-08-011611810.1038/s41467-025-61993-7Eliminating lead-exposure in nebulization therapy by lead-free piezoelectricFang-Zhou Yao0Wenying Fan1Yunfan Zhang2Bing Han3Zimin Feng4Binjie Chen5Zhongshang Dou6Jia Jiang7Ziyun Li8Haihan Gao9Chaofeng Wu10Naixin Liang11Yan Wei12Ke Wang13Xin Ma14Wen Gong15Research Center for Advanced Functional Ceramics, Wuzhen LaboratoryResearch Center for Advanced Functional Ceramics, Wuzhen LaboratoryDepartment of Geriatric Dentistry, NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of StomatologyDepartment of Orthodontics, Peking University School and Hospital of StomatologyResearch Center for Advanced Functional Ceramics, Wuzhen LaboratoryResearch Center for Advanced Functional Ceramics, Wuzhen LaboratoryResearch Center for Advanced Functional Ceramics, Wuzhen LaboratoryShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineTongxiang Tsingfeng Technology Co. LtdDepartment of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Geriatric Dentistry, NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of StomatologyResearch Center for Advanced Functional Ceramics, Wuzhen LaboratoryShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineResearch Center for Advanced Functional Ceramics, Wuzhen LaboratoryAbstract Present main-stream medical ultrasonic nebulizers contain Pb(Zr,Ti)O3-based piezoceramics, which could expose the patients to toxic lead when the acidic liquid medicine, compounded with ultrasonic vibration, corrodes the piezoceramics. Enormous amount of lead ions up to 150 ppm can be extracted when lead-containing piezoceramics were exposed to typical acidic liquid medicines. Thus, a series of nebulization in a course of treatment could easily raise a child’s blood lead level well above the blood lead reference value of 0.035 ppm, causing adverse and likely irreversible health effects. Herein, we introduce the lead-free medical ultrasonic nebulizers based on high-performance (K,Na)NbO3-based lead-free piezoceramics. It’s designed for facile and safe at-home treatment, offering a healthy, safe, and lead-free solution for patients. It also marks the first commercialization of (K,Na)NbO3-based lead-free piezoceramics as a replacement for Pb(Zr,Ti)O3, helping expedite the lead-removing process of piezoelectric materials in general, in line with sustainable development goals worldwide.https://doi.org/10.1038/s41467-025-61993-7 |
| spellingShingle | Fang-Zhou Yao Wenying Fan Yunfan Zhang Bing Han Zimin Feng Binjie Chen Zhongshang Dou Jia Jiang Ziyun Li Haihan Gao Chaofeng Wu Naixin Liang Yan Wei Ke Wang Xin Ma Wen Gong Eliminating lead-exposure in nebulization therapy by lead-free piezoelectric Nature Communications |
| title | Eliminating lead-exposure in nebulization therapy by lead-free piezoelectric |
| title_full | Eliminating lead-exposure in nebulization therapy by lead-free piezoelectric |
| title_fullStr | Eliminating lead-exposure in nebulization therapy by lead-free piezoelectric |
| title_full_unstemmed | Eliminating lead-exposure in nebulization therapy by lead-free piezoelectric |
| title_short | Eliminating lead-exposure in nebulization therapy by lead-free piezoelectric |
| title_sort | eliminating lead exposure in nebulization therapy by lead free piezoelectric |
| url | https://doi.org/10.1038/s41467-025-61993-7 |
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