Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in China
Introduction: Previous studies have indicated that the patients with psychiatric illness were at higher risk of hepatitis B virus (HBV) infection. However, the efficacy of hepatitis B vaccine in schizophrenia patients remains unclear. Methodology: Between June 2014 and January 2015, 415 schizophren...
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The Journal of Infection in Developing Countries
2016-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/7377 |
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| author | Yiying Wang Lugang Yu Hui Zhou Zhiwei Zhou Huijuan Zhu Yinghui Li Zhi Zheng Xinxin Li Chen Dong |
| author_facet | Yiying Wang Lugang Yu Hui Zhou Zhiwei Zhou Huijuan Zhu Yinghui Li Zhi Zheng Xinxin Li Chen Dong |
| author_sort | Yiying Wang |
| collection | DOAJ |
| description | Introduction: Previous studies have indicated that the patients with psychiatric illness were at higher risk of hepatitis B virus (HBV) infection. However, the efficacy of hepatitis B vaccine in schizophrenia patients remains unclear.
Methodology: Between June 2014 and January 2015, 415 schizophrenia patients and 3,038 controls who had been routinely immunized as infants were recruited in the present study. Hepatitis B surface antigen (HBsAg), HBsAb, and HBV DNA were detected with commercial methods according to the manufacturer’s protocol. A 600-bp region of the S gene (region nt236–nt835) was amplified by nested polymerase chain reaction (PCR). The genotypes of isolated HBV were identified using phylogenetic analysis by the neighbor-joining algorithm in the software MEGA version 4.1.
Results: The seroprevalence of HBsAg in schizophrenia patients was 6.75%, which was significantly higher than 3.32% measured in controls. HBsAg prevalence was 7.94% in male schizophrenia patients and 5.47% in female schizophrenia patients, while it was only 4.04% in males and 2.08% in females in the control group. The HBsAb seroprevalence rate was 58.31% in schizophrenia patients and 59.94% in non-schizophrenia controls. Moreover, one HBV strain in the schizophrenia group presented I126S vaccine escape mutation (5.88%), while three HBV isolates showed Q129H, M133L, and G145R vaccine escape mutations in the control group (6.81%).
Conclusions: Schizophrenia patients are at higher risk for HBV infection, even those who had received routine immunization. Therefore, a booster HB vaccination targeted at schizophrenia patients should be considered in the future.
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| format | Article |
| id | doaj-art-ca94bea597d54c2bb99b6bbc5bb0f91f |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2016-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-ca94bea597d54c2bb99b6bbc5bb0f91f2025-08-20T02:14:20ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802016-04-01100410.3855/jidc.7377Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in ChinaYiying Wang0Lugang Yu1Hui Zhou2Zhiwei Zhou3Huijuan Zhu4Yinghui Li5Zhi Zheng6Xinxin Li7Chen Dong8School of Public Health, Medical College of Soochow University, Suzhou, ChinaSuzhou Industrial Park Centers for Disease Control and Prevention, Suzhou, ChinaSuzhou Industrial Park Centers for Disease Control and Prevention, Suzhou, ChinaSchool of Public Health, Medical College of Soochow University, Suzhou, ChinaSchool of Public Health, Medical College of Soochow University, Suzhou, ChinaHuai’an Third Hospital, Huai’an, ChinaHuai’an Third Hospital, Huai’an, ChinaZhangjiagang Women and Children Health Center, Suzhou, ChinaSchool of Public Health, Medical College of Soochow University, Suzhou, ChinaIntroduction: Previous studies have indicated that the patients with psychiatric illness were at higher risk of hepatitis B virus (HBV) infection. However, the efficacy of hepatitis B vaccine in schizophrenia patients remains unclear. Methodology: Between June 2014 and January 2015, 415 schizophrenia patients and 3,038 controls who had been routinely immunized as infants were recruited in the present study. Hepatitis B surface antigen (HBsAg), HBsAb, and HBV DNA were detected with commercial methods according to the manufacturer’s protocol. A 600-bp region of the S gene (region nt236–nt835) was amplified by nested polymerase chain reaction (PCR). The genotypes of isolated HBV were identified using phylogenetic analysis by the neighbor-joining algorithm in the software MEGA version 4.1. Results: The seroprevalence of HBsAg in schizophrenia patients was 6.75%, which was significantly higher than 3.32% measured in controls. HBsAg prevalence was 7.94% in male schizophrenia patients and 5.47% in female schizophrenia patients, while it was only 4.04% in males and 2.08% in females in the control group. The HBsAb seroprevalence rate was 58.31% in schizophrenia patients and 59.94% in non-schizophrenia controls. Moreover, one HBV strain in the schizophrenia group presented I126S vaccine escape mutation (5.88%), while three HBV isolates showed Q129H, M133L, and G145R vaccine escape mutations in the control group (6.81%). Conclusions: Schizophrenia patients are at higher risk for HBV infection, even those who had received routine immunization. Therefore, a booster HB vaccination targeted at schizophrenia patients should be considered in the future. https://jidc.org/index.php/journal/article/view/7377hepatitis B virushepatitis B vaccineschizophreniaseroprevalence |
| spellingShingle | Yiying Wang Lugang Yu Hui Zhou Zhiwei Zhou Huijuan Zhu Yinghui Li Zhi Zheng Xinxin Li Chen Dong Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in China Journal of Infection in Developing Countries hepatitis B virus hepatitis B vaccine schizophrenia seroprevalence |
| title | Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in China |
| title_full | Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in China |
| title_fullStr | Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in China |
| title_full_unstemmed | Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in China |
| title_short | Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in China |
| title_sort | serologic and molecular characteristics of hepatitis b virus infection in vaccinated schizophrenia patients in china |
| topic | hepatitis B virus hepatitis B vaccine schizophrenia seroprevalence |
| url | https://jidc.org/index.php/journal/article/view/7377 |
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