Analysis of Cancer Stem Cell Markers in Various Histological Subtypes of Adrenocortical Cancer
Adrenocortical cancer (ACC) is a rare malignant neoplasm originating from the adrenal cortex, presenting limited therapeutic options. An avenue for improving therapeutic efficacy may involve a deeper understanding of the role of adrenocortical stem/progenitor cells in the pathogenesis of this diseas...
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MDPI AG
2024-12-01
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| Series: | Current Issues in Molecular Biology |
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| author | Nano Pachuashvili Asya Bastrich Erika Porubayeva Alina Elfimova Alexander Tertychnyy Dmitry Beltsevich Evgeniya Kogan Igor Reshetov Ekaterina Troshina Natalia Tarbaeva Natalia Mokrysheva Liliya Urusova |
| author_facet | Nano Pachuashvili Asya Bastrich Erika Porubayeva Alina Elfimova Alexander Tertychnyy Dmitry Beltsevich Evgeniya Kogan Igor Reshetov Ekaterina Troshina Natalia Tarbaeva Natalia Mokrysheva Liliya Urusova |
| author_sort | Nano Pachuashvili |
| collection | DOAJ |
| description | Adrenocortical cancer (ACC) is a rare malignant neoplasm originating from the adrenal cortex, presenting limited therapeutic options. An avenue for improving therapeutic efficacy may involve a deeper understanding of the role of adrenocortical stem/progenitor cells in the pathogenesis of this disease. Although existing data suggest stem/progenitor characteristics in certain cell populations within ACC, the challenge remains to identify adrenocortical stem cell markers directly involved in its carcinogenesis. In our study, we aimed to identify multipotency markers such as LGR5 and CD90 in various ACC types to confirm their presence and localization. The study included tumor tissue samples from 13 patients with ACC treated at the Endocrinology Research Centre (Moscow, Russia) between 2005 and 2023. We conducted immunohistochemical analyses to identify the aforementioned markers and examined the association between their expression and clinico-morphological parameters. Our pilot study results demonstrate the presence of LGR5- and CD90-positive tumor cells in all samples. Despite the small sample size, we observed statistically significant differences in disease-free survival based on the number of CD90-positive cells. These findings suggest a potential diagnostic, prognostic, and predictive value of cancer stem cell markers, underscoring the need for their further analysis in a larger cohort of patients with ACC. |
| format | Article |
| id | doaj-art-ca9439f85d414feeadf290fe430ef3ed |
| institution | DOAJ |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-ca9439f85d414feeadf290fe430ef3ed2025-08-20T02:55:52ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-12-014612137981381010.3390/cimb46120825Analysis of Cancer Stem Cell Markers in Various Histological Subtypes of Adrenocortical CancerNano Pachuashvili0Asya Bastrich1Erika Porubayeva2Alina Elfimova3Alexander Tertychnyy4Dmitry Beltsevich5Evgeniya Kogan6Igor Reshetov7Ekaterina Troshina8Natalia Tarbaeva9Natalia Mokrysheva10Liliya Urusova11Department of Fundamental Pathology, Endocrinology Research Centre, 117036 Moscow, RussiaDepartment of Fundamental Pathology, Endocrinology Research Centre, 117036 Moscow, RussiaFaculty of Fundamental Medicine, Lomonosov Moscow State University, 117192 Moscow, RussiaDepartment of Fundamental Pathology, Endocrinology Research Centre, 117036 Moscow, RussiaInstitute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, RussiaDepartment of Fundamental Pathology, Endocrinology Research Centre, 117036 Moscow, RussiaInstitute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, RussiaInstitute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, RussiaDepartment of Fundamental Pathology, Endocrinology Research Centre, 117036 Moscow, RussiaDepartment of Fundamental Pathology, Endocrinology Research Centre, 117036 Moscow, RussiaDepartment of Fundamental Pathology, Endocrinology Research Centre, 117036 Moscow, RussiaDepartment of Fundamental Pathology, Endocrinology Research Centre, 117036 Moscow, RussiaAdrenocortical cancer (ACC) is a rare malignant neoplasm originating from the adrenal cortex, presenting limited therapeutic options. An avenue for improving therapeutic efficacy may involve a deeper understanding of the role of adrenocortical stem/progenitor cells in the pathogenesis of this disease. Although existing data suggest stem/progenitor characteristics in certain cell populations within ACC, the challenge remains to identify adrenocortical stem cell markers directly involved in its carcinogenesis. In our study, we aimed to identify multipotency markers such as LGR5 and CD90 in various ACC types to confirm their presence and localization. The study included tumor tissue samples from 13 patients with ACC treated at the Endocrinology Research Centre (Moscow, Russia) between 2005 and 2023. We conducted immunohistochemical analyses to identify the aforementioned markers and examined the association between their expression and clinico-morphological parameters. Our pilot study results demonstrate the presence of LGR5- and CD90-positive tumor cells in all samples. Despite the small sample size, we observed statistically significant differences in disease-free survival based on the number of CD90-positive cells. These findings suggest a potential diagnostic, prognostic, and predictive value of cancer stem cell markers, underscoring the need for their further analysis in a larger cohort of patients with ACC.https://www.mdpi.com/1467-3045/46/12/825cancer stem cellsadrenocortical cancermarkers of cancer stem cellsmarkers of multipotent stem cells |
| spellingShingle | Nano Pachuashvili Asya Bastrich Erika Porubayeva Alina Elfimova Alexander Tertychnyy Dmitry Beltsevich Evgeniya Kogan Igor Reshetov Ekaterina Troshina Natalia Tarbaeva Natalia Mokrysheva Liliya Urusova Analysis of Cancer Stem Cell Markers in Various Histological Subtypes of Adrenocortical Cancer Current Issues in Molecular Biology cancer stem cells adrenocortical cancer markers of cancer stem cells markers of multipotent stem cells |
| title | Analysis of Cancer Stem Cell Markers in Various Histological Subtypes of Adrenocortical Cancer |
| title_full | Analysis of Cancer Stem Cell Markers in Various Histological Subtypes of Adrenocortical Cancer |
| title_fullStr | Analysis of Cancer Stem Cell Markers in Various Histological Subtypes of Adrenocortical Cancer |
| title_full_unstemmed | Analysis of Cancer Stem Cell Markers in Various Histological Subtypes of Adrenocortical Cancer |
| title_short | Analysis of Cancer Stem Cell Markers in Various Histological Subtypes of Adrenocortical Cancer |
| title_sort | analysis of cancer stem cell markers in various histological subtypes of adrenocortical cancer |
| topic | cancer stem cells adrenocortical cancer markers of cancer stem cells markers of multipotent stem cells |
| url | https://www.mdpi.com/1467-3045/46/12/825 |
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