Multiple roles for a mitochondrial enzyme

Multiple roles for a mitochondrial enzyme

The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.

Saved in:

Bibliographic Details
Main Authors:	Xicong Tang, Hongyu Qiu
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-06-01
Series:	eLife
Subjects:	aging arginase heart inflammation fibrosis macrophages
Online Access:	https://elifesciences.org/articles/107882
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Effect of ARG1 Gene (rs2781666) Polymorphism on Plasma Arginase Activity and Bronchial Asthma Prevalence and Severity
by: Al-Ghunmieen EM, et al.
Published: (2025-06-01)

Toxoplasma calcium-dependent protein kinases 3 mediates M1 macrophage polarization by targeting host Arginase-1
by: Ran An, et al.
Published: (2025-05-01)

Galectin-3/Gelatin Electrospun Scaffolds Modulate Collagen Synthesis in Skin Healing but Do Not Improve Wound Closure Kinetics
by: Karrington A. McLeod, et al.
Published: (2024-09-01)

Naked mole-rat macrophage polarization
by: E. A. Gorshkova, et al.
Published: (2024-07-01)

Therapeutic potential of natural arginase modulators: mechanisms, challenges, and future directions
by: Ting Li, et al.
Published: (2025-04-01)

Prosopis africana extract inhibits critical enzymes associated with hypertension in vitro and in cyclosporine-induced hypertensive rats
by: Okukwe Christa Obode, et al.
Published: (2024-12-01)

The crucial role of metabolic reprogramming in driving macrophage conversion in kidney disease
by: Na Gong, et al.
Published: (2025-06-01)

Na+,-K+-ATPase Deficiency Exacerbates Cardiac Fibrosis via Promoting ERRα-Mediated Myocardial Cell Injury and Macrophage Activation Under Isoproterenol-Challenged Conditions
by: Ting Lei, et al.
Published: (2025-07-01)

Lung disease in relation to unique monocyte-macrophage subpopulations induced by combined inhalant endotoxin and collagen-induced arthritis
by: Jill A. Poole, et al.
Published: (2025-04-01)

Aerosol inhalation of dimeric artesunate phospholipid-conjugated liposomes ameliorates inflammation, fibrosis, and ferroptosis in neonatal mice with hyperoxia-induced lung injury
by: Rong Guan, et al.
Published: (2025-07-01)

The effect of the use of vacuum therapy and instillation of L-arginine in the treatment of purulent wounds on the activity of nitric oxide cycle enzymes
by: T.V. Horodova-Andrieieva, et al.
Published: (2025-03-01)

Exogenous Ubiquitin Differentially Modulates the Phenotype and Function of M1 and M2 Macrophages
by: Paige L. Shook, et al.
Published: (2025-06-01)

The Role of Cardiac Macrophages in Inflammation and Fibrosis after Myocardial Ischemia-Reperfusion
by: Kaiqin Jin, et al.
Published: (2024-11-01)

A network pharmacology approach confirms Biejiaxiaozheng pills combat hepatic fibrosis by modulating macrophage inflammation and hepatic stellate cell activation
by: Weibin Wu, et al.
Published: (2025-07-01)

Chitosan treatment abrogates hypercholesterolemia-induced erythrocyte’s arginase activation
by: Gamaleldin I. Harisa, et al.
Published: (2017-01-01)

Platelet life cycle during aging: function, production and clearance
by: Friedrich Reusswig, et al.
Published: (2024-12-01)

Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models
by: Katarzyna Drzewicka, et al.
Published: (2025-05-01)

Correction: Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models
by: Frontiers Production Office
Published: (2025-08-01)

Extracellular PKM2 modulates cancer immunity by regulating macrophage polarity
by: Guangda Peng, et al.
Published: (2025-05-01)

Changes of plasma arginase I levels in hemodialysis patients with coronary heart disease
by: WEN Hong-mei, et al.
Published: (2015-01-01)

Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of <i>Leishmania amazonensis</i> Promastigotes and Intracellular Amastigotes
by: Edson Roberto da Silva, et al.
Published: (2025-04-01)

Homoarginine, the methylene homologue of arginine, as a substrate of human arginine:glycine amidinotransferase and arginases
by: E. S. Alekseevskaya, et al.
Published: (2018-03-01)

Disturbance of Arginase Activity and Nitric Oxide Levels in Iraqi Type 2 Diabetes Mellitus
by: Baghdad Science Journal
Published: (2018-06-01)

Exploring the Potential of Malvidin and Echiodinin as Probable Antileishmanial Agents Through In Silico Analysis and In Vitro Efficacy
by: Luis Daniel Goyzueta-Mamani, et al.
Published: (2025-01-01)

Pathophysiology of Angiotensin II-Mediated Hypertension, Cardiac Hypertrophy, and Failure: A Perspective from Macrophages
by: Kelly Carter, et al.
Published: (2024-12-01)

Molecular Mechanisms Underlying Heart Failure and Their Therapeutic Potential
by: Oveena Fonseka, et al.
Published: (2025-02-01)

Adalimumab Treatment Effects on Inflammation and Adipose Tissue Mitochondrial Respiration in Hidradenitis Suppurativa
by: Ronni Eg Sahl, et al.
Published: (2024-11-01)

Purification of a chemotherapeutic agent, L-Arginase, from Pseudomonas aeruginosa isolated from soil
by: Zainab Abbas Abd, et al.
Published: (2024-06-01)

Macrophages and fibroblasts in cardiac fibrosis: interactions and transformation
by: Daehun Kim, et al.
Published: (2025-08-01)

Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32‐Dependent Manner
by: Bon‐Hyeock Koo, et al.
Published: (2018-09-01)

Evolving role of myocardial fibrosis in heart failure with preserved ejection fraction
by: Muhammad K. Malik, et al.
Published: (2025-04-01)

Design, Synthesis, and Biological Evaluation of <i>N</i>-Acylhydrazones and Their Activity Against <i>Leishmania amazonensis</i> Promastigotes
by: Caio Eduardo Oliveira Monteiro, et al.
Published: (2025-07-01)

Arginine depletion potentiates standard-of-care chemo-immunotherapy in preclinical models of high-risk neuroblastoma
by: Kimberley M. Hanssen, et al.
Published: (2025-08-01)

Pro-Fibrotic Macrophage Subtypes: SPP1+ Macrophages as a Key Player and Therapeutic Target in Cardiac Fibrosis?
by: Moritz Uhlig, et al.
Published: (2025-02-01)

Ovarian remodeling and aging-related chronic inflammation and fibrosis in the mammalian ovary
by: Yuanyuan Zhu, et al.
Published: (2025-06-01)

HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages
by: Parker S. Woods, et al.
Published: (2025-04-01)

Bioinformatics analysis to investigate the potential relationship between mitochondrial structure and function-related genes and the immune microenvironment in atherosclerosis
by: Hanning Yang, et al.
Published: (2025-05-01)

Saroglitazar Ameliorates Pulmonary Fibrosis Progression in Mice by Suppressing NF-κB Activation and Attenuating Macrophage M1 Polarization
by: Yawen Zhang, et al.
Published: (2025-06-01)

Macrophage migration inhibitory factor mediates joint capsule fibrosis via facilitating phospholipid metabolite PGE2 production in fibroblasts
by: Yuxin Zhang, et al.
Published: (2025-07-01)

Activity of the arginase-NO synthase system and changes in the NO system in peripheral blood serum of pregnant women with fetal growth restriction
by: M.P. Lysyy
Published: (2025-05-01)