Association between matrix metalloproteinases-2 and -9 gene polymorphism with basement membrane disruption in oral lichen planus: A case-control pilot study
Objectives: This study investigated genetic polymorphism of matrix metalloproteinases (MMP) −2 and −9 in oral lichen planus (OLP) and their association with the basement membrane status. Study design: This case-control study involved genotyping of peripheral blood sample of 32 OLP patients and 106 e...
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Elsevier
2022-03-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426822000124 |
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| author | Anubhuti Sood Latha Mary Cherian R. Heera Sanish Sathyan Moinak Banerjee |
| author_facet | Anubhuti Sood Latha Mary Cherian R. Heera Sanish Sathyan Moinak Banerjee |
| author_sort | Anubhuti Sood |
| collection | DOAJ |
| description | Objectives: This study investigated genetic polymorphism of matrix metalloproteinases (MMP) −2 and −9 in oral lichen planus (OLP) and their association with the basement membrane status. Study design: This case-control study involved genotyping of peripheral blood sample of 32 OLP patients and 106 ethnically matched controls. Single nucleotide polymorphisms (SNP) that were assessed in the groups were- MMP9 rs3918242, MMP9 rs17576 and MMP2 rs865094. Basement membrane status of the OLP biopsy samples was microscopically assessed and recorded following Periodic acid Schiff staining. Results: MMP9 rs3918242 showed significant genotypic and allelic associations between OLP subjects and controls. It was also significantly associated with intact basement membranes in OLP cases with increased frequency of ‘TT’ genotype and ‘T’ allele. No association was found with regard to MMP9 rs17576 and MMP2 rs865094. Conclusion: Biallelic substitution at the promoter region of MMP9 (rs3918242) gene may be associated with increased risk of development of OLP. It may be involved in compromising the integrity of the basement membrane junction. |
| format | Article |
| id | doaj-art-ca90d0a0ebad4eacb2347496e72a6530 |
| institution | DOAJ |
| issn | 2212-4268 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-ca90d0a0ebad4eacb2347496e72a65302025-08-20T02:50:29ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682022-03-0112225826210.1016/j.jobcr.2022.03.007Association between matrix metalloproteinases-2 and -9 gene polymorphism with basement membrane disruption in oral lichen planus: A case-control pilot studyAnubhuti Sood0Latha Mary Cherian1R. Heera2Sanish Sathyan3Moinak Banerjee4Department of Oral Pathology and Microbiology, Government Dental College, Kottayam, Kerala, 686001, India; Corresponding author. Present address: Clinical Research Officer, Clinical Development Services Agency, Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana, 121001, India.Department of Oral Pathology and Microbiology, Government Dental College, Kottayam, Kerala, 686001, IndiaDepartment of Oral Pathology and Microbiology, Government Dental College, Kottayam, Kerala, 686001, IndiaHuman Molecular Genetics Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, IndiaHuman Molecular Genetics Laboratory, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, IndiaObjectives: This study investigated genetic polymorphism of matrix metalloproteinases (MMP) −2 and −9 in oral lichen planus (OLP) and their association with the basement membrane status. Study design: This case-control study involved genotyping of peripheral blood sample of 32 OLP patients and 106 ethnically matched controls. Single nucleotide polymorphisms (SNP) that were assessed in the groups were- MMP9 rs3918242, MMP9 rs17576 and MMP2 rs865094. Basement membrane status of the OLP biopsy samples was microscopically assessed and recorded following Periodic acid Schiff staining. Results: MMP9 rs3918242 showed significant genotypic and allelic associations between OLP subjects and controls. It was also significantly associated with intact basement membranes in OLP cases with increased frequency of ‘TT’ genotype and ‘T’ allele. No association was found with regard to MMP9 rs17576 and MMP2 rs865094. Conclusion: Biallelic substitution at the promoter region of MMP9 (rs3918242) gene may be associated with increased risk of development of OLP. It may be involved in compromising the integrity of the basement membrane junction.http://www.sciencedirect.com/science/article/pii/S2212426822000124Oral lichen planusMatrix metalloproteinasesSingle nucleotide polymorphismCase-control study |
| spellingShingle | Anubhuti Sood Latha Mary Cherian R. Heera Sanish Sathyan Moinak Banerjee Association between matrix metalloproteinases-2 and -9 gene polymorphism with basement membrane disruption in oral lichen planus: A case-control pilot study Journal of Oral Biology and Craniofacial Research Oral lichen planus Matrix metalloproteinases Single nucleotide polymorphism Case-control study |
| title | Association between matrix metalloproteinases-2 and -9 gene polymorphism with basement membrane disruption in oral lichen planus: A case-control pilot study |
| title_full | Association between matrix metalloproteinases-2 and -9 gene polymorphism with basement membrane disruption in oral lichen planus: A case-control pilot study |
| title_fullStr | Association between matrix metalloproteinases-2 and -9 gene polymorphism with basement membrane disruption in oral lichen planus: A case-control pilot study |
| title_full_unstemmed | Association between matrix metalloproteinases-2 and -9 gene polymorphism with basement membrane disruption in oral lichen planus: A case-control pilot study |
| title_short | Association between matrix metalloproteinases-2 and -9 gene polymorphism with basement membrane disruption in oral lichen planus: A case-control pilot study |
| title_sort | association between matrix metalloproteinases 2 and 9 gene polymorphism with basement membrane disruption in oral lichen planus a case control pilot study |
| topic | Oral lichen planus Matrix metalloproteinases Single nucleotide polymorphism Case-control study |
| url | http://www.sciencedirect.com/science/article/pii/S2212426822000124 |
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