Association between High-Sensitivity C-Reactive Protein and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Hepatitis C Virus Infection
Background. Prior study showed HCV-infected patients have increased serum N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and a possible left ventricular diastolic dysfunction. The objectives of the present paper were to investigate the characteristics of hs-CRP and its correlation with clinic...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/730923 |
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| author | Wenliang Che Buchun Zhang Wenling Liu Yidong Wei Yawei Xu Dayi Hu |
| author_facet | Wenliang Che Buchun Zhang Wenling Liu Yidong Wei Yawei Xu Dayi Hu |
| author_sort | Wenliang Che |
| collection | DOAJ |
| description | Background. Prior study showed HCV-infected patients have increased serum N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and a possible left ventricular diastolic dysfunction. The objectives of the present paper were to investigate the characteristics of hs-CRP and its correlation with clinical profiles including NT-proBNP and echocardiographic variables in HCV-infected patients. Methods and Results. A total of 106 HCV-infected patients and 106 control healthy individuals were enrolled. The level of serum hs-CRP (median 1.023 mg/L, range 0.03∼5.379 mg/L) was significantly lower in all 106 patients than that in controls (median 3.147 mg/L, range 0.08~7.36 mg/L, P=0.012). Although hs-CRP did not correlate significantly with NT-proBNP when all patients and controls were included (r=0.169, P=0.121), simple regression analysis demonstrated a statistically significant linear correlation between hs-CRP and NT-proBNP in HCV-infected patients group (r=0.392, P=0.017). Independent correlates of hs-CRP levels (R2=0.13) were older age (β′=0.031, P=0.025) and NT proBNP (β′=0.024, P=0.017). Conclusions. Although the level of serum hs-CRP decreased significantly, there was a significant association between hs-CRP and NT-proBNP in HCV-infected patients. |
| format | Article |
| id | doaj-art-ca8f2f73a96f4d8a999b35aaeae44d08 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ca8f2f73a96f4d8a999b35aaeae44d082025-02-03T06:14:15ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/730923730923Association between High-Sensitivity C-Reactive Protein and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Hepatitis C Virus InfectionWenliang Che0Buchun Zhang1Wenling Liu2Yidong Wei3Yawei Xu4Dayi Hu5Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaHeart Center, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaHeart Center, Peking University People’s Hospital, Beijing 100044, ChinaBackground. Prior study showed HCV-infected patients have increased serum N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and a possible left ventricular diastolic dysfunction. The objectives of the present paper were to investigate the characteristics of hs-CRP and its correlation with clinical profiles including NT-proBNP and echocardiographic variables in HCV-infected patients. Methods and Results. A total of 106 HCV-infected patients and 106 control healthy individuals were enrolled. The level of serum hs-CRP (median 1.023 mg/L, range 0.03∼5.379 mg/L) was significantly lower in all 106 patients than that in controls (median 3.147 mg/L, range 0.08~7.36 mg/L, P=0.012). Although hs-CRP did not correlate significantly with NT-proBNP when all patients and controls were included (r=0.169, P=0.121), simple regression analysis demonstrated a statistically significant linear correlation between hs-CRP and NT-proBNP in HCV-infected patients group (r=0.392, P=0.017). Independent correlates of hs-CRP levels (R2=0.13) were older age (β′=0.031, P=0.025) and NT proBNP (β′=0.024, P=0.017). Conclusions. Although the level of serum hs-CRP decreased significantly, there was a significant association between hs-CRP and NT-proBNP in HCV-infected patients.http://dx.doi.org/10.1155/2012/730923 |
| spellingShingle | Wenliang Che Buchun Zhang Wenling Liu Yidong Wei Yawei Xu Dayi Hu Association between High-Sensitivity C-Reactive Protein and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Hepatitis C Virus Infection Mediators of Inflammation |
| title | Association between High-Sensitivity C-Reactive Protein and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Hepatitis C Virus Infection |
| title_full | Association between High-Sensitivity C-Reactive Protein and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Hepatitis C Virus Infection |
| title_fullStr | Association between High-Sensitivity C-Reactive Protein and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Hepatitis C Virus Infection |
| title_full_unstemmed | Association between High-Sensitivity C-Reactive Protein and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Hepatitis C Virus Infection |
| title_short | Association between High-Sensitivity C-Reactive Protein and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Hepatitis C Virus Infection |
| title_sort | association between high sensitivity c reactive protein and n terminal pro b type natriuretic peptide in patients with hepatitis c virus infection |
| url | http://dx.doi.org/10.1155/2012/730923 |
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