Unmasking Hepatitis C Infection: A Case Report of Interstitial Lung Disease as a Potential Extrahepatic Manifestation
Hepatitis C virus (HCV) is the most common blood-borne infection in the United States and is a significant public health concern worldwide. There is a potential association between HCV infection and the development of interstitial lung disease (ILD) as an extrahepatic manifestation. This report deta...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Journal of Advanced Lung Health |
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| Online Access: | https://journals.lww.com/10.4103/jalh.jalh_23_24 |
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| author | Zeina Morcos Chloe Lahoud Waleed Azam Mark Tawfik Yisroel Grabie Sudeep Acharya Thomas Kilkenny |
| author_facet | Zeina Morcos Chloe Lahoud Waleed Azam Mark Tawfik Yisroel Grabie Sudeep Acharya Thomas Kilkenny |
| author_sort | Zeina Morcos |
| collection | DOAJ |
| description | Hepatitis C virus (HCV) is the most common blood-borne infection in the United States and is a significant public health concern worldwide. There is a potential association between HCV infection and the development of interstitial lung disease (ILD) as an extrahepatic manifestation. This report details the case of a 77-year-old female who presented with a chronic productive cough and chest discomfort, initially suspected to be indicative of atypical pneumonia. Despite an initial course of antibiotics, her symptoms persisted, leading to further investigations. Imaging revealed features consistent with ILD prompting additional testing. The patient was noted to have positive results for hepatitis C antibodies and antinuclear antibodies (ANAs), alongside evidence of minimal liver fibrosis. She received 12-week course of antivirals sofosbuvir-velpatasvir for the treatment of hepatitis C infection. Several studies published in the literature have reported a high incidence of HCV infection among patients with ILD. Although definitive clinical and pathological causality remains elusive, the case presented and the literature reviewed strongly suggest a possible role of HCV infection in the onset of ILD. Further research is needed to provide early diagnosis, develop targeted therapeutic strategies, and improve patient outcomes. |
| format | Article |
| id | doaj-art-ca8ee5bdd37643a9b910f7e712fa2e5d |
| institution | Kabale University |
| issn | 2772-7165 2772-7173 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Lung Health |
| spelling | doaj-art-ca8ee5bdd37643a9b910f7e712fa2e5d2025-08-20T03:31:33ZengWolters Kluwer Medknow PublicationsJournal of Advanced Lung Health2772-71652772-71732025-07-015314114410.4103/jalh.jalh_23_24Unmasking Hepatitis C Infection: A Case Report of Interstitial Lung Disease as a Potential Extrahepatic ManifestationZeina MorcosChloe LahoudWaleed AzamMark TawfikYisroel GrabieSudeep AcharyaThomas KilkennyHepatitis C virus (HCV) is the most common blood-borne infection in the United States and is a significant public health concern worldwide. There is a potential association between HCV infection and the development of interstitial lung disease (ILD) as an extrahepatic manifestation. This report details the case of a 77-year-old female who presented with a chronic productive cough and chest discomfort, initially suspected to be indicative of atypical pneumonia. Despite an initial course of antibiotics, her symptoms persisted, leading to further investigations. Imaging revealed features consistent with ILD prompting additional testing. The patient was noted to have positive results for hepatitis C antibodies and antinuclear antibodies (ANAs), alongside evidence of minimal liver fibrosis. She received 12-week course of antivirals sofosbuvir-velpatasvir for the treatment of hepatitis C infection. Several studies published in the literature have reported a high incidence of HCV infection among patients with ILD. Although definitive clinical and pathological causality remains elusive, the case presented and the literature reviewed strongly suggest a possible role of HCV infection in the onset of ILD. Further research is needed to provide early diagnosis, develop targeted therapeutic strategies, and improve patient outcomes.https://journals.lww.com/10.4103/jalh.jalh_23_24extrahepatic manifestationshepatitis c virusidiopathic pulmonary fibrosisinterstitial lung disease |
| spellingShingle | Zeina Morcos Chloe Lahoud Waleed Azam Mark Tawfik Yisroel Grabie Sudeep Acharya Thomas Kilkenny Unmasking Hepatitis C Infection: A Case Report of Interstitial Lung Disease as a Potential Extrahepatic Manifestation Journal of Advanced Lung Health extrahepatic manifestations hepatitis c virus idiopathic pulmonary fibrosis interstitial lung disease |
| title | Unmasking Hepatitis C Infection: A Case Report of Interstitial Lung Disease as a Potential Extrahepatic Manifestation |
| title_full | Unmasking Hepatitis C Infection: A Case Report of Interstitial Lung Disease as a Potential Extrahepatic Manifestation |
| title_fullStr | Unmasking Hepatitis C Infection: A Case Report of Interstitial Lung Disease as a Potential Extrahepatic Manifestation |
| title_full_unstemmed | Unmasking Hepatitis C Infection: A Case Report of Interstitial Lung Disease as a Potential Extrahepatic Manifestation |
| title_short | Unmasking Hepatitis C Infection: A Case Report of Interstitial Lung Disease as a Potential Extrahepatic Manifestation |
| title_sort | unmasking hepatitis c infection a case report of interstitial lung disease as a potential extrahepatic manifestation |
| topic | extrahepatic manifestations hepatitis c virus idiopathic pulmonary fibrosis interstitial lung disease |
| url | https://journals.lww.com/10.4103/jalh.jalh_23_24 |
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