Combination therapy enhances the antiviral activity of IFN-λ against SARS-CoV-2 and MERS-CoV

Combination therapy enhances the antiviral activity of IFN-λ against SARS-CoV-2 and MERS-CoV

Therapeutic options against pathogenic human coronaviruses remain limited. In a recent clinical trial, we demonstrated the therapeutic efficacy of pegylated-IFN-λ in COVID-19 outpatients. However, the emergence of variants that have the potential to evade IFN-mediated antiviral responses raises conc...

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Bibliographic Details
Main Authors: Vahid Rajabali Zadeh, Jocelyne M. Lew, M. Atif Zahoor, Deanna Santer, Jordan J. Feld, Darryl Falzarano
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Virus Research
Subjects:
SARS-CoV-2
MERS-CoV
Interferon lambda
Therapeutics
Variants of concern
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170225000371
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