Selective lysis of acute myeloid leukemia cells by CD34/CD3 bispecific antibody through the activation of γδ T-cells

Selective lysis of acute myeloid leukemia cells by CD34/CD3 bispecific antibody through the activation of γδ T-cells

Despite the considerable progress in acute myeloid leukemia (AML) treatment, relapse after allogeneic hematopoietic stem cell transplantation (HSCT) is still frequent and associated with a poor prognosis. Relapse has been shown to be correlated with an incomplete eradication of CD34+ leukemic stem c...

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Bibliographic Details
Main Authors: Faisal Al Agrafi, Ahmed Gaballa, Paula Hahn, Lucas C. M. Arruda, Adrian C. Jaramillo, Maartje Witsen, Sören Lehmann, Björn Önfelt, Michael Uhlin, Arwen Stikvoort
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Acute myeloid leukemia
bispecific antibodies
cancer immunology
CD34
γδ T-cells
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2379063
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