A Role for Notch Signalling in Breast Cancer and Endocrine Resistance
Over the past decade, there has been growing interest in the Notch signalling pathway within the breast cancer field. This interest stemmed initially from the observation that Notch signalling is aberrantly activated in breast cancer and its effects on various cellular processes including proliferat...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/2498764 |
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| _version_ | 1832562906218102784 |
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| author | Ahmet Acar Bruno M. Simões Robert B. Clarke Keith Brennan |
| author_facet | Ahmet Acar Bruno M. Simões Robert B. Clarke Keith Brennan |
| author_sort | Ahmet Acar |
| collection | DOAJ |
| description | Over the past decade, there has been growing interest in the Notch signalling pathway within the breast cancer field. This interest stemmed initially from the observation that Notch signalling is aberrantly activated in breast cancer and its effects on various cellular processes including proliferation, apoptosis, and cancer stem cell activity. However more recently, elevated Notch signalling has been correlated with therapy resistance in oestrogen receptor-positive breast cancer. As a result, inhibiting Notch signalling with therapeutic agents is being explored as a promising treatment option for breast cancer patients. |
| format | Article |
| id | doaj-art-ca868ed18ad64de1bff407e5efd0a219 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-ca868ed18ad64de1bff407e5efd0a2192025-02-03T01:21:36ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/24987642498764A Role for Notch Signalling in Breast Cancer and Endocrine ResistanceAhmet Acar0Bruno M. Simões1Robert B. Clarke2Keith Brennan3Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UKBreast Biology Group, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UKBreast Biology Group, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UKFaculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UKOver the past decade, there has been growing interest in the Notch signalling pathway within the breast cancer field. This interest stemmed initially from the observation that Notch signalling is aberrantly activated in breast cancer and its effects on various cellular processes including proliferation, apoptosis, and cancer stem cell activity. However more recently, elevated Notch signalling has been correlated with therapy resistance in oestrogen receptor-positive breast cancer. As a result, inhibiting Notch signalling with therapeutic agents is being explored as a promising treatment option for breast cancer patients.http://dx.doi.org/10.1155/2016/2498764 |
| spellingShingle | Ahmet Acar Bruno M. Simões Robert B. Clarke Keith Brennan A Role for Notch Signalling in Breast Cancer and Endocrine Resistance Stem Cells International |
| title | A Role for Notch Signalling in Breast Cancer and Endocrine Resistance |
| title_full | A Role for Notch Signalling in Breast Cancer and Endocrine Resistance |
| title_fullStr | A Role for Notch Signalling in Breast Cancer and Endocrine Resistance |
| title_full_unstemmed | A Role for Notch Signalling in Breast Cancer and Endocrine Resistance |
| title_short | A Role for Notch Signalling in Breast Cancer and Endocrine Resistance |
| title_sort | role for notch signalling in breast cancer and endocrine resistance |
| url | http://dx.doi.org/10.1155/2016/2498764 |
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