The double-edged sword of statins in intracerebral hemorrhage patients: a systematic review and meta-analysis
BackgroundThis meta-analysis aimed to investigate the effect of statins on the prognosis of patients with intracerebral hemorrhage (ICH).MethodsWe conducted a systematic search using the keywords “statin” and “intracerebral hemorrhage” across four electronic databases (PubMed, Cochrane Library, Web...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1519818/full |
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| author | Zheng Li Wen-qi Xu Jiao-qi Wang Jia-hui Yang Xiao-hua Shi Cheng-bing Wang Zhong-xin Xu Jin-lan Jiang |
| author_facet | Zheng Li Wen-qi Xu Jiao-qi Wang Jia-hui Yang Xiao-hua Shi Cheng-bing Wang Zhong-xin Xu Jin-lan Jiang |
| author_sort | Zheng Li |
| collection | DOAJ |
| description | BackgroundThis meta-analysis aimed to investigate the effect of statins on the prognosis of patients with intracerebral hemorrhage (ICH).MethodsWe conducted a systematic search using the keywords “statin” and “intracerebral hemorrhage” across four electronic databases (PubMed, Cochrane Library, Web of Science, and Embase) from their inception to October 31, 2023, to identify studies comparing the effects of statins on the prognosis of patients with ICH. The primary outcome was total mortality after ICH. This meta-analysis was registered online (PROSPERO ID: CRD42023493063).ResultsOur initial search identified 5,543 studies. After applying inclusion criteria, 30 studies with a total of 42,298 patients were included in the final analysis. Our meta-analysis showed that statins significantly reduced overall mortality in patients with ICH (OR: 0.61; 95% CI: 0.51–0.73; I2 = 87%; p < 0.01). Subgroup analyses further demonstrated lower mortality in ICH patients treated with statins compared to those not treated, including in the propensity score matching (PSM) group (OR: 0.59; 95% CI: 0.48–0.74; I2 = 90%; p < 0.01), the prospective cohort study (PCS) group (OR: 0.56; 95% CI: 0.40–0.77; I2 = 89%, p < 0.01), and the retrospective cohort study (RCS) group (OR: 0.64; 95% CI: 0.51–0.81; I2 = 87%, p < 0.01).ConclusionOur meta-analysis of 30 studies suggests that statin use may be associated with improved mortality and functional outcomes in patients with intracerebral hemorrhage (ICH).Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, CRD42023493063. |
| format | Article |
| id | doaj-art-ca82fe3a33824a2bacb0357d40cf6453 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-ca82fe3a33824a2bacb0357d40cf64532025-01-27T15:06:30ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011610.3389/fneur.2025.15198181519818The double-edged sword of statins in intracerebral hemorrhage patients: a systematic review and meta-analysisZheng Li0Wen-qi Xu1Jiao-qi Wang2Jia-hui Yang3Xiao-hua Shi4Cheng-bing Wang5Zhong-xin Xu6Jin-lan Jiang7Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, China-Japan Union Hospital of Jilin University, Changchun, ChinaScientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, ChinaBackgroundThis meta-analysis aimed to investigate the effect of statins on the prognosis of patients with intracerebral hemorrhage (ICH).MethodsWe conducted a systematic search using the keywords “statin” and “intracerebral hemorrhage” across four electronic databases (PubMed, Cochrane Library, Web of Science, and Embase) from their inception to October 31, 2023, to identify studies comparing the effects of statins on the prognosis of patients with ICH. The primary outcome was total mortality after ICH. This meta-analysis was registered online (PROSPERO ID: CRD42023493063).ResultsOur initial search identified 5,543 studies. After applying inclusion criteria, 30 studies with a total of 42,298 patients were included in the final analysis. Our meta-analysis showed that statins significantly reduced overall mortality in patients with ICH (OR: 0.61; 95% CI: 0.51–0.73; I2 = 87%; p < 0.01). Subgroup analyses further demonstrated lower mortality in ICH patients treated with statins compared to those not treated, including in the propensity score matching (PSM) group (OR: 0.59; 95% CI: 0.48–0.74; I2 = 90%; p < 0.01), the prospective cohort study (PCS) group (OR: 0.56; 95% CI: 0.40–0.77; I2 = 89%, p < 0.01), and the retrospective cohort study (RCS) group (OR: 0.64; 95% CI: 0.51–0.81; I2 = 87%, p < 0.01).ConclusionOur meta-analysis of 30 studies suggests that statin use may be associated with improved mortality and functional outcomes in patients with intracerebral hemorrhage (ICH).Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, CRD42023493063.https://www.frontiersin.org/articles/10.3389/fneur.2025.1519818/fullstatinintracerebral hemorrhagemortalitymeta-analysisfunctional prognosis |
| spellingShingle | Zheng Li Wen-qi Xu Jiao-qi Wang Jia-hui Yang Xiao-hua Shi Cheng-bing Wang Zhong-xin Xu Jin-lan Jiang The double-edged sword of statins in intracerebral hemorrhage patients: a systematic review and meta-analysis Frontiers in Neurology statin intracerebral hemorrhage mortality meta-analysis functional prognosis |
| title | The double-edged sword of statins in intracerebral hemorrhage patients: a systematic review and meta-analysis |
| title_full | The double-edged sword of statins in intracerebral hemorrhage patients: a systematic review and meta-analysis |
| title_fullStr | The double-edged sword of statins in intracerebral hemorrhage patients: a systematic review and meta-analysis |
| title_full_unstemmed | The double-edged sword of statins in intracerebral hemorrhage patients: a systematic review and meta-analysis |
| title_short | The double-edged sword of statins in intracerebral hemorrhage patients: a systematic review and meta-analysis |
| title_sort | double edged sword of statins in intracerebral hemorrhage patients a systematic review and meta analysis |
| topic | statin intracerebral hemorrhage mortality meta-analysis functional prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1519818/full |
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