Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats
Objective. To investigate the effects of static magnetic field (SMF) on cutaneous wound healing of Streptozotocin- (STZ-) induced diabetic rats. Methods. 20 STZ-induced diabetic rats were randomly divided into two groups (10 in each group): diabetic rats with SMF exposure group which were exposed to...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/6305370 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849682813057499136 |
|---|---|
| author | Jing Zhao Yong-guo Li Kai-qin Deng Peng Yun Ting Gong |
| author_facet | Jing Zhao Yong-guo Li Kai-qin Deng Peng Yun Ting Gong |
| author_sort | Jing Zhao |
| collection | DOAJ |
| description | Objective. To investigate the effects of static magnetic field (SMF) on cutaneous wound healing of Streptozotocin- (STZ-) induced diabetic rats. Methods. 20 STZ-induced diabetic rats were randomly divided into two groups (10 in each group): diabetic rats with SMF exposure group which were exposed to SMF by gluing one magnetic disk of 230 mT intensity and diabetic rats with sham SMF exposure group (sham group). 10 normal Wistar rats were used as the control group. One open circular wound with 2 cm diameter in the dorsum was generated on both normal and diabetic rats and then covered with sterile gauzes. Wound healing was evaluated by wound area reduction rate, mean time to wound closure, and wound tensile strength. Results. The wound area reduction rate in diabetic rats in comparison with the control group was significantly decreased (P<0.01). Compared with sham magnet group, diabetic rats under 230 mT SMF exposure demonstrated significantly accelerated wound area reduction rate on postoperative days 7, 14, and 21 and decreased gross time to wound closure (P<0.05), as well as dramatically higher wound tissue strength (P<0.05) on 21st day. Conclusion. 230 mT SMF promoted the healing of skin wound in diabetic rats and may provide a non-invasive therapeutic tool for impaired wound healing of diabetic patients. |
| format | Article |
| id | doaj-art-ca7e0cc153fb49fd8a8b378782de7d54 |
| institution | DOAJ |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ca7e0cc153fb49fd8a8b378782de7d542025-08-20T03:24:04ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/63053706305370Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic RatsJing Zhao0Yong-guo Li1Kai-qin Deng2Peng Yun3Ting Gong4Central Laboratory, Medical School of Yangtze University, Hubei 434003, ChinaDepartment of Endocrinology, Central Hospital of Jingzhou City, Hubei 434001, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Yangtze University, Hubei 434000, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Yangtze University, Hubei 434000, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Yangtze University, Hubei 434000, ChinaObjective. To investigate the effects of static magnetic field (SMF) on cutaneous wound healing of Streptozotocin- (STZ-) induced diabetic rats. Methods. 20 STZ-induced diabetic rats were randomly divided into two groups (10 in each group): diabetic rats with SMF exposure group which were exposed to SMF by gluing one magnetic disk of 230 mT intensity and diabetic rats with sham SMF exposure group (sham group). 10 normal Wistar rats were used as the control group. One open circular wound with 2 cm diameter in the dorsum was generated on both normal and diabetic rats and then covered with sterile gauzes. Wound healing was evaluated by wound area reduction rate, mean time to wound closure, and wound tensile strength. Results. The wound area reduction rate in diabetic rats in comparison with the control group was significantly decreased (P<0.01). Compared with sham magnet group, diabetic rats under 230 mT SMF exposure demonstrated significantly accelerated wound area reduction rate on postoperative days 7, 14, and 21 and decreased gross time to wound closure (P<0.05), as well as dramatically higher wound tissue strength (P<0.05) on 21st day. Conclusion. 230 mT SMF promoted the healing of skin wound in diabetic rats and may provide a non-invasive therapeutic tool for impaired wound healing of diabetic patients.http://dx.doi.org/10.1155/2017/6305370 |
| spellingShingle | Jing Zhao Yong-guo Li Kai-qin Deng Peng Yun Ting Gong Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats Journal of Diabetes Research |
| title | Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats |
| title_full | Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats |
| title_fullStr | Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats |
| title_full_unstemmed | Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats |
| title_short | Therapeutic Effects of Static Magnetic Field on Wound Healing in Diabetic Rats |
| title_sort | therapeutic effects of static magnetic field on wound healing in diabetic rats |
| url | http://dx.doi.org/10.1155/2017/6305370 |
| work_keys_str_mv | AT jingzhao therapeuticeffectsofstaticmagneticfieldonwoundhealingindiabeticrats AT yongguoli therapeuticeffectsofstaticmagneticfieldonwoundhealingindiabeticrats AT kaiqindeng therapeuticeffectsofstaticmagneticfieldonwoundhealingindiabeticrats AT pengyun therapeuticeffectsofstaticmagneticfieldonwoundhealingindiabeticrats AT tinggong therapeuticeffectsofstaticmagneticfieldonwoundhealingindiabeticrats |